Composition, <i>in vitro</i> Cytotoxicity, and Anti-mildew Activities of the Leaf Essential Oil of <i>Machilus thunbergii</i> from Taiwan

Su, Yu-Chang; Hsu, Kuan-Ping; Li, Shu-Ching; Ho, Chyi-Chen

doi:10.1177/1934578x1501001153

Cited by 10 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cytotoxic activities of T. yemense leaf essential oils is likely due to the relatively high concentrations of known cytotoxic components such as ( E )-caryophyllene (MCF-7 [ 57 ], HT-29 [ 58 , 59 ], other cell lines [ 56 ]) α-humulene (MCF-7 [ 57 ], HT-29 [ 58 , 59 ], other cell lines [ 60 , 61 ]) δ-cadinene [ 56 ], caryophyllene oxide (MCF-7 [ 57 ], other cell lines [ 62 ]), and α-cadinol (MCF-7, HT-29 [ 63 ], other cell lines [ 50 ]). Furthermore, ( E )-caryophyllene has been shown to potentiate the cytotoxic activities of other sesquiterpenoids [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial, Antioxidant, and Cytotoxic Activities of Ocimum forskolei and Teucrium yemense (Lamiaceae) Essential Oils

et al. 2017

View full text Add to dashboard Cite

Background: Ocimum forskolei and Teucrium yemense (Lamiaceae) are used in traditional medicine in Yemen. Methods: The chemical composition, antimicrobial, antioxidant and cytotoxic activities of the essential oils isolated from the leaves of Ocimum forskolei Benth. (EOOF) and two different populations of Teucrium yemense Deflers., one collected from Dhamar province (EOTY-d), and another collected from Taiz (EOTY-t) were investigated. The antimicrobial activities of the oils were evaluated against several microorganisms with the disc diffusion test or the broth microdilution test. The essential oils were screened for in-vitro cytotoxic activity against human tumor cells. EOOF and EOTY-d were screened for free-radical-inhibitory activity using the DPPH radical scavenging assay. Results: Sixty-four compounds were identified in (EOOF) representing 100% of the oil content with endo-fenchol (31.1%), fenchone (12.2%), τ-cadinol (12.2%), and methyl (E)-cinnamate (5.1%) as the major compounds. In EOTY-d, 67 compounds were identified, which made up 91% of the total oil. The most abundant constituents were (E)-caryophyllene (11.2%), α-humulene (4.0.%), γ-selinene (5.5%), 7-epi-α-selinene (20.1%), and caryophyllene oxide (20.1%), while the major compounds in EOTY-t were α-pinene (6.6%), (E)-caryophyllene (19.1%) α-humulene (6.4%), δ-cadinene (6.5%), caryophyllene oxide (4.3%), α-cadinol (9.5%), and shyobunol (4.6%). The most sensitive microorganisms for EOOF were B. subtilis, S. aureus, and C. albicans with inhibition zones of 34, 16, and 24 mm and MIC values of, 4.3 mg/mL, 4.3 mg/mL, and 8.6 mg/mL, respectively. EOTY-t showed antimicrobial activity against S. aureus, B. cereus, A. niger, and B. cinerea with MIC values of 0.156, 0.156, 0.313 and 0.313 mg/mL, respectively. Neither essential oil showed remarkable radical inhibition (IC50 = 31.55 and 31.41 μL/mL). EOTY-d was active against HT-29 human colorectal adenocarcinoma cell lines with IC50 = 43.7 μg/mL. Consistent with this, EOTY-t was active against both MCF-7 and MDA-MB-231 human breast adenocarcinoma cells. Conclusions: The antimicrobial activity of Ocimum forskolei essential oil against B. subtilis and C. albicans is consistent with its traditional use in Yemeni traditional medicine to treat skin infections. Both O. forskolei and T. yemense show wide variations in their respective essential oil compositions; there remains a need to investigate both species botanically, genetically, and phytochemically more comprehensively.

show abstract

Section: Resultsmentioning

confidence: 99%

Antimicrobial, Antioxidant, and Cytotoxic Activities of Ocimum forskolei and Teucrium yemense (Lamiaceae) Essential Oils

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Frankincense ( Boswellia carteri ) essential oil is also rich in β-caryophyllene and showed comparable cytotoxic activity. Sesquiterpene hydrocarbons, such as β-caryophyllene and α-humulene, have shown moderate cytotoxic activity against several human tumor cell lines [ 11 , 13 , 24 ]; the relatively high concentrations of sesquiterpene hydrocarbons in the essential oils of sub-cluster 3b may account for the observed moderate cytotoxicities.…”

Section: Discussionmentioning

confidence: 99%

Antifungal and Cytotoxic Activities of Sixty Commercially-Available Essential Oils

et al. 2018

View full text Add to dashboard Cite

There is an urgent and unmet need for new antifungal therapies. Global fungal infection rates continue to rise and fungal infections pose increasing burdens on global healthcare systems. Exacerbating the situation, the available antifungal therapeutic arsenal is limited and development of new antifungals has been slow. Current antifungals are known for unwanted side effects including nephrotoxicity and hepatotoxicity. Thus, the need for new antifungals and new antifungal targets is urgent and growing. A collection of 60 commercially-available essential oils has been screened for antifungal activity against Aspergillus niger, Candida albicans, and Cryptococcus neoformans, as well as for cytotoxic activity against MCF-7 and MDA-MB-231 human breast tumor cell lines; the chemical compositions of the essential oils have been determined by gas chromatography-mass spectrometry (GC-MS). Ten essential oils showed remarkable antifungal and cytotoxic activities: Indian, Australian, and Hawaiian sandalwoods; melissa; lemongrass; cilantro; cassia; cinnamon; patchouli; and vetiver.

show abstract

“…The cortex of M. thunbergii, which has been consumed as traditional herbal medicine for treatment of leg edema and abdominal distension and pain for a long period of time [19][20][21]. Isoquinoline alkaloids have been obtained from the root , lignin, catechin and polysaccharides from the heartwood, polysaccharides, and essential oils from the leaves, volatile components from the fruits, and lignans and neolignans from the cortex [22][23][24]. Some of these compounds are antioxidants with hepatoprotective, and anti-bacterial activities, while a few other show inhibitory effects on nitric oxide synthesis inactivated macrophages and neuroprotective activity against glutamate-induced neurotoxicity [22,25,26].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity and synergistic effects between Machilus thunbergii ethanol extract and antibiotics against oral pathogens

Jang¹,

Choi²,

Cha³

2018

Dent Oral Craniofac Res

View full text Add to dashboard Cite

The cortex of Machilus thunbergii, which has been consumed as traditional herbal medicine for treatment of leg edema and abdominal distension and pain for a long period of time. In this study, the combination effect of M. thunbergii ethanol extract (MTEE) was evaluated against oral bacteria, either alone or with antibiotics, via broth dilution method and checkerboard and time kill assay. MIC/MBC values for MTEE against all the tested bacteria ranged between 12.5-50/50-200 microg/ mL, for ampicillin 0.0625-8/0.125-32 microg/mL and for gentamicin 4-128/8-512 microg/mL respectively. Furthermore, the MIC and MBC were reduced to one half-eighth as a result of the combination of MTEE with antibiotics. 1-6 hours of treatment with 1/2 MIC of MTEE with 1/2 MIC of antibiotics resulted from an increase of the rate of killing in units of CFU/mL to a greater degree than was observed with alone. These results suggest that the MTEE is important in the antibacterial actions of oral pathogens agents.

show abstract

Composition, in vitro Cytotoxicity, and Anti-mildew Activities of the Leaf Essential Oil of Machilus thunbergii from Taiwan

Cited by 10 publications

References 24 publications

Antimicrobial, Antioxidant, and Cytotoxic Activities of Ocimum forskolei and Teucrium yemense (Lamiaceae) Essential Oils

Antimicrobial, Antioxidant, and Cytotoxic Activities of Ocimum forskolei and Teucrium yemense (Lamiaceae) Essential Oils

Antifungal and Cytotoxic Activities of Sixty Commercially-Available Essential Oils

Antibacterial activity and synergistic effects between Machilus thunbergii ethanol extract and antibiotics against oral pathogens

Contact Info

Product

Resources

About