Composite smart mesoporous silica nanoparticles as promising therapeutic and diagnostic candidates: Recent trends and applications

Saroj, Seema; Rajput, Sadhana J.

doi:10.1016/j.jddst.2018.01.014

Cited by 52 publications

(28 citation statements)

References 184 publications

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“…An interesting concept of late in anticancer interventions are theranostic systems (i.e., combining diagnostic and therapeutic elements in a single platform) in which chemically modified phytochemicals could play a significant role [ 6 , 7 ]. Theranostic agents are highly advanced systems that can function to monitor the accumulation of various compounds (including nanomedicines) at target sites, quantify triggered drug release, and detect malignant cells in order to deliver a chemotherapeutic agent to the targeted site [ 7 , 8 ]. The ability to simultaneously detect and treat cancer also reduces patient mortality as a result of early disease detection and immediate treatment [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention

et al. 2020

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Synthesis of a novel theranostic molecule for targeted cancer intervention. A reaction between curcumin and lawsone was carried out to yield the novel curcumin naphthoquinone (CurNQ) molecule (2,2′-((((1E,3Z,6E)-3-hydroxy-5-oxohepta-1,3,6-triene-1,7-diyl) bis(2-methoxy-4,1-phenylene))bis(oxy))bis(naphthalene-1,4-dione). CurNQ’s structure was elucidated and was fully characterized. CurNQ was demonstrated to have pH specific solubility, its saturation solubility increased from 11.15 µM at pH 7.4 to 20.7 µM at pH 6.8. This pH responsivity allows for cancer targeting (Warburg effect). Moreover, CurNQ displayed intrinsic fluorescence, thus enabling imaging and detection applications. In vitro cytotoxicity assays demonstrated the chemotherapeutic properties of CurNQ as CurNQ reduced cell viability to below 50% in OVCAR-5 and SKOV3 ovarian cancer cell lines. CurNQ is a novel theranostic molecule for potential targeted cancer detection and treatment.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention

et al. 2020

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“…Numerous reports have confirmed that, depending on the synthesis approach, silica nanoparticles have low cytotoxicity. Thus, the aim is to use the final product in medical trials and actually apply MSN in tumor-targeted delivery systems [113,114]. Reprinted from an open access source [16].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

et al. 2020

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In recent years, researchers focused their attention on mesoporous silica nanoparticles (MSNs) owing to the considerable advancements of the characterization methods, especially electron microscopy methods, which allowed for a clear visualization of the pore structure and the materials encapsulated within the pores, along with the X-ray diffraction (small angles) methods and specific surface area determination by Brunauer–Emmett–Teller (BET) technique. Mesoporous silica gained important consideration in biomedical applications thanks to its tunable pore size, high surface area, surface functionalization possibility, chemical stability, and pore nature. Specifically, the nature of the pores allows for the encapsulation and release of anti-cancer drugs into tumor tissues, which makes MSN ideal candidates as drug delivery carriers in cancer treatment. Moreover, the inner and outer surfaces of the MSN provide a platform for further functionalization approaches that could enhance the adsorption of the drug within the silica network and the selective targeting and controlled release to the desired site. Additionally, stimuli-responsive mesoporous silica systems are being used as mediators in cancer therapy, and through the release of the therapeutic agents hosted inside the pores under the action of specific triggering factors, it can selectively deliver them into tumor tissues. Another important application of the mesoporous silica nanomaterials is related to its ability to extract different hazardous species from aqueous media, some of these agents being antibiotics, pesticides, or anti-tumor agents. The purpose of this paper is to analyze the methods of MSN synthesis and related characteristics, the available surface functionalization strategies, and the most important applications of MSN in adsorption as well as release studies. Owing to the increasing antibiotic resistance, the need for developing materials for antibiotic removal from wastewaters is important and mesoporous materials already proved remarkable performances in environmental applications, including removal or even degradation of hazardous agents such as antibiotics and pesticides.

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“…Furthermore, apart from having targeting properties, the surface decoration exhibits reduced undesirable interaction with the internal organelles. 167 Moreover, Lu et al concluded 50nm particle size is the optimal size for the drug delivery by MSNs with respect to 30nm or even 200nm. 168 Whereas, He et al demonstrated that as the size of MSNs increases, the excretion from urine also increases correspondingly.…”

Section: Toxicity Biocompatibility and Biodegradation Of Msnsmentioning

confidence: 99%

Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting

Shah¹,

Rajput²

2019

IJPER

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Background: In nanotechnology, the most promising inorganic materials for cancer targeting are Mesoporous silica nanoparticles (MSNs). This review gives a state of the art description of current status and applications of surface functionalized MSNs in the field of cancer theranostics. It also gives a detailed description of surface decorated MSNs researched upon so far in various types of cancer and the benefits associated with these. Applications: Ease of surface functionalization also offers additional functionalities like cell recognition, absorption of specific biomolecules, improving cell interaction and cellular uptake that significantly modifies the in vitro and in vivo behavior of the drug. Therefore, they have proved to be effective in gene delivery and multi drug resistance cancer treatment. Though, their biocompatibility still remains debatable. Biodegradation of MSNs is quite simple and it is safely excreted through kidneys via silanoic acid formation. Moreover, the USFDA has already approved the silica under the 'GRAS' category which has further made MSNs a thrust area for research in cancer theranostics. Summary: This review summarizes the journey of multifunctional MSNs beginning with its origin, mechanism of formation of mesoporous structure with surface functionalization to till date and recent advances in the arena of cancer targeting.

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Composite smart mesoporous silica nanoparticles as promising therapeutic and diagnostic candidates: Recent trends and applications

Cited by 52 publications

References 184 publications

Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention

Synthesis and Properties of CurNQ for the Theranostic Application in Ovarian Cancer Intervention

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

Surface Decorated Mesoporous Silica Nanoparticles: A Promising and Emerging Tool for Cancer Targeting

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