Composition Studies on some Varieties of Tobacco and their Smoke: I. Major Components in Smoke Condensate

Matsushima, Sanji; lshiguro, Shigeo; Sugawara, Shirô

doi:10.2478/cttr-2013-0466

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…Thus, integrity of the Zilkey et al data set ( 60) is questionable. Matsushima et al quantified the MS deliveries/puff of six single blend component cigarettes, two each of fluecured, Burley, and Turkish tobaccos (61). The authors identified 10 MS smoke constituents which they considered have their origin from carbohydrate pyrolysis, and these are listed in Table 3.…”

Section: B Effect Of Sugars In the Tobacco Blend On Ms Smoke Acetalde...mentioning

confidence: 99%

Acetaldehyde in Mainstream Tobacco Smoke: Formation and Occurrence in Smoke and Bioavailability in the Smoker

Seeman

Dixon

Haussmann

2002

Chem. Res. Toxicol.

117

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A review is presented of the scientific literature on the effects of sugars (mono- and disaccharides), when used as tobacco additives, on the formation of acetaldehyde in mainstream (MS) smoke and the potential bioavailablity of MS smoke acetaldehyde derived from sugars to the smoker. The experimental data supports the following conclusions. Sugars, e.g., D-glucose, D-fructose, and sucrose, do not produce greater yields of acetaldehyde in MS smoke than are produced from tobacco itself on a weight-for-weight basis. A variety of studies suggests that natural tobacco polysaccharides, including cellulose, are the primary precursors of acetaldehyde in MS smoke. In a number of different studies using commercial cigarette brands, MS smoke yields of acetaldehyde correlate (r > 0.9) with both MS smoke "tar" and carbon monoxide. MS smoke acetaldehyde yields are affected more by cigarette design characteristics that influence total smoke production, such as filter ventilation, filtration, and paper porosity, than by reducing sugars. MS smoke acetaldehyde deposits primarily in the upper respiratory tract, including the mouth, of the smoker. Acetaldehyde is rapidly metabolized by aldehyde dehydrogenase in the blood and elsewhere in the body, including at the blood-brain barrier. Tobacco sugar-derived MS smoke acetaldehyde from commercial cigarettes is unlikely to result in direct central nervous system effects on the smoker.

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Section: B Effect Of Sugars In the Tobacco Blend On Ms Smoke Acetalde...mentioning

confidence: 99%

Acetaldehyde in Mainstream Tobacco Smoke: Formation and Occurrence in Smoke and Bioavailability in the Smoker

Seeman

Dixon

Haussmann

2002

Chem. Res. Toxicol.

117

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“…The combustion of cigarette tobacco filler during cigarette smoking creates an aerosol containing numerous chemical compounds (4,5). Among the thousands of reported chemicals generated during smoking are several specific classes of hazardous compounds that merit concern (3,4,(6)(7)(8)(9)(10). The International Agency for Research on Cancer (IARC) groups individual chemicals and chemical mixtures according to their carcinogenicity toward humans.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Volatile Organic Compounds in Mainstream Cigarette Smoke

Polzin

Kosa-Maines

Ashley

et al. 2007

Environ. Sci. Technol.

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Mainstream cigarette smoke is a complex aerosol containing more than 4400 chemicals. The proliferation of new brands has necessitated development of faster and more reliable methods capable of analyzing a wide range of compounds in cigarette smoke. Although the International Agency for Research on Cancer has classified whole cigarette smoke as a human carcinogen, many of the individual chemicals are themselves highly biologically active as carcinogens, teratogens, or have implications for cardiovascular disease. Among these chemicals are many volatile organic compounds (VOCs), e.g., benzene, ethylbenzene, and styrene. To analyze VOCs in mainstream cigarette smoke, we developed a novel headspace collection technique using polyvinylfluoride bags for sample collection followed by cannula transfer to evacuated standard 20-mL auto sampler vials. Coupling collection of the vapor-phase cigarette smoke with automated analysis by solid-phase microextraction and gas chromatography/mass spectrometry enabled us to routinely quantify selected VOCs in mainstream cigarette smoke. This technique has similar reproducibility to previous cold trap and impinger collection methods with significantly higher sample throughput and virtually no solvent waste. In this report we demonstrate the method's analytical capabilities by quantitatively analyzing 13 selected VOCs in mainstream cigarette smoke from top-selling domestic brands.

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“…amino acid metabolism [1][2][3]. During tobacco curing, these SEs can release a broad range of aliphatic acids, including 3-methylvaleric acid and 3-methylbutyric acid, which substantially contribute to the sensory quality of tobacco smoke [4,5]. Some SEs have shown sensory, antibacterial, insecticidal, moisturizing, and plant growth-regulating properties [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Sucrose esters (SEs) constitute a significant class of compounds present on the tobacco surface, and they are entirely biosynthesized in glandular trichomes through sucrose and aliphatic acids produced via branched‐chain amino acid metabolism [1–3]. During tobacco curing, these SEs can release a broad range of aliphatic acids, including 3‐methylvaleric acid and 3‐methylbutyric acid, which substantially contribute to the sensory quality of tobacco smoke [4, 5]. Some SEs have shown sensory, antibacterial, insecticidal, moisturizing, and plant growth‐regulating properties [6–8].…”

Section: Introductionmentioning

confidence: 99%

Separation, identification, and structural characterization of sucrose ester isomers from tobacco

Zhu,

Yuan,

Xie

et al. 2023

J of Separation Science

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Sucrose esters (SEs) are crucial tobacco smoke flavor precursors and play a significant role in tobacco's functionality. Due to their structural complexity, the separation and analysis of SEs in tobacco remain a major challenge, and massive structures of SEs have not yet been fully identified. In this study, the fractions enriched in SEs were obtained from oriental and flue‐cured tobacco through a series of pretreatments, and two types of SEs (Types I and II) were distinguished by liquid chromatography‐tandem mass spectrometry (LC‐MSn) analysis, with Type II SEs newly characterized in tobacco. Five groups of main SEs were further purified using preparative high‐performance LC (HPLC) coupled to an evaporative light scattering detector, and their structures were characterized by nuclear magnetic resonance spectrometry techniques including 1H, 13C, correlation spectroscopy, heteronuclear single quantum correlation, and heteronuclear multiple bond correlation. By combining LC‐MSn and nuclear magnetic resonance spectrometry, the structures of eight SE isomers were finally proposed, of which four were newly identified. These findings further enhance the understanding of the structural diversity of SEs in tobacco, serving as a valuable reference for future research on the elucidation, synthesis, and metabolism of SEs.

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Composition Studies on some Varieties of Tobacco and their Smoke: I. Major Components in Smoke Condensate

Cited by 9 publications

References 7 publications

Acetaldehyde in Mainstream Tobacco Smoke: Formation and Occurrence in Smoke and Bioavailability in the Smoker

Acetaldehyde in Mainstream Tobacco Smoke: Formation and Occurrence in Smoke and Bioavailability in the Smoker

Analysis of Volatile Organic Compounds in Mainstream Cigarette Smoke

Separation, identification, and structural characterization of sucrose ester isomers from tobacco

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