Compounded research challenges amid the COVID-19 pandemic

Inhaled milrinone for sick COVID-19 cohort: A pathophysiology driven hypothesis!

“…An improved comprehension of the COVID-19 pathobiophysiology should be closely backed by the meticulous investigation of the mechanistically related and specific drug therapies aimed at ameliorating the root cause of the disease process. Amidst the intensifying research challenges in the ongoing pandemic where a part of fraternity is impressing upon the fact that the plural of anecdotes does not classify as data [13] , [14] , the importance of rapidly responding to the dynamic challenging clinical landscape cannot be overemphasized wherein a judicious application of more familiar medications such as iMil can be helpful in mitigating the ever growing concerns of COVID-19 attributable morbidity and mortality.…”

COVID-19 research and publishing: Advance ambitiously, but cautiously, in 2021

“…Rather than letting down their guard and being further negatively impacted by the pandemic, better self-defense mechanisms -including through greater awareness of the risks in academic publishing -to safe-guard themselves against exposure to, and reliance on, poor or incorrect science or misinformation that may exist in social media, preprints or peer-reviewed literature, is needed. Fortified protection and awareness is not equivalent to laziness, although it is perfectly understandable that in these trying times, motivation may be lacking, and that prior research objectives might be more difficult to achieve under constrained work and research environments (38) . There are also multiple practical ethical challenges underlying medical aspects of COVID-19 research (39) .…”

Dexmedetomidine in COVID-19: probing promises with prudence!

“…However, withdrawal can be prevented with the meticulous use of drug or mitigated with clonidine [5]. Nevertheless, delving into the current scenario of the riddling uncertainties in staging an ideal management plan against the novel intriguing viral enemy [10,11], I get reminded of the Bertrand Russell quote: When one admits that nothing is certain one must, I think, also add that some things are more nearly certain than others...…”