Objective: To detect the role of long non-coding RNA (lncRNA) CROCC Pseudogene 2 (CROCCP2)/miR-5584-5p /Baculoviral IAP Repeat Containing 5 (BIRC5) network in glioma growth. Methods: The Cancer Genome Atlas (TCGA) database was accessed to obtain the gene datasets associated with glioma growth. Bioinformatics techniques was employed to analyze the key network and construct the regulatory network of lncRNA CROCCP2/miR-5584-5p targeting BIRC5. Subsequently, the quantitative Polymerase Chain Reaction (qPCR) experiment was conducted to validate the expression levels of LncRNA CROCCP2, miR-5584-5p, and BIRC5 in both glioma tissues and normal brain tissues. Furthermore, we harnessed RNA interference technology to knock down BIRC5 in U251 cells, and flow cytometry was utilized to assess cell apoptosis. Results: LncRNA CROCCP2 is implicated in the binding of miR-5584-5p, and targeting BIRC5. PCR analysis revealed an elevated expression level of CROCCP2 and BIRC5 in glioma tissues, accompanied by a low expression of miR-5584-5p. Moreover, knockdown of BIRC5 results in an induction of apoptosis. Conclusions: LncRNA CROCCP2 could absorb miR-5584-5p targeting BIRC5 to activate cell apoptosis, so as to inhibit glioma development.