Components ofHaplophyllum bucharicum

Nesmelova, E. F.; Bessonova, I. A.; Yunusov, S. Yu.

doi:10.1007/bf00579670

Cited by 4 publications

(6 citation statements)

References 2 publications

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“…EIMS established that 1 and 2 had the same molecular formula, C 19 H 23 NO 2 . Their 1 H-NMR, 13 C-NMR, IR, UV, and MS spectral data corresponded closely with those reported for the known compounds buchapine ( 1 ) and 3-(3-methyl-2-butenyl)-4-[(3-methyl-2-butenyl)oxy]-2(1 H )-quinolinone ( 2 ), both originally isolated from Haplophylum tuberculatum . Buchapine ( 1 ) did not exhibit optical activity, consistent with the literature …”

Section: Resultssupporting

confidence: 79%

“…Buchapine (1) : white solid; HREIMS m/z 297.1728 (calcd for C 19 H 23 NO 2 , 297.1729). IR, UV, 13 C-NMR, and 1 H NMR (CDCl 3 ) data were consistent with the literature …”

Section: Methodssupporting

confidence: 88%

“…3-(3-Methyl-2-butenyl)-4-[(3-methyl-2-butenyl)oxy]-2(1 H )-quinolinone (2) : white solid; HREIMS m/z 297.1735 (calcd for C 19 H 23 NO 2 , 297.1729). All spectral data including IR, UV, 13 C-NMR, and 1 H NMR (CDCl 3 ) correspond closely with literature reports. , …”

Section: Methodssupporting

confidence: 85%

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HIV Inhibitory Natural Products. 26. Quinoline Alkaloids from Euodia roxburghiana

et al. 1996

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Section: Resultssupporting

confidence: 79%

“…Buchapine (1) : white solid; HREIMS m/z 297.1728 (calcd for C 19 H 23 NO 2 , 297.1729). IR, UV, 13 C-NMR, and 1 H NMR (CDCl 3 ) data were consistent with the literature …”

Section: Methodssupporting

confidence: 88%

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HIV Inhibitory Natural Products. 26. Quinoline Alkaloids from Euodia roxburghiana

et al. 1996

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“…Two known quinoline alkaloids, buchapine (58) [81][82] and 3-(3′-methyl-2′-butenyl)-4-[(3′-methyl-2′-butenyl)oxy]-2(1H)-quinolinone (59) [83], and three new furoquinoline alkaloids, roxiamines were extracted from Euodia roxburghiana [84]. The activity against infectious HIV-1 were with an EC 50 value of 0.94µM and an IC 50 value of 29.0µM for 58, and with an EC 50 value of 1.64µM and an IC 50 value of 26.9µM for 59 and the activity in HIV-1 RT were with an IC 50 value of 12µM for 58 and an IC 50 value of 8 µM for 59 [84].…”

Section: Terpenesmentioning

confidence: 99%

Recent Studies on Natural Products as Anti-HIV Agents

Jung¹,

Lee²,

Kim³

et al. 2000

CMC

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The discovery of medicinal agents capable of specifically inhibiting human immunodeficiency virus (HIV) is urgently needed due to its globally widespread infection. Most of clinically useful anti-HIV agents are nucleosides but their use is limited due to their severe toxicity and emerging drug resistance. More than 50% of world marketed drugs have their origin of the nature. Natural products, of which structural diversity is so broad, are good sources for the effective discovery of anti-HIV agents with decreased toxicity. Over the past decade, substantial progress has been made in research on the natural products for the anti-HIV agents. New natural products that have potent anti-HIV activities with novel structures were reviewed in this article. These compounds, isolated mainly from medicinal plants, in this review have been classified as secondary metabolites such as terpenes, phenolics, and naturally scarce peptides and sugars. Especially, terpenes and phenol substances have gained much interest due to their significant anti-HIV activities along with their structural diversity. Recent studies also showed that several polysaccharides are effective inhibitors of HIV replication. Most of chemotherapeutic targets reviewed in this article are found to be HIV reverse transcriptase (RT).

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“…These compounds have shown variety of biological activities [1]. The C-3-dialkyl derivative of quinoline 2,4-diol, buchapine 1, was isolated from methanolic extract of the epigeal part of Haplophyllum bucharicum [2], H. tuberculatum [3,4], Euodia roxburghiana. Compound 2 was isolated from CH 2 Cl 2 -MeOH (1:1) extract of E. roxburghiana along with 1.…”

Section: Introductionmentioning

confidence: 99%