Complications associated with Plasmodium vivax malaria: A retrospective study from a tertiary care hospital based in western Uttar Pradesh, India

Rizvi, Imran; Tripathi, Devendra Kumar; Chughtai, Anjum Mirza; Beg, M. Salim; Zaman, Shamsuz; Zaidi, Noorin

doi:10.4103/1596-3519.117624

Cited by 33 publications

(31 citation statements)

References 18 publications

(58 reference statements)

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“…Many studies were conducted in India (n = 10) [10], [28], [31], [32], [34], [35], [37], [42], [44], [45], Indonesia (n = 5) [8], [26], [27], [40], [41]. The remaining studies came from Pakistan (n = 3) [30], [43], [46], PNG (n = 3) [29], [38], [39], Brazil (n = 2) [24], [36], Ethiopia (n = 1) [33], Malaysia (n = 1) [25] and Sudan (n = 1) [23].…”

Section: Resultsmentioning

confidence: 99%

Is Plasmodium vivax Malaria a Severe Malaria?: A Systematic Review and Meta-Analysis

et al. 2014

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Background Plasmodium vivax is one of the major species of malaria infecting humans. Although emphasis on P. falciparum is appropriate, the burden of vivax malaria should be given due attention. This study aimed to synthesize the evidence on severe malaria in P. vivax infection compared with that in P. falciparum infection.Methods/Principal FindingsWe searched relevant studies in electronic databases. The main outcomes required for inclusion in the review were mortality, severe malaria (SM) and severe anaemia (SA). The methodological quality of the included studies was assessed using the Newcastle-Ottawa Scale. Overall, 26 studies were included. The main meta-analysis was restricted to the high quality studies. Eight studies (n = 27490) compared the incidence of SM between P. vivax infection and P. falciparum mono-infection; a comparable incidence was found in infants (OR: 0.45, 95% CI:0.04–5.68, I 2:98%), under 5 year age group (OR: 2.06, 95% CI: 0.83–5.1, I 2:83%), the 5–15 year-age group (OR: 0.6, 95% CI: 0.31–1.16, I 2:81%) and adults (OR: 0.83, 95% CI: 0.67–1.03, I 2:25%). Six studies reported the incidences of SA in P. vivax infection and P. falciparum mono-infection; a comparable incidence of SA was found among infants (OR: 3.47, 95%:0.64–18.94, I 2: 92%), the 5–15 year-age group (OR:0.71, 95% CI: 0.06–8.57, I 2:82%). This was significantly lower in adults (OR:0.75, 95% CI: 0.62–0.92, I 2:0%). Five studies (n = 71079) compared the mortality rate between vivax malaria and falciparum malaria. A lower rate of mortality was found in infants with vivax malaria (OR:0.61, 95% CI:0.5–0.76, I 2:0%), while this was comparable in the 5–15 year- age group (OR: 0.43, 95% CI:0.06–2.91, I 2:84%) and the children of unspecified-age group (OR: 0.77, 95% CI:0.59–1.01, I 2:0%).ConclusionOverall, the present analysis identified that the incidence of SM in patients infected with P. vivax was considerable, indicating that P. vivax is a major cause of SM. Awareness of the clinical manifestations of vivax malaria should prompt early detection. Subsequent treatment and monitoring of complications can be life-saving.

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Section: Resultsmentioning

confidence: 99%

Is Plasmodium vivax Malaria a Severe Malaria?: A Systematic Review and Meta-Analysis

et al. 2014

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“…In recent years the morbidity and mortality of P. vivax have been shown to have been underestimated, with evidence of direct fatality and contribution to mortality in patients who have other co-morbidities, such as malnutrition, human immunodeficiency virus (HIV), or co-existing infections (Baird 2013;Bhattacharjee 2013;Rizvi 2013;Battle 2014;Douglas 2014;Kochar 2014;Arévalo-Herrera 2015;Baird 2015b). Repeated P. vivax infections through childhood and adulthood also affect personal well-being, development, and education and can thus negatively impact economic development, both for the individual and the community (Mendis 2001).…”

Section: B a C K G R O U N Dmentioning

confidence: 99%

Primaquine at alternative dosing schedules for preventing relapse in people withPlasmodium vivaxmalaria

Milligan

Daher

Graves

2017

Cochrane Database of Systematic Reviews

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“…36 The majority of the cases have either isolated infection with Plasmodium falciparum 37 or a mixed infection with both P. falciparum and Plasmodium vivax 38 and rarely with P. vivax alone. 39 The incidence of jaundice is reported to be 2.58% only. 40 In a study of the 732 adult patients with falciparum malaria, only 39 (5.3%) were noted to have jaundice and only 18 (2.45%) had evidence of malarial hepatitis.…”

Section: Malarial Hepatopathymentioning

confidence: 99%

Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics

Anand

Garg

2015

Journal of Clinical and Experimental Hepatology

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Complications associated with Plasmodium vivax malaria: A retrospective study from a tertiary care hospital based in western Uttar Pradesh, India

Abstract: P. vivax has immense potential to cause life threatening complications and even death, more research is required to understand the exact pathogenesis of various complications encountered in vivax malaria.

Cited by 33 publications

References 18 publications

Is Plasmodium vivax Malaria a Severe Malaria?: A Systematic Review and Meta-Analysis

Is Plasmodium vivax Malaria a Severe Malaria?: A Systematic Review and Meta-Analysis

Primaquine at alternative dosing schedules for preventing relapse in people withPlasmodium vivaxmalaria

Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics

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