Complicated genotypes circulating among treatment naïve HIV-1 patients in Guangzhou, China

Lan, Yun; He, Xiang; Li, Linghua; Zhou, Pingping; Huang, Xuhe; Deng, Xizi; Li, Junbin; Fan, Qinghong; Li, Feng; Tang, Xiaoping; Cai, Weiping; Hu, Fengyu

doi:10.1016/j.meegid.2020.104673

Cited by 15 publications

(13 citation statements)

References 40 publications

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“…17,18 In the present study, CRF55_01B was the third most dominant circulating genotype, accounting for 21.4%, higher than the 8.5% in Guangdong in 2013, 19 9.2% in Shenzhen in 2006-2013, 18 and 10.7% in Guangzhou in 2018. 20 The overall prevalence of drug resistance was 66.7% in MSM with ART failure in Guangdong, which was similar to that in Yunnan (66.27% in MSM with ART failure from 2014 to 2019) 21 and relatively higher than those in other areas of China, such as Sichuan (50.7% in MSM with ART failure from 2011 to 2017) 22 and Hunan (41.3% in MSM with ART failure from 2012 to 2017). 23 M184I/V (42.2%) was the most prevalent NRTIassociated mutation, which might be caused by the frequent use of 3TC in ART-experienced patients.…”

Section: Discussionmentioning

confidence: 55%

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HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014–2019

Lan¹,

Deng²,

Li³

et al. 2021

IDR

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Background Guangdong, located in South China, is one of the areas heavily affected by HIV-1 in China. The transmission of HIV-1 among men who have sex with men (MSM) has gradually been increasing in Guangdong. Objective To investigate the characteristics of the HIV-1 drug resistance, and genetic transmission networks in MSM with antiretroviral therapy (ART) failure from 2014 to 2019 in Guangdong. Methods HIV-1 pol gene sequences were amplified. An online subtyping tool was used to determine the genotype, and a maximum likelihood phylogenetic tree was reconstructed to confirm the genotype results. The Stanford University HIV Drug Resistance Database was used to analyse the sequences of drug resistance mutations (DRMs) and drug resistance profiles. A pairwise Tamura-Nei 93 genetic distance-based method was used to analyse the genetic transmission networks. Results Of 393 sequences isolated from HIV-infected MSM with ART failure, CRF01_AE (47.3%), CRF07_BC (21.4%) and CRF55_01B (21.4%) were the top three strains. 55.2% individuals harboured NRTI DRMs, whereas 67.4% carried NNRTI DRMs. 96.8% cases harboured mutations resistance to NRTIs or NNRTIs at high-level. The most common DRMs were M184I/V (42.2%), followed by V179D/E (37.9%) and K65R (27.2%). Of the subtype B sequences, no sequence fell into a cluster. Of the CRF01_AE, CRF55_01B, and CRF59_01B sequences, 14.5%, 61.9%, and 33.3% fell into clusters, respectively. Of the CRF07_BC sequences, 39.3% fell into clusters. The majority of MSM in transmission networks were concentrated at age below 35 years old, with multiple links. Moreover, approximately 54.8% of MSM had more than 2 potential transmission partners. Conclusion Drug resistance mutations more frequently occurred in NNRTIs among MSM with ART failure in Guangdong Province. Transmission network analysis revealed a complex transmission pattern, and more attention should be given to younger HIV-1-infected MSM with multiple links.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014–2019

Lan¹,

Deng²,

Li³

et al. 2021

IDR

Self Cite

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“…The results have discovered similar proportions in the genotypes of the EHI case compared to those in other cities in the same province. For example, the first dominant HIV-1 subtype circulating among MSM in Guangzhou was CRF07_BC (41.6%), followed by CRF01_AE (30.0%), and the same was found in Shenzhen, with CRF07_BC (39.1%) and CRF01_AE (35.1%) being the most predominant (42,43). HIV-1 subtypes are associated with the pathogenesis and progression of AIDSdefining illness in the infected host (44).…”

Section: Discussionmentioning

confidence: 99%

Comparison between HIV self-testing and facility-based HIV testing approach on HIV early detection among men who have sex with men: A cross-sectional study

et al. 2022

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BackgroundTo assess whether HIV self-testing (HIVST) has a better performance in identifying HIV-infected cases than the facility-based HIV testing (HIVFBT) approach.MethodsA cross-sectional study was conducted among men who have sex with men (MSM) by using an online questionnaire (including information on sociodemographic, sexual biography, and HIV testing history) and blood samples (for limiting antigen avidity enzyme immunoassay, gene subtype testing, and taking confirmed HIV test). MSM who were firstly identified as HIV positive through HIVST and HIVFBT were compared. Chi-square or Fisher’s exact test was used to explore any association between both groups and their subgroups.ResultsIn total, 124 MSM HIV cases were identified from 2017 to 2021 in Zhuhai, China, including 60 identified through HIVST and 64 through HIVFBT. Participants in the HIVST group were younger (≤30 years, 76.7% vs. 46.9%), were better educated (>high school, 61.7% vs. 39.1%), and had higher viral load (≥1,000 copies/ml, 71.7% vs. 50.0%) than MSM cases identified through HIVFBT. The proportion of early HIV infection in the HIVST group was higher than in the HIVFBT group, identified using four recent infection testing algorithms (RITAs) (RITA 1, 46.7% vs. 25.0%; RITA 2, 43.3% vs. 20.3%; RITA 3, 30.0% vs. 14.1%; RITA 4, 26.7% vs. 10.9%; all p < 0.05).ConclusionsThe study showed that HIVST has better HIV early detection among MSM and that recent HIV infection cases mainly occur in younger and better-educated MSM. Compared with HIVFBT, HIVST is more accessible to the most at-risk population on time and tends to identify the case early. Further implementation studies are needed to fill the knowledge gap on this medical service model among MSM and other target populations.

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“…22 In addition, a cross-sectional survey of newly diagnosed HIV-infected individuals in Guangdong Province in 2018 showed that CRF07_BC infections were an important factor associated with transmission. 23 CRF07_BC was the most dominant strain in both Guangzhou 24 and Shenzhen 25 and constituted the largest transmission network in these regions.…”

Section: Understanding Of Transmission Trends Of Main Hiv Subtypes/re...mentioning

confidence: 99%

Practice and Prospect: HIV-1 Molecular Network-Based Studies in China

Qiu

Zhao

Han

et al. 2022

Infectious Microbes and Diseases

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Identification of human immunodeficiency virus (HIV) transmission networks is a critical step in the public health response; however, it is challenging to achieve this through traditional epidemiological surveys alone. The molecular network approach can provide more accurate information for understanding HIV outbreaks and bring targeted interventions into reality. Based on the current global development of the concept of the molecular network, Chinese scientists have in recent years explored the applications of molecular networks for understanding the HIV-1 transmission trends, for identifying the population acquiring priority interventions, and for evaluating the targeted intervention effectiveness. In this review, we focus on research progress by Chinese scientists in the field of molecular networks and put forward some suggestions for future research of molecular networks.

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Complicated genotypes circulating among treatment naïve HIV-1 patients in Guangzhou, China

Cited by 15 publications

References 40 publications

HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014–2019

HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014–2019

Comparison between HIV self-testing and facility-based HIV testing approach on HIV early detection among men who have sex with men: A cross-sectional study

Practice and Prospect: HIV-1 Molecular Network-Based Studies in China

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