Composite Sophora Colon-Soluble Capsule Ameliorates DSS-Induced Ulcerative Colitis in Mice via Gut Microbiota-Derived Butyric Acid and NCR+ ILC3

Chen, Mingjun; Feng, Yu; Gao, Lu; Lin, Ming-Xiong; Wang, Shi-da; Tong, Zhanqi

doi:10.1007/s11655-022-3317-1

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…Chen et al [ 94 ] found that the CSCC could attenuate inflammation of DSS-induced colitis in mice. In further studies, the researcher showed that CSCC could trigger the production of probiotics such as the Bacteroidales S24-7 genus.…”

Section: Traditional Medicine and Their Derivatives Act On Scfas To A...mentioning

confidence: 99%

“…The AKT-STAT3 pathway is an intracellular signaling pathway that has a significant impact on many biological processes, such as cell survival, proliferation, and angiogenesis. Activation of this pathway has a significant impact on UC [ 94 ]. In traditional medicine, some drugs can regulate the intestinal barrier to alleviate UC-related symptoms by regulating the AKT-STAT3 pathway [ 117 ].…”

Section: Traditional Medicine and Their Derivatives Act On Scfas To A...mentioning

confidence: 99%

“…CSCC provides an example of this evidence. Researchers have found that SCFAs promote NCR+ ILC3 proliferation and IL-22 production by activating the downstream AKT/STAT3 signaling pathway, leading to intestinal epithelial cell regeneration, AMP production, and intestinal epithelial cell mucus secretion [ 94 ]. Thus, regulating the AKT/STAT3 signaling pathway via generated SCFAs is an important mechanism employed by some traditional medicines in treating colonic inflammation.…”

Section: Traditional Medicine and Their Derivatives Act On Scfas To A...mentioning

confidence: 99%

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Short Chain Fatty Acids: Essential Weapons of Traditional Medicine in Treating Inflammatory Bowel Disease

Yao,

Liu,

et al. 2024

Molecules

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Inflammatory bowel disease (IBD) is a chronic and recurrent intestinal inflammatory disease, mainly including Crohn’s disease (CD) and ulcerative colitis (UC). In recent years, the incidence and prevalence of IBD have been on the rise worldwide and have become a significant concern of health and a huge economic burden on patients. The occurrence and development of IBD involve a variety of pathogenic factors. The changes in short-chain fatty acids (SCFAs) are considered to be an important pathogenic mechanism of this disease. SCFAs are important metabolites in the intestinal microbial environment, which are closely involved in regulating immune, anti-tumor, and anti-inflammatory activities. Changes in metabolite levels can reflect the homeostasis of the intestinal microflora. Recent studies have shown that SCFAs provide energy for host cells and intestinal microflora, shape the intestinal environment, and regulate the immune system, thereby regulating intestinal physiology. SCFAs can effectively reduce the incidence of enteritis, cardiovascular disease, colon cancer, obesity, and diabetes, and also play an important role in maintaining the balance of energy metabolism (mainly glucose metabolism) and improving insulin tolerance. In recent years, many studies have shown that numerous decoctions and natural compounds of traditional Chinese medicine have shown promising therapeutic activities in multiple animal models of colitis and thus attracted increasing attention from scientists in the study of IBD treatment. Some of these traditional Chinese medicines or compounds can effectively alleviate colonic inflammation and clinical symptoms by regulating the generation of SCFAs. This study reviews the effects of various traditional Chinese medicines or bioactive substances on the production of SCFAs and their potential impacts on the severity of colonic inflammation. On this basis, we discussed the mechanism of SCFAs in regulating IBD-associated inflammation, as well as the related regulatory factors and signaling pathways. In addition, we provide our understanding of the limitations of current research and the prospects for future studies on the development of new IBD therapies by targeting SCFAs. This review may widen our understanding of the effect of traditional medicine from the view of SCFAs and their role in alleviating IBD animal models, thus contributing to the studies of IBD researchers.

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Section: Traditional Medicine and Their Derivatives Act On Scfas To A...mentioning

confidence: 99%

Section: Traditional Medicine and Their Derivatives Act On Scfas To A...mentioning

confidence: 99%

Section: Traditional Medicine and Their Derivatives Act On Scfas To A...mentioning

confidence: 99%

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Short Chain Fatty Acids: Essential Weapons of Traditional Medicine in Treating Inflammatory Bowel Disease

Yao,

Liu,

et al. 2024

Molecules

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The emerging role of the gut microbiota and its application in inflammatory bowel disease

Wang,

Peng,

Cai

et al. 2024

Biomedicine & Pharmacotherapy

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Period circadian clock 3 is crucial for regulation of IL-22-producing type 3 innate lymphoid cells by flavonoids from Shen Ling Bai Zhu San to alleviate colitis

Qu,

Ma,

Zhang

et al. 2025

International Journal of Biological Macromolecules

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Composite Sophora Colon-Soluble Capsule Ameliorates DSS-Induced Ulcerative Colitis in Mice via Gut Microbiota-Derived Butyric Acid and NCR+ ILC3

Cited by 5 publications

References 55 publications

Short Chain Fatty Acids: Essential Weapons of Traditional Medicine in Treating Inflammatory Bowel Disease

Short Chain Fatty Acids: Essential Weapons of Traditional Medicine in Treating Inflammatory Bowel Disease

The emerging role of the gut microbiota and its application in inflammatory bowel disease

Period circadian clock 3 is crucial for regulation of IL-22-producing type 3 innate lymphoid cells by flavonoids from Shen Ling Bai Zhu San to alleviate colitis

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