Composite coatings for implants and tissue engineering scaffolds

Gunputh, Urvashi; Le, Huirong

doi:10.1016/b978-0-08-100752-5.00006-8

Cited by 13 publications

(11 citation statements)

References 129 publications

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“…Coating the surface of medical implants to provide biocompatibility, bioactivity, antibacterial, anticancer, and bone-growth properties is a well-established technology [ 1 ]. Implantation leads to a risk of infection caused by bacteria attached to the implant surface.…”

Section: Introductionmentioning

confidence: 99%

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

et al. 2021

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Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm2 of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants.

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Section: Introductionmentioning

confidence: 99%

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

et al. 2021

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“…Electrochemical deposition is a process in which metals, oxides, or salts are deposited from a solution onto an electrically conducting surface by electrolysis. For the desired layer thickness and the synthesis of homogeneous coating, it is important to optimize multiple parameters such as electrolyte composition, pH of electrolytic, deposition time and temperature, and applied voltage, as well as anode and cathode materials ( Arulmani et al., 2018 ; Gunputh and Le, 2017 ). Zhao et al.…”

Section: Fabrication Strategies Of Membranesmentioning

confidence: 99%

Recent progress in nanomaterial-functionalized membranes for removal of pollutants

Nain¹,

Sangili²,

Hu³

et al. 2022

iScience

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“…In the field of tissue engineering, scaffolds and implant coatings are extensively studied and utilized to facilitate structural support and cellular adhesion and proliferation [ 90 , 105 , 106 ]. Nanoparticles are often incorporated into scaffolds and coatings to form composites with the purpose of increasing mechanical strength and surface properties to achieve the desired outcome out of the biomaterial [ 107 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Comparison between Janus-Base Nanotubes and Carbon Nanotubes: A Review on Synthesis, Physicochemical Properties, and Applications

Griger

Sands

Chen

2022

IJMS

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Research interest in nanoscale biomaterials has continued to grow in the past few decades, driving the need to form families of nanomaterials grouped by similar physical or chemical properties. Nanotubes have occupied a unique space in this field, primarily due to their high versatility in a wide range of biomedical applications. Although similar in morphology, members of this nanomaterial family widely differ in synthesis methods, mechanical and physiochemical properties, and therapeutic applications. As this field continues to develop, it is important to provide insight into novel biomaterial developments and their overall impact on current technology and therapeutics. In this review, we aim to characterize and compare two members of the nanotube family: carbon nanotubes (CNTs) and janus-base nanotubes (JBNts). While CNTs have been extensively studied for decades, JBNts provide a fresh perspective on many therapeutic modalities bound by the limitations of carbon-based nanomaterials. Herein, we characterize the morphology, synthesis, and applications of CNTs and JBNts to provide a comprehensive comparison between these nanomaterial technologies.

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Composite coatings for implants and tissue engineering scaffolds

Cited by 13 publications

References 129 publications

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

Recent progress in nanomaterial-functionalized membranes for removal of pollutants

Comparison between Janus-Base Nanotubes and Carbon Nanotubes: A Review on Synthesis, Physicochemical Properties, and Applications

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