Comprehensive analysis of differential circular RNA expression in a mouse model of colitis‐induced colon carcinoma

Yuan, Gang; Chen, Tingjia; Zhang, Haiqing; Cao, Qinghua; Qiu, Yun; Que, Biao; Peng, Sui; Chen, Minhu; Ji, Weidong

doi:10.1002/mc.22900

Cited by 17 publications

(12 citation statements)

References 44 publications

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“…Zeng et al also detected 431 DECs (192 upregulated and 239 downregulated) in CRC tissues from patients with lung metastasis compared with CRC tissues from patients without metastasis using a high-throughput microarray assay [58]. Interestingly, Yuan et al and Chen et al searched for tumorigenesis-and metastasis-associated circRNAs in CRC mouse models using RNA-seq; finally, mmu-circ-001226/mmu-circ-000287 and circ-NSD2 (mm9_circ_003195) were identified to be associated with CRC tumorigenesis and metastasis, respectively [59,60].…”

Section: Dysregulated Circrnas In Crc Tissuesmentioning

confidence: 99%

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

et al. 2021

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Colorectal cancer (CRC) is a common hereditary tumor that is often fatal. Its pathogenesis involves multiple genes, including circular RNAs (circRNAs). Notably, circRNAs constitute a new class of noncoding RNAs (ncRNAs) with a covalently closed loop structure and have been characterized as stable, conserved molecules that are abundantly expressed in tissue/development-specific patterns in eukaryotes. Based on accumulating evidence, circRNAs are aberrantly expressed in CRC tissues, cells, exosomes, and blood from patients with CRC. Moreover, numerous circRNAs have been identified as either oncogenes or tumor suppressors that mediate tumorigenesis, metastasis and chemoradiation resistance in CRC. Although the regulatory mechanisms of circRNA biogenesis and functions remain fairly elusive, interesting results have been obtained in studies investigating CRC. In particular, the expression of circRNAs in CRC is comprehensively modulated by multiple factors, such as splicing factors, transcription factors, specific enzymes and cis-acting elements. More importantly, circRNAs exert pivotal effects on CRC through various mechanisms, including acting as miRNA sponges or decoys, interacting with RNA binding proteins, and even translating functional peptides. Finally, circRNAs may serve as promising diagnostic and prognostic biomarkers and potential therapeutic targets in the clinical practice of CRC. In this review, we discuss the dysregulation, functions and clinical significance of circRNAs in CRC and further discuss the molecular mechanisms by which circRNAs exert their functions and how their expression is regulated. Based on this review, we hope to reveal the functions of circRNAs in the initiation and progression of cancer and highlight the future perspectives on strategies targeting circRNAs in cancer research.

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Section: Dysregulated Circrnas In Crc Tissuesmentioning

confidence: 99%

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

et al. 2021

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“…More recently, there have been a growing number of publications focusing on the roles of circRNAs in the pathogenesis of malignancies, such as hepatocellular carcinoma (HCC) [3], gastric cancer [4], non-small-cell lung cancer (NSCLC) [5] and breast cancer [6]. Particularly, with the development of high-throughput sequencing technology and microarray assay, numerous differentially expressed circRNAs are identified in tumor tissues [7,8], while the underlying molecular mechanisms of circRNAs in the carcinogenesis of malignant tumor need yet to be uncovered.…”

Section: Introductionmentioning

confidence: 99%

Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway

et al. 2019

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Background: Circular RNAs (circRNAs) have been reported as the competing endogenous RNAs (ceRNAs) to sponge microRNAs (miRNAs) implicating in the initiation and progression of breast cancer. However, the functions of circRNAs in breast cancer have not been completely clarified. In the present study, we aimed to identify differentially expressed circRNAs in breast cancer tumor tissues, and their roles and downstream targets were investigated in the progression of breast cancer. Methods: High-throughput circRNA sequencing was performed to detect the differentially expressed circRNAs. The CCK-8 and flow cytometry were performed to measure the cell viability and apoptosis in breast cancer cells. Gene and protein expression were assayed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blotting, respectively. Results: hsa_circ_0004771 and Zinc finger E-box binding homeobox 2 (ZEB2) expression levels were up-regulated and positively correlated in breast cancer tumor tissues. In addition, the expression levels of miR-653 were reduced in breast cancer tumor tissues. We also found that hsa_circ_0004771 functioned as a sponge of miR-653 to inhibit its expression. miR-653 as a post-transcriptional regulator down-regulated the expression of ZEB2 by binding to its 3′-UTR. Interestingly, a significant inverse correlation was observed between miR-653 and hsa_circ_0004771 or ZEB2 expression in breast cancer tumor tissues. Knockdown of hsa_circ_0004771 and ZEB2 served as equally authentic of miR-653 mimics to induce growth inhibition and apoptosis in breast cancer cells. Conclusion: Hsa_circ_0004771/miR-653/ZEB2 regulatory feedback revealed a new molecular mechanism in the pathogenesis of breast cancer, which might provide novel therapeutic targets for the treatment of breast cancer.

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“…Moreover, this study explored the possible connections between circRNAs and miRNAs and attempted to establish a network. It was found that mmu_ circRNA_001226 and mmu_circRNA_000287 were the first two key points in this network 148 . The mmucirc-001226/mmu-circ-000287-miRNA-mRNA network may be the potential mechanism for CAC 148 .…”

Section: Circrnas In Cacmentioning

confidence: 90%

“…Yuan et al 148 reported that altered expression profiles of circRNAs are involved in CAC development. Compared with in normal colonic tissues, mmu_circRNA_001801, mmu_circRNA_002987, and mmu_circRNA_001155 were the most increased circRNAs, and mmu_circRNA_00287, mmu_circRNA_003037, and mmu_circRNA_001226 were the most decreased circRNAs 148 . Moreover, this study explored the possible connections between circRNAs and miRNAs and attempted to establish a network.…”

Section: Circrnas In Cacmentioning

confidence: 99%

Which long noncoding RNAs and circular RNAs contribute to inflammatory bowel disease?

et al. 2020

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Inflammatory bowel disease (IBD), a chronic relapsing gastrointestinal inflammatory disease, mainly comprises ulcerative colitis (UC) and Crohn's disease (CD). Although the mechanisms and pathways of IBD have been widely examined in recent decades, its exact pathogenesis remains unclear. Studies have focused on the discovery of new therapeutic targets and application of precision medicine. Recently, a strong connection between IBD and noncoding RNAs (ncRNAs) has been reported. ncRNAs include microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). The contributions of lncRNAs and circRNAs in IBD are less well-studied compared with those of miRNAs. However, lncRNAs and circRNAs are likely to drive personalized therapy for IBD. They will enable accurate diagnosis, prognosis, and prediction of therapeutic responses and promote IBD therapy. Herein, we briefly describe the molecular functions of lncRNAs and circRNAs and provide an overview of the current knowledge of the altered expression profiles of lncRNAs and circRNAs in patients with IBD. Further, we discuss how these RNAs are involved in the nosogenesis of IBD and are emerging as biomarkers. Facts • long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are involved in the pathogenesis of inflammatory bowel disease (IBD). • Moreover, certain lncRNAs and circRNAs are potential biomarkers of IBD. • The contributions of lncRNAs and circRNAs in IBD will become hot spots in future studies. Open questions • lncRNAs and circRNAs show altered expression profile in patients with IBD compared with those in healthy controls. • Which and how are lncRNAs and circRNAs involved in the internal mechanism of IBD? • Will lncRNAs and circRNAs serve as clinical biomarkers of IBD?

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Comprehensive analysis of differential circular RNA expression in a mouse model of colitis‐induced colon carcinoma

Cited by 17 publications

References 44 publications

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway

Which long noncoding RNAs and circular RNAs contribute to inflammatory bowel disease?

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