Comprehensive Analysis of the Effect of Probiotic Intake by the Mother on Human Breast Milk and Infant Fecal Microbiota

Shin, Do Young; Park, Jongsun; Yi, Dae Yong

doi:10.3346/jkms.2021.36.e58

Cited by 7 publications

(3 citation statements)

References 49 publications

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“…This core bacteriome included nine genera: Staphylococcus , Streptococcus , Serratia , Pseudomonas , Corynebacterium , Ralstonia , Propionibacterium , Sphingomonas , and Bradyrhizobium [ 42 ]. However, these results were inconsistent with subsequent studies [ 43 , 48 , 49 , 50 ]. One study identified a core bacteriome of 12 genera: Staphylococcus , Streptococcus , Bifidobacterium , Balutia , Brevundimonas , Corynebacterium , Flavobacterium , Propionibacterium , Pseudomonas , Ralstonia , Rothia , and Burkholderia [ 43 ].…”

Section: The Hbm-derived Microbiomecontrasting

confidence: 82%

Human Breast Milk Composition and Function in Human Health: From Nutritional Components to Microbiome and MicroRNAs

Kim

2021

Nutrients

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107

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Human breast milk (HBM) is not only an indispensable source of nutrients for early human growth and development, supplying components that support infant growth and development, but also contains various essential immunologic components with anti-infectious activities and critical roles in the formation of immunity. It is also known that HBM contains its own unique microbiome, including beneficial, commensal, and potentially probiotic bacteria, that can contribute to infant gut colonization. In addition, HBM-derived extracellular vesicles, exosomes, and microRNA are attracting increasing interest for their potential to transfer to the infant and their role in infant development. In this article, we examine some of the various constituents in HBM and review the evidence supporting their associated health effects and their potential applications in human health.

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Section: The Hbm-derived Microbiomecontrasting

confidence: 82%

Human Breast Milk Composition and Function in Human Health: From Nutritional Components to Microbiome and MicroRNAs

Kim

2021

Nutrients

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107

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“…Within Firmicutes , rectal swab levels for microbes from genera Fournierella and Marvinbryantia were weakly positively correlated with level of those genera in mare’s milk. Studies have found these genera in milk from humans and rats [ 31 , 32 ]. Thus, for the most part, changes within Firmicutes seemed to be better correlated with aging than with milk or lysozyme activity.…”

Section: Discussionmentioning

confidence: 99%

Comparing microbiotas of foals and their mares’ milk in the first two weeks after birth

Mienaltowski,

Callahan,

De La Torre

et al. 2024

BMC Vet Res

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Background The mare-foal relationship is essential for the well-being and growth of a foal. Mare’s milk provides a foal with nutrients, protective immunity, and microbes. Within the first two weeks of life, there is a risk for a foal to suffer from diarrhea, particularly “foal heat diarrhea” which happens at about the time of a mare’s estrus cycle but is more likely due to transitions in the microbiota in the foal’s gastrointestinal (GI) tract. We hypothesized that this GI microbiota transition could be caused by changes in lysozyme and microbial populations in the mare’s milk. To test this hypothesis, fifteen mare-foal pairs were followed in the first 15 days post-foaling. Every other day milk was collected from mares and rectal swabs were collected from foals. Lysozyme activity in the mare’s milk was measured using a fluorescence assay. Microbial DNA was isolated from the milk and swabs and the V4 domain of 16 S rRNA genes were PCR amplified and sequenced using Illumina MiSeq technology. Microbial populations were analyzed using DADA2 and phyloseq within R. Results Mare’s milk lysozyme activity peaked for samples at Day 1 and levels dropped to 72.5% of Day 1 activity by Day 15; however, microbial populations in the mare’s milk did not vary significantly over the two weeks. Furthermore, levels of microbial diversity found in foal rectal swabs were initially similar to microbial diversity seen in mare’s milk; however, over the first fifteen days, diversity increased for the foal rectal swab microbiota and swab microbial populations differed from milk microbes. A transition occurred shifting from microbes from the phylum Proteobacteria early in rectal swabs to those primarily from the phyla Firmicutes and Bacteroidota after the first few days post-foaling. These phyla contained several families and genera of microbes that promote utilization of milk components in healthy gut transition. Microbial abundance levels correlated more with days post-parturition than with lysozyme activity and mare’s milk microbial populations. Conclusions The findings suggest that much of the microbial populations responsible for the transition of the foal’s gut comes from sources outside of mare’s milk species and levels of lysozyme activity.

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“…Maternal vaginal, skin, oral, gut, uterus, and breast milk communities were reported to contribute to early life microbiota ( Collado et al, 2016 ; Ferretti et al, 2018 ; Differding and Mueller, 2020 ). Moreover, probiotics may influence the communities of breast milk and the vagina ( Liang et al, 2021 ; Shin et al, 2021 ). In this study, it was confirmed that probiotic intake could alter maternal gut microbial network and interactions.…”

Section: Discussionmentioning

confidence: 99%

Probiotic supplementation during pregnancy alters gut microbial networks of pregnant women and infants

Huang

Tye

et al. 2022

Front. Microbiol.

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BackgroundProbiotic supplementation has been popular and widespread, yet we still lack a comprehensive understanding of how probiotic supplementation during pregnancy affects the gut microbial networks of pregnant women and infants. In this study, we firstly used network analysis to compare the gut microbiota of pregnant women with and without probiotic supplementation, as well as their infants.MethodsThirty-one pairs of healthy pregnant women and infants were recruited and randomly divided into the probiotic group (15 mother-infant pairs) and the control group (16 mother-infant pairs). Pregnant women in the probiotic group consumed combined probiotics from 32 weeks to delivery. Fecal samples were collected from pregnant women and infants at several time points. Gut microbiota was evaluated using 16S rRNA gene sequencing. Intestinal microbial network and topological properties were performed using the molecular ecological network analysis.ResultsNo significant difference was found between the probiotic and control groups on the microbial alpha and beta diversity. As the gestational age increased, the total links, average degree, average clustering coefficient, robustness, and the proportion of positive correlations were increased in pregnant women with probiotics administration. In contrast, these indices were decreased in infants in the probiotic group.ConclusionProbiotic supplement does not change the microbial diversity of pregnant women and infants, but significantly alters the intestinal microbial network structure and properties. Although pregnant women have more complicated and stable networks after probiotic administration, their infants have less stable networks.

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Comprehensive Analysis of the Effect of Probiotic Intake by the Mother on Human Breast Milk and Infant Fecal Microbiota

Cited by 7 publications

References 49 publications

Human Breast Milk Composition and Function in Human Health: From Nutritional Components to Microbiome and MicroRNAs

Human Breast Milk Composition and Function in Human Health: From Nutritional Components to Microbiome and MicroRNAs

Comparing microbiotas of foals and their mares’ milk in the first two weeks after birth

Probiotic supplementation during pregnancy alters gut microbial networks of pregnant women and infants

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