Composite nanofibers produced by modified needleless electrospinning

Košťáková, Eva Kuželová; Mészáros, László; Grégr, Jan

doi:10.1016/j.matlet.2009.08.014

Cited by 71 publications

(39 citation statements)

References 12 publications

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“…Thus, a variety of configurations have been reported that produce jets from free liquid surfaces, without the use of a spinneret. These include the use of a magnetic liquid in which "spikes" can be formed to concentrate field lines at points on a liquid surface [10], liquid-filled trenches [9], wetted spheres [11], cylinders [12][13][14] and disks [14], conical wires [15,16], rotating beaded wires [17] and gas bubbles rising through the liquid Accepted for publication in Chemical Engineering Journal, Dec 2011 surface [18,19]. In the case involving the use of a magnetic liquid, a jet density as high as 26 jets/cm 2 was reported [10].…”

Section: Introductionmentioning

confidence: 99%

“…All of these methods share the feature that liquid jets are launched from a free liquid surface, often with the aid of a device or disturbance that introduces curvature to the liquid interface. We refer to these processes collectively as "free surface electrospinning," although some have been previously described as "needleless electrospinning" [9][10][11][12][13][14][15][16], or "bubble electrospinning" [18,19], for example.…”

Section: Introductionmentioning

confidence: 99%

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Free surface electrospinning from a wire electrode

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Rutledge

2012

Chemical Engineering Journal

145

110

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Electrostatic jetting from a free liquid surface offers an alternative to conventional electrospinning in which jets are emitted from spinnerets. In this work we analyze a system in which a wire electrode is swept (in a rotary motion) through a bath containing a polymeric solution in contact with a high voltage, resulting in entrainment of the fluid, the formation of liquid droplets on the wire and electrostatic jetting from each liquid droplet. Solutions of polyvinylpyrrolidone in ethanol were used as test systems to evaluate each stage of the process.The volume of individual droplets on the wire were measured by photographic methods and correlated with the viscosity, density and surface tension of the liquid, and with system parameters such as electrode rotation rate and wire diameter. The local electric field in the absence of liquid entrainment was modeled using conventional electrostatics, and jet initiation was found to occur consistently at the angular position where the electric field exceeds a critical value of 34 kV/cm, regardless of rotation rate. Two operating regimes were identified. The first is an entrainment-limited regime, in which all of the entrained liquid is jetted from the wire electrode. The second regime is field-limited, in which the residence time of the wire electrode in an electric field in excess of the critical value is too short to deplete the fluid on the wire. The productivity of the system was measured and compared to the theoretical values of liquid entrainment. As expected, highest productivity occurred at high applied potentials and high rotation rates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Free surface electrospinning from a wire electrode

Forward

Rutledge

2012

Chemical Engineering Journal

145

110

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“…The prepared non-woven web is removable from the grounded collector as a sheet. There are numerous promising research activities in various relevant areas such as composites [6][7][8][9][10][11], sterile filtration [12], wound dressing [13,14], wound healing [15], tissue engineering [16][17][18][19] and semiconductors [20]. This technique is relatively new in the field of medical industry and ES is quite slightly known in pharmaceutical technology, where most of the relevant papers deal with sustained drug release [21].…”

Section: Introductionmentioning

confidence: 99%

Electrospun water soluble polymer mat for ultrafast release of Donepezil HCl

Nagy¹,

Nyúl²,

Wagner³

et al. 2010

Express Polym. Lett.

121

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Abstract. Electrostatic spinning (Electrospinning, ES) was applied to prepare Donepezil HCl loaded nanofibers as a potential orally dissolving dosage form. Electrospinning of water solutions of different polymers were performed in order to fabricate a consistent and removable web on the collector with ultra-fast dissolution in water based media. Poly(vinyl-alcohol) of low molecular weight was found to be the most appropriate for this purpose. Morphology of the prepared nanofibers was characterized by scanning electron microscope as a function of viscosity and drug content. Diameters of the fibers were between 100 and 300 nm with narrow distribution. In vitro drug release of the webs was immediate (less than 30 s) after immersion independently of their drug content owing to the formed huge surface area, while cast films with the same compositions and commercial tablets needed 30 min or more for complete dissolution. The developed technology for the preparation of orally dissolving web (ODW) formulations is a promising way for producing effective and acceptable dosage forms for children, older people and patients with dysphagia.

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“…oped in the textile industry [5][6][7][8], but in the recent years, applications have been published also in various biomedical fields such as wound dressing [9], wound healing [10], sterile filtration [11], tissue engineering [12,13] and drug delivery [14][15][16][17][18][19]. In former studies bioactive ingredients such as proteins and DNA have been embedded successfully in nanofibers mainly for tissue engineering purposes, while living prokaryotic cells were encapsulated by this technique mainly for industrial application in bioreactors utilizing their metabolic activity [20][21][22].…”

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confidence: 99%