Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

Jang, Daehan; Lee, Jun-Woo; Eom, Seung Hee; Lee, Seung Min; Gil, Jinsu; Lim, Heung Bin; Hyun, Tae Kyung

doi:10.7324/japs.2016.60322

Cited by 15 publications

(16 citation statements)

References 29 publications

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“…), which is also in agreement with the studies of Shohael et al [21]. According to Jang et al [22] the fruits of E. senticosus collected in Korea have contained the TPC and TFC in the range of 197.9–334.3 mg/g and 41.2–203.7 mg/g.…”

Section: Resultssupporting

confidence: 90%

Phytochemical Content and Pharma‐Nutrition Study on Eleutherococcus senticosus Fruits Intractum

Załuski

Olech

Galanty

et al. 2016

Oxidative Medicine and Cellular Longevity

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In the past two decades public interest in herbal products has increased significantly in Europe, especially in the plant-based products from non-European traditions. Eleutherococcus senticosus has been used for the treatment of inflammatory diseases, anemia, and rheumatoid arthritis. The Eleutherococcus senticosus fruits intractum was examined for the content of phenolic acids (LC-ESI-MS/MS), minerals (AAS), TPC, and TFC (spectrophotometric assay). The antioxidant activity was determined using free radical scavenging assay and TLC-DB-DPPH∗ dot-blot test. An anti-Hyal activity was evaluated by the spectrophotometric assay method. Cytotoxicity towards HL-60, HL-60/MX1, HL-60/MX2, CEM/C1, and CCRF/CEM leukemic cell lines was done using trypan blue test. Among eight phenolic acids, trans-caffeic acid was found in the largest amount (41.2 mg/g DE). The intractum presented a high amount of macroelements (Ca, Mg, K; 1750, 1300, and 21000 mg/kg) and microelements (Fe, Mn; 32.7, 54.3 mg/kg), respectively. The content of TPC and TFC was 130 and 92 mg/g DE, respectively. The intractum showed anti-Hyal activity (2.16–60%) and an antioxidant capacity (EC50; 52 μg/mL). The intractum most strongly inhibited the growth of HL-60, HL-60/MX1, and CCRF/CEM. A better understanding of the intractum health benefits is important in order to increase its utility and enrich dietary sources of health promoting compounds.

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Section: Resultssupporting

confidence: 90%

Phytochemical Content and Pharma‐Nutrition Study on Eleutherococcus senticosus Fruits Intractum

Załuski

Olech

Galanty

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…Results obtained by Jang et al (2016) suggest that the fruit of Siberian ginseng may be a good candidate as a source of antioxidant and antimicrobial ingredients -antimicrobial activity was observed against Kocuria rhizophila (MIC = 125 µg/mL), Micrococcus luteus (MIC = 500 µg/mL), and Escherichia coli (MIC = 63 µg/mL). We determined antibacterial effect of Eleutherococcus senticosus on K. рneumonia (10.5 mm).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of 50 plant extracts

et al. 2019

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Antibacterial activity of plants is a subject of interest in the search for new antibiotics and fungicidal preparations. This article analyzes the effectiveness of the action of extracts of plants on microorganisms: six species of bacteria (Salmonella typhimurium, Listeria monocytogenes, Escherichia coli, Klebsiella pneumoniae, Corynebacterium xerosis, Proteus vulgaris) and one fungus (Candida albicans). For the assay, we used herbal material of 50 species (seeds, grass, shoots, leaves, compound fruit, peel) obtained at different periods of the growing season. We studied Levisticum officinale, Petroselinum crispum, Nerium oleander, Vinca minor, Eleutherococcus senticosus, E. sieboldianus, Yucca filamentosa, Artemisia annua, Echinacea purpurea, Matricaria recutita, Tanacetum vulgare, Betula pendula, Corylus avellana, Buxus sempervirens, Humulus lupulus, Crassula ovata, Bryophyllum daigremontianum, Juniperus communis, Platycladus orientalis, Cycas revoluta, Calluna vulgaris, Rhododendron ferrugineum, Ceratonia siliqua, Trigonella foenum-graecum, Ribes nigrum, Phellinus tuberculosus, Lavandula angustifolia, Melissa officinalis, Monarda fistulosa, Origanum vulgare, Salvia sclarea, Laurus nobilis, Punica granatum, Hibiscus rosa-sinensis, Menispermum dauricum, Ficus benjamina, Morus alba, Paeonia suffruticosa, Picea abies, Adonis vernalis, Amelanchier ovalis, Prunus armeniaca, Crataegus monogyna, Citrus sinensis, Salix babylonica, Bergenia crassifolia, Schisandra chinensis, Taxus baccata and Xanthoria parietina. The alcohol tincture was filtered with sterile multi-layer gauze disc filters. Before the discs were put on the surface of agar with inoculation of the corresponding culture, they were dried in a sterile laminar box under ultraviolet rays. Antibacterial activity of various tinctures was determined by the disk diffusion method in agar with the measurement of the diameter of the growth suppression zone of the culture using a template ruler. Maximum inhibiting effect was achieved for Punica granatum on K. рneumonia, L. monocytogenes, S. typhimurium, P. vulgaris, C. хerosis and E. сoli, Lavandula angustifolia – on P. vulgaris, K. рneumonia and S. typhimurium, Echinacea purpurea – on C. аlbicans, E. сoli, P. vulgaris, K. рneumonia, Bergenia crassifolia – on P. vulgaris, K. pneumonia and S. typhimurium.

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“…Meanwhile, other groups of secondary metabolites have also been found to have antioxidant properties (Matkowski 2008;Jang et al 2016). For example, it was revealed that some ginsenosides from P. ginseng protect rabbit pulmonary endothelium tissue from ROS toxicity .…”

Section: Introductionmentioning

confidence: 99%

The content of triterpene saponins and phenolic compounds in American ginseng hairy root extracts and their antioxidant and cytotoxic properties

Kochan

Szymańska

Wielanek

et al. 2019

Plant Cell Tiss Organ Cult

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Panax quinquefolium is a perennial herb of the Araliaceae family native to North America. Its roots have been used in traditional and Chinese medicine. The aim of this study was to determine the phenolic profile of methanolic extracts of P. quinquefolium hairy roots cultivated in flasks and a bioreactor, as well as extracts from the roots of three-year-old field-grown plants. Additionally, the phenol and ginsenoside components of the tested extracts were identified by HPLC, and their antioxidant and cytotoxic properties were evaluated. The antioxidant effect was evaluated by FRAP (ferric reducing antioxidant power), and ABTS ([2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) cation scavenging tests, and their effect on the viability of the glioblastoma cell (T98G) line was measured using the 3-(4,5-dimethylthazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The LC-MS/MS analysis revealed the presence of 16 phenolic compounds identified as phenolic acids (ten compounds) or flavonoids (six compounds). The highest phenol content was observed in the transformed roots of flask-grown P. quinquefolium (1.6 mg g −1 d.w.), followed by these grown in the bioreactor (1.1 mg g −1 d.w.). However, the highest ginsenoside content was found in the roots of the naturally-cultivated plants (67.6 mg g −1 d.w.). The methanolic extracts from hairy root culture of P. quinquefolium appear to have significant antioxidant and cytotoxic potential. Such transformed American ginseng root cultures could represent a potential source of bioactive metabolites for the food or pharmaceutical industry. Key message First time phenolic compound level, antioxidant and cytotoxic properties were estimated in hairy root cultures of Panax quinquefolium cultivated in flasks and nutrient sprinkle bioreactor. Ginsenosides content was also determined.

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Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

Cited by 15 publications

References 29 publications

Phytochemical Content and Pharma‐Nutrition Study on Eleutherococcus senticosus Fruits Intractum

Phytochemical Content and Pharma‐Nutrition Study on Eleutherococcus senticosus Fruits Intractum

Antimicrobial activity of 50 plant extracts

The content of triterpene saponins and phenolic compounds in American ginseng hairy root extracts and their antioxidant and cytotoxic properties

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