Composition and bioactivity of calcium phosphate coatings on anodic oxide nanotubes formed on pure Ti and Ti-6Al-4V alloy substrates

Yao, Qianting; Jiang, Yingying; Tan, Shuo; Fu, Xiaoyi; Li, Bo; Liu, Lijia

doi:10.1016/j.msec.2020.110687

Cited by 14 publications

(10 citation statements)

References 75 publications

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“…In particular, the use of hydroxyapatite-based coatings is widespread [10,11], as they are close in composition to the bone mineral phase and show high bioactivity [12]. Such coatings are now clinically used for cementless arthroplasty, with partially or fully coated femoral stem [13,14].…”

Section: Introductionmentioning

confidence: 99%

Baicalein-modified hydroxyapatite nanoparticles and coatings with antibacterial and antioxidant properties

Palierse

Hélary

Krafft

et al. 2021

Materials Science and Engineering: C

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Aseptic loosening and bacterial infections are the two main causes of failure for metallic implants used for joint replacement. A coating that is both bioactive and possesses antimicrobial properties may address such shortcomings and improve the performance of the implant. We have sought to study the properties of combining hydroxyapatite-based nanoparticles or coatings with baicalein, a plant-extracted molecule with both antibacterial and antioxidant properties. (B-type) carbonated hydroxyapatite nanoparticles prepared by a chemical wet method could subsequently adsorbed by soaking in a baicalein solution. The amount of adsorbed baicalein was determined to be 63 mg.g -1 by thermogravimetric measurements. In a second approach, baicalein was adsorbed on a biomimetic calciumdeficient hydroxyapatite planar coating (12 m thick) deposited on Ti6Al4V alloy from an aqueous solution of calcium, phosphate, sodium and magnesium salts. Soaking of the hydroxyapatite coated on titanium alloy in a baicalein solution induced partial dissolution/remodeling of the upper surface of the coating. However, the observed remodeling of the surface was much more pronounced in the presence of a baicalein solution, compared to pure water. The presence of adsorbed baicalein on the HAp layer, although it could not be precisely quantified, was assessed by XPS and fluorescence analysis. Planar coatings exhibited significant antibacterial properties against Staphylococcus epidermidis. Baicaleinmodified nanoparticles exhibited significant antioxidant properties. These results illustrate the potential of hydroxyapatite used as a carrier for natural biologically-active molecules and also discuss the challenges associated with their applications as antibacterial agents.

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Section: Introductionmentioning

confidence: 99%

Baicalein-modified hydroxyapatite nanoparticles and coatings with antibacterial and antioxidant properties

Palierse

Hélary

Krafft

et al. 2021

Materials Science and Engineering: C

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“…Ideal bioactive coatings have the following properties: osteoinductivity, osteoconductivity [ 4 ], biocompatibility, an anti-inflammatory response [ 16 ], antimicrobial activity [ 17 , 18 ], corrosion mitigation, as well as suitable mechanical properties [ 19 ]. They can be composed of bioactive materials; various polymers [ 20 ], hydroxyapatite (HA) [ 21 ], calcium phosphate (CaP), titania nanotubes (TNTs) [ 22 ], carbon nanomaterials [ 23 ], etc. ; they can also contain active substances that are released from their structure into the local environment [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings.

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“…Due to the larger surface area, TNTs were used in various osteogenic materials. EA is a surface modification approach that applied (Yao et al, 2020). The cell experiment showed that the nanotubes with a higher HA content were suitable for cell adhesion.…”

Section: Coatings Of Various Nanostructuresmentioning

confidence: 99%

“…EA is a surface modification approach that applied an external voltage to the metal plate in the electrolyte to grow a specific structure orderly. Yao et al fabricated anodic oxide nanotubes and deposited calcium phosphate (CaP) on the surface of Ti and Ti-6Al-4V ( Yao et al, 2020 ). The cell experiment showed that the nanotubes with a higher HA content were suitable for cell adhesion.…”

Section: Prevention Of Aseptic Implant Looseningmentioning

confidence: 99%

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

et al. 2021

Front. Bioeng. Biotechnol.

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Titanium and its alloys are dominant material for orthopedic/dental implants due to their stable chemical properties and good biocompatibility. However, aseptic loosening and peri-implant infection remain problems that may lead to implant removal eventually. The ideal orthopedic implant should possess both osteogenic and antibacterial properties and do proper assistance to in situ inflammatory cells for anti-microbe and tissue repair. Recent advances in surface modification have provided various strategies to procure the harmonious relationship between implant and its microenvironment. In this review, we provide an overview of the latest strategies to endow titanium implants with bio-function and anti-infection properties. We state the methods they use to preparing these efficient surfaces and offer further insight into the interaction between these devices and the local biological environment. Finally, we discuss the unmet needs and current challenges in the development of ideal materials for bone implantation.

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Composition and bioactivity of calcium phosphate coatings on anodic oxide nanotubes formed on pure Ti and Ti-6Al-4V alloy substrates

Cited by 14 publications

References 75 publications

Baicalein-modified hydroxyapatite nanoparticles and coatings with antibacterial and antioxidant properties

Baicalein-modified hydroxyapatite nanoparticles and coatings with antibacterial and antioxidant properties

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

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