Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction

Aspirin Resistance: Current Status and Role of Tailored Therapy

“…The rate of aspirin noncompliance is difficult to measure in clinical trials. Schwartz et al 25 followed 190 patients after an MI who were thought to be taking daily aspirin and found that 9% had a noninhibited aggregation response by light aggregometry. In these same patients, platelets were inhibited in all but 1 patient 2 hours after observed aspirin ingestion, suggesting that they were aspirin noncompliant.…”

“…In these same patients, platelets were inhibited in all but 1 patient 2 hours after observed aspirin ingestion, suggesting that they were aspirin noncompliant. 25 Von Pape et al 26 found that in 212 patients with a history of MI, 18.4% had a suboptimal antiplatelet response as measured using PFA-100. These patients underwent counseling and reinforcement and 1 week later, only 10.4% of patients had a suboptimal antiplatelet response.…”

Relationship between Vitamin D Binding Protein and Aspirin Resistance in Coronary Ischemic Patients: A Proteomic Study

“…Indeed, up to 40% of patients with cardiovascular disease do not comply with aspirin therapy. 41 In this regard, we administered an additional aspirin dose to confirm the result of the PFA-100 assay, and we only included in the study patients that demonstrated a similar CT range in response to epinephrine at inclusion and 1 h after the additional 100 mg aspirin administration.…”

Sex is fun, remember?

“…In one study only one of the 17 patients who had been judged to be aspirin resistant failed to show the expected platelet response to aspirin when aspirin was taken under close supervision. 2 Paradoxically, although platelet aggregation showed a large range in men in a large cohort, there was no evidence that the degree of platelet aggregation is predictive of subsequent heart disease events. 34 The authors' estimate of the beneficial effect of aspirin in sensitive patients is remarkably close to the 51% reduction reported for the doctors in the US physicians health study who claimed that they had taken aspirin regularly, compared with a 17% reduction in those who admitted that they had taken the drug on less than half the days.…”

“…1 Spain, together with Greece, stands out as the European country with the highest levels of condom use among young people, with 90% of sexually active young people reporting using a condom the last time they had sexual intercourse. 2 Nevertheless, the rates of sexually transmitted infections (STIs) are increasing year after year, despite more than a decade of intensive official educational campaigns transmitting the message to young people that condoms and only condoms are the magic bullets to prevent all STIs and unintended pregnancies. 3 There is no room for dissent, no consideration for the accrual of persuasive scientific evidence strongly supporting that other behaviour changes, such as partner reduction, should be promoted as a priority.…”