Compounds affecting predation by and viability of predatory bacteria

Mitchell, Robert J.; Mun, Wonsik; Mabekou, Sandrine Soh; Jang, Hyochan; Choi, Seong Yeol

doi:10.1007/s00253-020-10530-1

Cited by 5 publications

(2 citation statements)

References 62 publications

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“…In short, PHA defective mutants might have unexpected metabolic consequences 42 – 46 influencing predation activity, and research in this field could help to identify and eventually overcome predation resistance factors in P. aeruginosa . It is worth noting that the prey range (intra- or interspecies range) does not depend only on the prey susceptibility but also on the predator specificity, which highlights the importance of specific predator–prey susceptibility testing, as their interaction and co-evolution may overcome predation and resistance, respectively 47 , 48 . A promising perspective for future work is trying to see if predation host-specificity and predation rate might differ when predators are propagated in bacterial species/clones isolated from closely related or different niches.…”

Section: Discussionmentioning

confidence: 99%

Strain-specific predation of Bdellovibrio bacteriovorus on Pseudomonas aeruginosa with a higher range for cystic fibrosis than for bacteremia isolates

Saralegui

Herencias

Halperin

et al. 2022

Sci Rep

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This work aimed to evaluate the predatory activity of Bdellovibrio bacteriovorus 109J on clinical isolates of Pseudomonas aeruginosa selected from well-characterized collections of cystic fibrosis (CF) lung colonization (n = 30) and bloodstream infections (BSI) (n = 48) including strains selected by genetic lineage (frequent and rare sequence types), antibiotic resistance phenotype (susceptible and multidrug-resistant isolates), and colony phenotype (mucoid and non-mucoid isolates). The intraspecies predation range (I-PR) was defined as the proportion of susceptible strains within the entire collection. In contrast, the predation efficiency (PE) is the ratio of viable prey cells remaining after predation compared to the initial inoculum. I-PR was significantly higher for CF (67%) than for BSI P. aeruginosa isolates (35%) probably related to an environmental origin of CF strains whereas invasive strains are more adapted to humans. I-PR correlation with bacterial features such as mucoid morphotype, genetic background, or antibiotic susceptibility profile was not detected. To test the possibility of increasing I-PR of BSI isolates, a polyhydroxyalkanoate depolymerase deficient B. bacteriovorus bd2637 mutant was used. Global median I-PR and PE values remained constant for both predators, but 31.2% of 109J-resistant isolates were susceptible to the mutant, and 22.9% of 109J-susceptible isolates showed resistance to predation by the mutant, pointing to a predator–prey specificity process. The potential use of predators in the clinical setting should be based on the determination of the I-PR for each species, and the PE of each particular target strain.

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Section: Discussionmentioning

confidence: 99%

Strain-specific predation of Bdellovibrio bacteriovorus on Pseudomonas aeruginosa with a higher range for cystic fibrosis than for bacteremia isolates

Saralegui

Herencias

Halperin

et al. 2022

Sci Rep

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“…Next to biological agents, also environmental and chemical factors can hinder predation by B. bacteriovorus, as reviewed by Mitchell et al (Mitchell et al 2020). These include the soil percentage in an aqueous solution, the osmolality of the medium used and its viscosity.…”

Section: Challenges For Bdellovibrio Survivalmentioning

confidence: 99%

Bdellovibrio bacteriovorus: a potential ‘living antibiotic’ to control bacterial pathogens

Cavallo

Jordana

Glasner

et al. 2021

Critical Reviews in Microbiology

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Bdellovibrio bacteriovorus is a small Deltaproteobacterium which, since its discovery, has distinguished itself for the unique ability to prey on other Gram-negative bacteria. The studies on this particular "predatory bacterium", have gained momentum in response to the rising problem of antibiotic resistance, because it could be applied as a potential probiotic and antibiotic agent. Hereby, we present recent advances in the study of B. bacteriovorus, comprehending fundamental aspects of its biology, obligatory intracellular life cycle, predation resistance, and potential applications. Furthermore, we discuss studies that pave the road towards the use of B. bacteriovorus as a "living antibiotic" in human therapy, focussing on its interaction with biofilms, the host immune response, predation susceptibility and in vivo application models. The available data imply that it will be possible to upgrade this predator bacterium from a predominantly academic interest to an instrument that could confront antibiotic resistant infections.

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Biocontrol treatment: Application of Bdellovibrio bacteriovorus HD100 against burn wound infection caused by Pseudomonas aeroginosa in mice

Tajabadi

Karimian

Mohsenipour

et al. 2023

Burns

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Compounds affecting predation by and viability of predatory bacteria

Cited by 5 publications

References 62 publications

Strain-specific predation of Bdellovibrio bacteriovorus on Pseudomonas aeruginosa with a higher range for cystic fibrosis than for bacteremia isolates

Strain-specific predation of Bdellovibrio bacteriovorus on Pseudomonas aeruginosa with a higher range for cystic fibrosis than for bacteremia isolates

Bdellovibrio bacteriovorus: a potential ‘living antibiotic’ to control bacterial pathogens

Biocontrol treatment: Application of Bdellovibrio bacteriovorus HD100 against burn wound infection caused by Pseudomonas aeroginosa in mice

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