Composite monetite/amorphous calcium phosphate bone cement promotes bone regeneration

Wang, Ziyu; Li, Qinghui; Ren, Shangxuan; Zhang, Hengshuo; Chen, Jie; Li, Aimin; Chen, Yunzhen

doi:10.1016/j.ceramint.2022.10.296

Cited by 8 publications

(2 citation statements)

References 62 publications

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“…Additionally, a CDHA/α-TCP biocomposite was prepared by α-TCP addition into a self-setting apatiteforming cement [1136]. Similarly, DCPA/ACP biocomposites were prepared by mixing DCPA and ACP powders followed by setting [1137]; however, it was not the case when carbonate apatite was added into a self-setting α-TCP [516]. Finally, it is interesting to mention the successful reinforcement of carbonate apatite porous blocks with newly prepared carbonate apatite crystals (i.e., the same compound) [1138].…”

Section: Biocomposites From Capo 4 Onlymentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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Section: Biocomposites From Capo 4 Onlymentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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“…Compared with crystalline phases, amorphous calcium phosphates (ACPs) draw great attention from researchers due to their unique characteristics. − Among its wide range (1.2–2.2) of Ca/P, the specific ACP under 1.5 have been widely studied for its thermally crystalline analogue is tricalcium phosphate (TCP), a universally utilized biomaterial. Benefiting from the short-range ordered structure, ACPs could transform into their crystalline analogue under appropriate thermal treatment and α-TCP was believed to be the first crystalline phase despite the fact that α-TCP was the high-temperature phase corresponding to β-TCP.…”

Section: Introductionmentioning

confidence: 99%

Competition and Neutralization: Thermally Induced Crystallization and Phase Evolution of Amorphous Calcium Phosphate with Cosubstitution of Larger and Smaller Divalent Cations

Wang

Yang

et al. 2023

ACS Omega

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The presented study evaluated the effect of cosubstitution of larger and smaller divalent cations on the thermally induced crystallization of amorphous calcium phosphate (ACP). The predesigned combinations of larger (Sr 2+ and Ba 2+ ) and smaller (Mg 2+ , Cu 2+ , and Co 2+ ) divalent cations were carried out and their effects on the thermodynamic equilibrium between α/βtricalcium phosphate (TCP) were outlined. The coexistence of larger and smaller divalent cations shielded the formation of α-TCP and shifted the thermodynamic equilibrium toward the β-TCP, which implied that the smaller cations dominated the crystalline phase. However, the retarded crystallization induced by the larger cations still remained and allowed ACP to maintain its amorphous nature partly or completely until a higher temperature.

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A curcumin sustained-release hydrogel prepared from Pickering emulsions stabilized by modified amorphous calcium phosphate nanoparticles

Cai,

Guo,

Liang

et al. 2024

Colloid Polym Sci

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Composite monetite/amorphous calcium phosphate bone cement promotes bone regeneration

Cited by 8 publications

References 62 publications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Competition and Neutralization: Thermally Induced Crystallization and Phase Evolution of Amorphous Calcium Phosphate with Cosubstitution of Larger and Smaller Divalent Cations

A curcumin sustained-release hydrogel prepared from Pickering emulsions stabilized by modified amorphous calcium phosphate nanoparticles

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