Background: Today, the solutions for skin aging and rejuvenation methods are of special importance. Objectives: This study aims to investigate the desire to perform various methods related to facial rejuvenation in Iran and the world. Methods: It is an ecological study conducted using the Google Trends (GT) database. We initially searched for users' specified search terms related to "Botox," "Gel injection," "Laser," "Facelift," "Fillers," and "COVID-19" among all searches performed using GTs in the world and Iran from January 2017 to July 2023. Results: The trend of GT shows that the search volume for laser and filler services is higher than for other services worldwide. In Iran, laser and gel injections had the highest search volume until 2022. However, from 2022 onwards, fillers have become one of the top searched services. In 2020, with the onset of the COVID-19 pandemic, the significant impact of the pandemic on facial rejuvenation procedures worldwide, including in Iran, became evident. There is a significant negative correlation between the volume of searches for COVID-19 and facial rejuvenation procedures worldwide (R2 = -0.52, P = 0.0001) and in Iran (R2 = -0.84, P = 0.0001). Conclusions: Many people worldwide and in Iran are looking for facial rejuvenation. Clinicians can enter this business with a positive outlook. GT data is a powerful tool for predicting the demand for facial rejuvenation procedures.