Compliance to Screening Protocols for Multidrug-Resistant Microorganisms at the Emergency Departments of Two Academic Hospitals in the Dutch–German Cross-Border Region

Gunnink, Lisa B; Arouri, D J; Jolink, Floris E J; Lokate, Mariëtte; Jonge, K. De; Kampmeier, Stefanie; Kreis, Carolin; Raschke, Michael J.; Kleinjan, Mirjam; Maaten, Jan C. ter; Friedrich, Alex; Bathoorn, Erik; Glasner, Corinna

doi:10.3390/tropicalmed6010015

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…The inherent differences in healthcare structures could serve as a primary explanation for this difference [ 25 , 28 ]. Both Germany and the Netherlands have well-established healthcare systems, however, they differ in important aspects [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the differences in healthcare structure, there are also variations in the national German and Dutch IPC guidelines for the prevention of VRE in hospitals [ 25 ]. The frequency of MDROs in hospitals could serve as an indicator of the effectiveness of IPC measures.…”

Section: Discussionmentioning

confidence: 99%

“…Although Germany and the Netherlands have many common historical, cultural, and social values, they differ in many aspects regarding healthcare. These differences include amongst others the healthcare structure, antibiotic prescription habits, and local and national infection prevention and control (IPC) guidelines for multidrug-resistant microorganisms (MDRO) [ 25 – 27 ]. All these aspects taken together may be the cause for the differences in VRE rates encountered in these two neighboring countries [ 25 , 27 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Vancomycin-resistant enterococci (VRE) in hospital settings across European borders: a scoping review comparing the epidemiology in the Netherlands and Germany

Cimen

Berends

Bathoorn

et al. 2023

Antimicrob Resist Infect Control

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The rising prevalence of vancomycin-resistant enterococci (VRE) is a matter of concern in hospital settings across Europe without a distinct geographical pattern. In this scoping review, we compared the epidemiology of vancomycin-resistant Enterococcus spp. in hospitals in the Netherlands and Germany, between 1991 and 2022. We searched PubMed and summarized the national antibiotic resistance surveillance data of the two countries. We included 46 studies and summarized national surveillance data from the NethMap in the Netherlands, the National Antimicrobial Resistance Surveillance database in Germany, and the EARS-Net data. In total, 12 studies were conducted in hospitals in the Netherlands, 32 were conducted in German hospitals, and an additional two studies were conducted in a cross-border setting. The most significant difference between the two countries was that studies in Germany showed an increasing trend in the prevalence of VRE in hospitals, and no such trend was observed in studies in the Netherlands. Furthermore, in both Dutch and German hospitals, it has been revealed that the molecular epidemiology of VREfm has shifted from a predominance of vanA towards vanB over the years. According to national surveillance reports, vancomycin resistance in Enterococcus faecium clinical isolates fluctuates below 1% in Dutch hospitals, whereas it follows an increasing trend in German hospitals (above 20%), as supported by individual studies. This review demonstrates that VRE is more frequently encountered in German than in Dutch hospitals and discusses the underlying factors for the difference in VRE occurrence in these two neighboring countries by comparing differences in healthcare systems, infection prevention control (IPC) guidelines, and antibiotic use in the Netherlands and Germany.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vancomycin-resistant enterococci (VRE) in hospital settings across European borders: a scoping review comparing the epidemiology in the Netherlands and Germany

Cimen

Berends

Bathoorn

et al. 2023

Antimicrob Resist Infect Control

Self Cite

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“…After evaluating its use in 1507 patients between 2016 and 2018, several issues were spotted regarding scaling of the screening process and treatment initiation. In a study by Gunnink et al, the national screening protocols for multidrug-resistant microorganisms, as well as local screening protocols between two hospitals on the Dutch-German border, were compared [ 3 ]. Practicality of the screening protocols was sufficient, but the comparison detected several issues that may impair consistency between different protocols and complicate patient care.…”

Section: Diagnostics and Screeningmentioning

confidence: 99%

Infection Prevention and Control: Practical and Educational Advances

Tsioutis

Karageorgos

2022

TropicalMed

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Rapid in vitro differentiation of bacteria by ion mobility spectrometry

Steppert

Schönfelder

Schultz

et al. 2021

Appl Microbiol Biotechnol

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Rapid screening of infected people plays a crucial role in interrupting infection chains. However, the current methods for identification of bacteria are very tedious and labor intense. Fast on-site screening for pathogens based on volatile organic compounds (VOCs) by ion mobility spectrometry (IMS) could help to differentiate between healthy and potentially infected subjects. As a first step towards this, the feasibility of differentiating between seven different bacteria including resistant strains was assessed using IMS coupled to multicapillary columns (MCC-IMS). The headspace above bacterial cultures was directly drawn and analyzed by MCC-IMS after 90 min of incubation. A cluster analysis software and statistical methods were applied to select discriminative VOC clusters. As a result, 63 VOC clusters were identified, enabling the differentiation between all investigated bacterial strains using canonical discriminant analysis. These 63 clusters were reduced to 7 discriminative VOC clusters by constructing a hierarchical classification tree. Using this tree, all bacteria including resistant strains could be classified with an AUC of 1.0 by receiver-operating characteristic analysis. In conclusion, MCC-IMS is able to differentiate the tested bacterial species, even the non-resistant and their corresponding resistant strains, based on VOC patterns after 90 min of cultivation. Although this result is very promising, in vivo studies need to be performed to investigate if this technology is able to also classify clinical samples. With a short analysis time of 5 min, MCC-IMS is quite attractive for a rapid screening for possible infections in various locations from hospitals to airports.Key Points• Differentiation of bacteria by MCC-IMS is shown after 90-min cultivation.• Non-resistant and resistant strains can be distinguished.• Classification of bacteria is possible based on metabolic features.

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Compliance to Screening Protocols for Multidrug-Resistant Microorganisms at the Emergency Departments of Two Academic Hospitals in the Dutch–German Cross-Border Region

Cited by 3 publications

References 41 publications

Vancomycin-resistant enterococci (VRE) in hospital settings across European borders: a scoping review comparing the epidemiology in the Netherlands and Germany

Vancomycin-resistant enterococci (VRE) in hospital settings across European borders: a scoping review comparing the epidemiology in the Netherlands and Germany

Infection Prevention and Control: Practical and Educational Advances

Rapid in vitro differentiation of bacteria by ion mobility spectrometry

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