Complications after breast cancer surgery in patients treated with concomitant preoperative chemoradiation: a case–control analysis

Abstract

Postoperative wound complications were not different from those observed in non-radiated patients, but its rate was higher. Epidermolysis was associated with SSI and/or flap necrosis. Careful surgical technique should be encouraged.

New treatment sequence protocol to reconstruct locally advanced breast cancer

“…Wound complication rates were 46% (infection 17%, skin flap necrosis 17% or both 12%), similar to other series and 7% suffered late dehiscence after suture removal . While the nature of complications in those receiving neoadjuvant chemoradiotherapy were similar to those receiving no treatment before surgery or chemotherapy alone, their incidence was greater …”

“…Our group suggests that those who would normally be offered neoadjuvant chemotherapy and adjuvant radiotherapy instead have both treatments in the neoadjuvant setting prior to mastectomy at which immediate free autologous reconstruction (TRAM/DIEP) is also performed. Of the few similar trials published with small numbers of patients with LABC treated by neoadjuvant chemotherapy followed by preoperative radiotherapy, none have included free autologous/perforator flap reconstruction as an end point for assessment . We propose a strategy to evaluate this combined cancer management and reconstructive pathway.…”

A Comparative Analysis and Systematic Review of the Wound-Healing Milieu: Implications for Body Contouring after Massive Weight Loss

“…22 Alternatively, wound complication data from some of the largest studies of cancer, burn, transplant, and obese populations are listed in Table 1. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] In an investigation of 360 women with breast carcinoma treated with chemotherapy, radiation, and radical or modified radical mastectomy, 45.8 percent of patients developed wound complications, including infection (16.6 percent), flap necrosis (16.9 percent), or both (12.2 percent). In addition, 25.8 percent experienced epidermolysis, 22.2 percent developed seroma, and 6.9 percent had dehiscence.…”

“…In addition, 25.8 percent experienced epidermolysis, 22.2 percent developed seroma, and 6.9 percent had dehiscence. 11 Although some studies report breast cancer wound complication rates as low as 9 percent, others describe wound infection, flap necrosis, and epidermolysis each occurring in 10.2, 6.1, and 8.9 percent of patients, respectively. 12,13 Similarly, 11 percent of women treated for epithelial ovarian cancer encounter wound complicationsnotably, dehiscence and infection-irrespective of chemotherapeutic interventions.…”

“…Clinical evidence demonstrates that cancer, burn, transplant, and obese populations experience similar rates of wound-healing complications as massive weight loss patients following body contouring, rates exceeding 30 percent. [11][12][13][14][15][16][17][18][19][20][21] Understanding the molecular changes governing aberrant healing for these populations may elucidate the underlying abnormalities causing delayed healing in the massive weight loss wound environment.…”