Comprehensive analysis of HHV‐6 and HHV‐7‐related gene signature in prognosis and response to temozolomide of glioma

Chen, Luoyi; Zhao, Xinchen; Liu, Yuyang; Wu, Mengwan; Li, Shurong; Xu, Chuan; Shi, Ying

doi:10.1002/jmv.28285

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…There is no standard treatment for HHV-7 viral encephalitis or meningitis; treatment can last from weeks to months[ 20 ]. Laboratory examination, imaging, cerebrospinal fluid mNGS, and other technologies are used to achieve accurate diagnosis, and neurobiology and other research methods are applied to explore the pathogenesis of diseases and treatment targets[ 21 - 23 ]. The clinical manifestations and prognosis of patients with HHV-7 infection in the central nervous system vary greatly from individual to individual.…”

Section: Discussionmentioning

confidence: 99%

Human herpesvirus 7 meningitis in an adolescent with normal immune function: A case report

Zhen,

Yang,

Liao

2024

World J Clin Cases

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BACKGROUND Human herpesvirus type 7 (HHV-7) is a less common herpes virus that usually causes mild, self-limiting illnesses. However, in recent years, there have been increasing reports of HHV-7 causing serious central nervous system infections, especially meningitis. The pathogenesis and clinical features of HHV-7 meningitis, particularly in adolescents with normal immune function, remain incompletely studied. Therefore, the purpose of this report is to share a case of HHV-7 meningitis in an immunocompetent adolescent with a view to deepening our understanding of the disease. CASE SUMMARY A 12-year-old female was admitted with fever, headache, and vomiting. 4 d before admission, the patient developed a fever without obvious induction, with a temperature up to 39.5 °C, no convulsions, accompanied by chills, headaches, fatigue, and no muscle aches. The patient was treated with fever reduction, which could be reduced to 38 °C; repeated high fever, accompanied by vomiting 7-8 times; and no abdominal pain or diarrhea. The patient was diagnosed with "acute suppurative tonsillitis" in a local hospital, and the blood routine was generally normal. The patient was given symptomatic support treatment such as "ceftriaxone sodium" and antiemetic rehydration for 2 d, and his condition did not improve. The patient's physical examination showed pharyngeal congestion, bilateral tonsil grade I hypertrophy, regression of purulent secretions, and cervical resistance. Ocular B-ultrasound: Opacity of the vitreous body and edema of the optic disc in both eyes. Optical coherence tomography examination showed that the macular fovea was generally normal in both eyes, with edema of the optic disc. DNA virus monitoring results: HHV-7. We gave ganciclovir antiviral therapy, dexamethasone anti-inflammatory treatment, mannitol to reduce cranial pressure, omeprazole to protect gastrointestinal mucosa, and calcium and potassium supplementation. CONCLUSION This study reports a case of HHV-7 meningitis in an adolescent with normal immune function. Through comprehensive analysis of the clinical manifestations, laboratory tests, and treatment methods of the patient, it is found that early identification and antiviral treatment are essential for the outcome of the disease. This case suggests that despite normal immune function, adolescents may still suffer from herpes virus type 7 meningitis, so clinicians should be vigilant and take effective treatment measures in time.

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Section: Discussionmentioning

confidence: 99%

Human herpesvirus 7 meningitis in an adolescent with normal immune function: A case report

Zhen,

Yang,

Liao

2024

World J Clin Cases

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Comprehensive analysis of HHV‐6 and HHV‐7‐related gene signature in prognosis and response to temozolomide of glioma

Chen

Zhao

Liu

et al. 2022

Journal of Medical Virology

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Human herpesvirus (HHV)‐6 and HHV‐7 have been detected in central nervous system and glioma tissue, while their exact role in glioma remains uncertain. Omics profiles and clinical information were downloaded from public databases, including The Cancer Genome Atlas cohort for training set and the Chinese Glioma Genome Atlas cohorts for validation sets. Differentially expressed genes between HHV‐6 and HHV‐7 infected or noninfected glioma patients were screened for establishing the HHV‐6 and HHV‐7 infection (HI) model through Lasso regression analysis. Bioinformatics methods were used to analyze the correlation between HI scores and prognosis, metastasis in glioma patients. Predictable efficacy of HI in temozolomide‐resistance and HI‐related genetic signatures were also explored. The HI model was constructed as: Risk score = (0.014709*DIRAS3) + (0.029787*TEX26) + (0.223492*FBXO39) + (0.074951*MYBL1) + (0.060202*HILS1). The five gene signature showed good performance in predicting survival time for glioma patients, while higher HI score is correlated with malignant features. Moreover, DNA mismatch repair genes were augmented in glioma patients with higher HI score as well as nonresponse to temozolomide treatment, which was in parallel with the transcriptomic result of temozolomide‐resistant glioma cell. Targeting the five gene signature is beneficial for prognosis of glioma patients, especially in glioma patients underwent temozolomide treatment.

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Comprehensive analysis of HHV‐6 and HHV‐7‐related gene signature in prognosis and response to temozolomide of glioma

Cited by 2 publications

References 35 publications

Human herpesvirus 7 meningitis in an adolescent with normal immune function: A case report

Human herpesvirus 7 meningitis in an adolescent with normal immune function: A case report

Comprehensive analysis of HHV‐6 and HHV‐7‐related gene signature in prognosis and response to temozolomide of glioma

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