Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes

Bamba, Yoshinori; Yun, Young Sook; Kunugi, Akira; Inoue, Hiroo

doi:10.1007/s11418-011-0507-0

Cited by 44 publications

(27 citation statements)

References 14 publications

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“…A third cause of adverse events is the inappropriate use of dietary supplements including an excessive intake or the concomitant use of various dietary supplements and/or medicines. In the past few decades, a large number of ingredients have been shown to interact with drugs [15–21]; however, it currently remains unclear whether most ingredients in dietary supplements interact with drugs.…”

Section: Introductionmentioning

confidence: 99%

Behaviors of consumers, physicians and pharmacists in response to adverse events associated with dietary supplement use

Chiba

Sato

Kobayashi

et al. 2017

Nutr J

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BackgroundThe prevalence of dietary supplements has increased in Japan, and, as a consequence, the adverse events associated with dietary supplement use have become more prominent. Severe adverse events must be reported to the Japanese government via public health centers. However, the number of cases reported to the Japanese government is limited. To clarify this discrepancy, we conducted an internet questionnaire, and surveyed how consumers, physicians and pharmacists acted when they or their patients developed adverse events due to dietary supplement use.MethodsThis study was completed by 2732 consumers, 515 physicians, and 515 pharmacist via internet surveillance on November 2015.ResultsAlthough 8.8% of consumers developed adverse events including diarrhea, constipation, stomachache, headache, and nausea and vomiting, most of them did not report their adverse events to public health centers. However, some consumers went to hospitals because of adverse events. We also surveyed how physicians and pharmacists acted when their patients developed adverse events due to dietary supplement use. Most physicians and pharmacists did not report these cases to public health centers because they were unable to definitively prove the cause-and-effect relationship of these adverse events. Furthermore, some physicians and pharmacists did not know how or where to report these adverse events.ConclusionsWe clarified the reasons for the limited number of reports of adverse events to the Japanese government in this survey. It is important to encourage not only consumers, but also physicians and pharmacists to report adverse events to public health centers. In addition, an analyzing tool of cause-and-effect relationships might be helpful for physicians and pharmacists.Electronic supplementary materialThe online version of this article (doi:10.1186/s12937-017-0239-4) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Behaviors of consumers, physicians and pharmacists in response to adverse events associated with dietary supplement use

Chiba

Sato

Kobayashi

et al. 2017

Nutr J

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show abstract

“…Physicians and pharmacists need to be aware of which of their patients are concomitantly using dietary supplements and medicines because many herbs (e.g., black cohosh, coleus forskohlii, echinacea, garlic, ginkgo, ginseng, green tea, kava, milk thistle, and St. John's wort) 13–18) and ingredients (e.g., catechins 19) , curcuminoids 20) , isoflavones 21) , quercetin 22) , and polyphenols 23) ) affect drug-metabolizing enzymes. Resveratrol 24) also affects the drug-metabolizing enzyme cytochrome P-450 (CYP).…”

Section: Introductionmentioning

confidence: 99%

<i>Trans</i>-Resveratrol Enhances the Anticoagulant Activity of Warfarin in a Mouse Model

Chiba

Kimura

Suzuki

et al. 2016

J Atheroscler Thromb

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Aim: Resveratrol is a popular ingredient in dietary supplements. Some patients concomitantly use dietary supplements and medicines in Japan. In the present study, we determined whether trans-resveratrol and melinjo (Gnetum gnemon L.) seed extract (MSE), which contains resveratrol dimers, interacted with drugs using a mouse model.Methods: Male C57BL/6J mice were fed experimental diets containing 0.005%, 0.05%, or 0.5% (w/w) trans-resveratrol or MSE for 1 or 12 weeks. The expression of liver cytochrome P-450 (CYP) mRNA and activity of liver microsomal CYP were measured. To determine the influence of resveratrol or MSE on drug efficacy, the anticoagulant activity of warfarin was examined in mice that were fed diets containing trans-resveratrol or MSE for 12 weeks.Results: When the mice were fed experimental diets for 1 week, none of the doses of trans-resveratrol and MSE affected body weight, liver weight, or plasma AST and ALT levels. Trans-resveratrol also did not affect CYP1A1, CYP1A2, CYP2C, or CYP3A activities. In contrast, 0.5% MSE slightly increased CYP1A1 activity. When the mice were fed experimental diets for 12 weeks, 0.05% trans-resveratrol increased CYP1A1, CYP2C, and CYP3A activities, whereas 0.5% MSE suppressed CYP3A activity. Under these conditions, 0.5% trans-resveratrol enhanced the anticoagulant activity of warfarin, although CYP2C activity increased. However, MSE did not affect the anticoagulant activity of warfarin.Conclusion: The 0.05% trans-resveratrol did not interact with warfarin in a mouse model, whereas 0.5% trans-resveratrol may have enhanced the anticoagulant activity of warfarin.

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“…The rhizome of Curcuma aromatica Salisb. is widely used as a traditional herbal medicine for anti-tumor therapy in China, Japan and other Asian countries (5). Findings of recent studies have demonstrated that germacrone, a major bioactive component of Curcuma aromatica Salisb., possesses anti-tumor, anti-inflammatory and neuroprotective properties.…”

Section: Introductionmentioning

confidence: 99%

Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest

Liu

Gao

Wang

et al. 2014

Molecular Medicine Reports

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Germacrone is one of the major bioactive components of the traditional Chinese Medicinal plant Curcuma aromatica Salisb. and has been shown to possess anti‑tumor properties. In the present study, the anti‑proliferative effect of germacrone on human glioma cells and the molecular mechanism underlying its cytotoxicity were investigated. Treatment of the U87 and U251 human glioma cell lines with germacrone inhibited the cell proliferation in a dose‑ and time‑dependent manner as assessed by MTT assay, while significantly lower effects were observed on normal human astrocytes. Flow cytometric analysis and DNA fragmentation revealed that germacrone promoted apoptosis of glioma cells, associated with an increased expression of p53 and bax and decreased expression of bcl‑2. Furthermore, flow cytometric cell cycle analysis revealed that germacrone induced G1 phase arrest, associated with an obvious decrease in the expression of cyclin D1 and CDK2 and an increased expression of p21. In conclusion, the present study suggested that germacrone may be a novel potent chemopreventive drug candidate for gliomas via regulating the expression of proteins associated with apoptosis and G1 cell cycle arrest.

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Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes

Cited by 44 publications

References 14 publications

Behaviors of consumers, physicians and pharmacists in response to adverse events associated with dietary supplement use

Behaviors of consumers, physicians and pharmacists in response to adverse events associated with dietary supplement use

<i>Trans</i>-Resveratrol Enhances the Anticoagulant Activity of Warfarin in a Mouse Model

Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest

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