Complication in diabetic nephropathy

John, Sharon

doi:10.1016/j.dsx.2016.06.005

Cited by 56 publications

(40 citation statements)

References 1 publication

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“…This could be due to the complexity of aetiological factors associated with diabetic nephropathy. The prevention and treatment of diabetic nephropathy requires a multiple risk factor approach, the goal being to achieve glycaemic control along with reduction of hypertension and dyslipidaemia [31]. This medical need is, as yet, unmet.…”

Section: Discussionmentioning

confidence: 99%

A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

et al. 2018

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Section: Discussionmentioning

confidence: 99%

A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

et al. 2018

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“…Nefropati diabetika dapat dicegah dengan mengelola faktor-faktor risikonya serta terapi yang sesuai. 15 Penelitianpenelitian sebelumnya menunjukkan bahwa faktor risiko nefropati diabetika antara lain lama menderita diabetes ≥15 tahun, usia ≥45 tahun, retinopati, neuropati, etnik/ras, faktor genetik, riwayat keluarga dengan penyakit kardiovaskuler, hipertensi, hiperlipidemia, jenis kelamin laki-laki, kebiasaan merokok, pengendalian glikemik yang tidak baik, 16 aktifitas fisik, hiperurisemia, 10,17 dan kebiasaan merokok. 18 Penelitian lain menyebutkan bahwa faktor risiko utama nefropati diabetika yaitu kolesterol plasma yang tinggi, ratarata tekanan darah yang tinggi serta pengendalian glikemik yang tidak baik.…”

Section: Pendahuluanunclassified

Faktor Risiko Kejadian Nefropati Diabetika pada Wanita

Wahyuningsih¹,

Nugroho

Suhartono

et al. 2019

Comm. Health. Epid. J

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Background : Diabetic nephropathy was the most frequent complication in diabetics. The prevalence in women at South East Asia country was higher than men, that different than in Europe, American and African. It's be controversial thing. There was no reseacrh about the risk factors for diabetic nephropathy in women in Indonesia. Methods : The purpose of this study was to determine the risk factors for stage 3-5 diabetic nephropathy in women. This research usesd case control study design. The cases were women with stage 3-5 diabetic nephropathy. Sampling by consecutive sampling technique by comparing the age of the case. Data were analyzed statistically by univariate, bivariate and multivariate using multiple logistic regression analysis. Results : The results of the analysis showed that the risk factors for stage 3-5 diabetic nephropathy were hyperuricemia (OR:9.6; 95%CI:1.870-45.799), lack of physical activity (OR:9.5; 95%CI:1.693-53,287), blood sugar level ≥126 mg/dl (OR:14.7; 95% CI:1.487-145.846), history of oral contraceptive use (OR:7.3; 95%CI:1.254-42.716) and history of obesity (OR:8.9;. Conclusion : It is recommended for diabetics people to control uric acid levels, fasting blood glucose, body weight and do enough physical activity. For oral contraceptives users it is recommended to consult with a doctor during consumption.

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“…Diabetic nephropathy (DN), one of the most serious microvascular complications of diabetes mellitus, is the leading cause of end-stage renal disease in developed countries and major cause of diabetes-related death (1,2). It is characterized by kidney hypertrophy, glomerulus and tubular basement membrane thickening, tubular interstitial fibrosis and arteriosclerosis (3,4), which is largely due to mesangial cell proliferation, extracellular matrix (ECM) deposition.…”

Section: Introductionmentioning

confidence: 99%

KATP channels in high glucose-induced rat mesangial cell proliferation and release of MMP-2 and fibronectin

Zhang

Shi

Zou

et al. 2017

Experimental and Therapeutic Medicine

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ATP-sensitive potassium (KATP) channels are well characterized in cardiac, pancreatic and many other muscle cells. The purpose of this study was to determine if KATP channels play a role in diabetic nephropathy (DN). In the present study, functional expression of the KATP channel was examined in rat mesangial cells with or without high glucose (HG) stimulation. The mesangial cell proliferation and the release of matrix metalloproteinase (MMP)-2 and fibronectin in response to high glucose with a selective opener of KATP (diazoxide, DZX), or with a selective inhibitor of KATP (5-hydroxydecanoate, 5-HD) were also measured. The cell proliferation was observed using Cell Counting Kit-8 assay, and the mRNA expressions of KATP subunit, including Kir6.1, Kir6.2, sulfonylurea receptor 1 (SUR1), SUR2A and SUR2B, were assessed using quantitative real-time PCR. MMP-2 and fibronectin release was measured by ELISA. The present study clarified expression of SUR subunit of KATP in plasma. HG treatment could cause increased cell proliferation and release of MMP-2 and fibronectin in a dose-dependent manner. HG also significantly decreased the expression of Kir6.1, SUR2A and SUR2B. Pretreatment of DZX markedly decreased the expression of SUR1, SUR2A and SUR2B, but had no effect on Kir6.1 expression compared with HG alone, while these changes were inhibited by 5-HD pretreatment. Moreover, DZX also inhibited cell proliferation and release of MMP-2 and fibronectin in HG-induced rat mesangial cells, and that was corrected by 5-HD. These data suggest that HG stimulates mesangial cell proliferation and cellular matrix release via inhibiting KATP channel activity, leading us to propose that KATP channel dysfunction may be involved in the development of DN.

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Complication in diabetic nephropathy

Cited by 56 publications

References 1 publication

A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes

Faktor Risiko Kejadian Nefropati Diabetika pada Wanita

KATP channels in high glucose-induced rat mesangial cell proliferation and release of MMP-2 and fibronectin

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