Comprehensive analysis of aberrantly expressed profiles of lncRNAs, miRNAs and mRNAs with associated ceRNA network in cholangiocarcinoma

Wang, Xiang; Hu, Kai; Zhang, You Qian; Yang, Chun; Yao, Han

doi:10.3233/cbm-181684

Cited by 28 publications

(27 citation statements)

References 29 publications

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“…Recent meta-analyses of The Cancer Genome Atlas (TCGA) database identified differentially expressed lncRNA in CCA (e.g. LINC00313, NEXN-AS1, COL18A1-AS1, HULC), the expression of some of them being significantly associated with overall survival (OS) of patients 8,9 . Mechanistically, co-expression network analysis of coding and non-coding RNA in resected CCA tumors identified lncRNA (e.g.…”

Section: Introductionmentioning

confidence: 99%

Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma

Angenard

Merdrignac

Louis

et al. 2019

Digestive and Liver Disease

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Background: Intrahepatic cholangiocarcinoma (iCCA) is a deadly cancer worldwide associated with an increased incidence, limited therapeutic options and absence of reliable prognostic biomarkers. Long non-coding RNAs (lncRNA) emerge as relevant biomarkers in cancer being associated with tumor progression. However, lncRNA have been poorly investigated in iCCA. Aim: To identify lncRNA significantly associated with the survival of patients with iCCA after tumor resection for curative intent. Methods: Gene expression profiling and Q-RT-PCR were performed from a cohort of 39 clinically well-annotated iCCA. Univariate Cox proportional hazards model with Wald Statistic was used to identify lncRNA significantly associated with overall (OS) and/or disease-free (DFS) survival. Results: A signature made of 9 lncRNA was identified to be significantly (P<0.05) associated with OS and DFS, including 4 lncRNA (lnc-CDK9-1, XLOC_l2_009441, CDKN2B-AS1, HOXC13-AS) highly expressed in poor prognosis iCCA and 5 lncRNA (lnc-CCHCR1-1, lnc-AF131215.3.1, lnc-CBLB-5, COL18A1-AS2, lnc-RELL2-1) highly expressed in better prognosis iCCA. We further validated CDKN2B-AS1 (ANRIL) as a poor prognosis biomarker, not only in iCCA, but also in hepatocellular carcinoma, kidney renal clear cell carcinoma and uterine corpus endometrial carcinoma. Conclusions: We report a prognosis lncRNA signature in iCCA and the clinical relevance of CDKN2B-AS1 (ANRIL) overexpression in several cancers.

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Section: Introductionmentioning

confidence: 99%

Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma

Angenard

Merdrignac

Louis

et al. 2019

Digestive and Liver Disease

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“…For instance, the lncRNA ANRIL can sponge miR-144, which leads to the translation of the miR-144 target PBX3, a speculated PI3K/AKT and JAK/STAT pathway activating protein, which in turn results in enhanced tumorigenesis [46]. In BTC, Wang et al could construct a ceRNA-miRNA-mRNA network, consisting of more than 206 RNA species and 450 interactions, pointing out the complexity and importance of ceRNA-based regulatory networks also in BTC [51].…”

Section: Long Non-coding Rnasmentioning

confidence: 99%

Long Non-Coding RNAs in Biliary Tract Cancer—An Up-to-Date Review

Bekric

Neureiter

Ritter

et al. 2020

JCM

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The term long non-coding RNA (lncRNA) describes non protein-coding transcripts with a length greater than 200 base pairs. The ongoing discovery, characterization and functional categorization of lncRNAs has led to a better understanding of the involvement of lncRNAs in diverse biological and pathological processes including cancer. Aberrant expression of specific lncRNA species was demonstrated in various cancer types and associated with unfavorable clinical characteristics. Recent studies suggest that lncRNAs are also involved in the development and progression of biliary tract cancer, a rare disease with high mortality and limited therapeutic options. In this review, we summarize current findings regarding the manifold roles of lncRNAs in biliary tract cancer and give an overview of the clinical and molecular consequences of aberrant lncRNA expression as well as of underlying regulatory functions of selected lncRNA species in the context of biliary tract cancer.

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“…The top 30 coexpressed mRNAs of each lncRNA were selected to discuss the regulatory relationship between lncRNA and coexpressed mRNA using Cytoscape 3.6.1 (https://cytoscape.org/) [21].…”

Section: Stem Analysis and Coexpressionmentioning

confidence: 99%

The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation

Wang

et al. 2020

BioMed Research International

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Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs that modulate gene expression, thereby participating in the regulation of various cellular processes. However, it is not clear about the expression and underlying mechanism of lncRNAs in irradiation-induced DNA damage response. In the present study, we performed integrative analysis of lncRNA-mRNA expression profile in human lymphocytes irradiated with ultraviolet-C (UVC). The results showed that exposure to UVC irradiation dose-dependently increased the fluorescence intensity of γ-H 2 AX and induced cell death. Microarray analysis revealed that up-regulated lncRNAs were more common than down-regulated lncRNAs with the increase of radiation dose in UVC-radiated cells. Stem analysis demonstrated the relationship between lncRNA expression level and radiation dose. qPCR results confirmed that LOC338799 and its coexpressed genes such as LCE1F and ISCU showed the increase in expression levels with the increase of UVC radiation dose. We utilized Cytoscape to screen out 5 lncRNAs and 13 coexpressed genes linking to p53, which might participate in the regulation of DNA damage, cell cycle arrest, apoptosis, and cell death. These findings suggest that lncRNAs might play a role in UVC-induced DNA damage response through regulating expression of genes in p53 signaling pathway.

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Comprehensive analysis of aberrantly expressed profiles of lncRNAs, miRNAs and mRNAs with associated ceRNA network in cholangiocarcinoma

Cited by 28 publications

References 29 publications

Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma

Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma

Long Non-Coding RNAs in Biliary Tract Cancer—An Up-to-Date Review

The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation

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