Complex translocation (7;22) identified in an epithelioid hemangioendothelioma

A Case of Vanishing Metastatic Mass: Right Atrial Mass in the Setting of Primary Epithelioid Hemangioendothelioma of the Spine

“…An in vivo murine model reported that monocyte chemoattractant protein-1 (MCP-1) is required for the proliferation of endothelial cells by stimulating angiogenic behavior with anti-MCP-1 therapy leading to failure of tumor development [3]. Boudousquie et al [4] reported several complex clonal abnormalities, an unbalanced translocation of chromosome 7 and 22 having multiple breakpoints, a robertsonian translocation of chromosome 14, and loss of chromosome Y that could be involved in the pathogenesis. Errani et al [5] concentrated on recurrent translocation t(1; 3)(p36.23;q25.1) involving calmodulin-binding transcription activator 1 (CAMTA1) on chromosome 1p36.23 and WW domain-containing transcription activator 1 (WWTR1) on chromosome 3q25.1.…”

Hemangioendotelioma epitelioide pulmonar: Reporte de un caso

“…La distribución según género es de 1:4 mayor en mujeres [5][6][7] . Su etiología está aún en estudio, se asocia a moduladores de la angiogénesis y a la Proteína de Quimiotaxis de Monocitos 1, que serían necesarios para la proliferación tumoral, a su vez, Budousquie et al describieron gran variedad de alteraciones clonales destacando translocación 7 y 22, translocaciones robertsonianas del cromosoma 14 y la pérdida del cromosoma Y [8][9][10] . Actualmente se ha relacionado la infección por Bartonella (B. henselae, B. quintana, B. bacilliformis) al desarrollo de este tumor.…”

Pulmonary epithelioid hemangioendothelioma: Report of three cases

“…15 An identical translocation involving chromosomes 1 and 3 [t(1;3)(p36.3q25)] has been reported in soft tissue PEH, thus possibly representing a characteristic rearrangement for this entity. 16,17 As most patients have asymptomatic symptoms, such as cough, dyspnea, or chest pain, the diagnosis of PEH can often be diffi cult for the clinician. The roentgenological fi ndings, such as multiple bilateral nodules, often suggest other diseases.…”