Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer

Diao, Bowen; Yang, Ping

doi:10.3389/pore.2021.1609855

Cited by 21 publications

(24 citation statements)

References 45 publications

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“…We could observe increased expression of LAMB3 in PAC-resistant cell lines. Overexpression of LAMB3 was also observed in platinum-resistant ovarian cancer patients [ 72 ], suggesting this gene’s role in drug resistance. In our study, increased expression of LAMB3 correlated with decreased expression of miR-218-5p.…”

Section: Discussionmentioning

confidence: 99%

The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Cisplatin- and Paclitaxel-Resistant Ovarian Cancer Cell Lines

Kaźmierczak

Jopek

Sterzyńska

et al. 2022

IJMS

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Ovarian cancer is the most lethal gynecological malignancy. The high mortality results from late diagnosis and the development of drug resistance. Drug resistance results from changes in the expression of different drug-resistance genes that may be regulated miRNA. The main aim of our study was to detect changes in miRNA expression levels in two cisplatin (CIS) and two paclitaxel (PAC)—resistant variants of the A2780 drug-sensitive ovarian cancer cell line—by miRNA microarray. The next goal was to identify miRNAs responsible for the regulation of drug-resistance genes. We observed changes in the expression of 46 miRNA that may be related to drug resistance. The overexpression of miR-125b-5p, miR-99a-5p, miR-296-3p, and miR-887-3p and downregulation of miR-218-5p, miR-221-3p, and miR-222-3p was observed in both CIS-resistant cell lines. In both PAC-resistant cell lines, we observed the upregulation of miR-221-3p, miR-222-3p, and miR-4485, and decreased expression of miR-551b-3p, miR-551b-5p, and miR-218-5p. Analysis of targets suggest that expression of important drug-resistant genes like protein Tyrosine Phosphatase Receptor Type K (PTPRK), receptor tyrosine kinase—EPHA7, Semaphorin 3A (SEMA3A), or the ATP-binding cassette subfamily B member 1 gene (ABCB1) can be regulated by miRNA.

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Section: Discussionmentioning

confidence: 99%

The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Cisplatin- and Paclitaxel-Resistant Ovarian Cancer Cell Lines

Kaźmierczak

Jopek

Sterzyńska

et al. 2022

IJMS

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“…A recent study pointed out the higher mRNA expressions of LAMC2, LAMB3 and LAMA5 were observed in OV tissue compared with normal ovary. LAMC1 and LAMA5 might be prognostic factors and serve as important tumor oncogenes in OV [ 22 ]. LAMA3 was also proved to be an unfavorable prognosis biomarker in OV from another study [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…LAMA3 was also proved to be an unfavorable prognosis biomarker in OV from another study [ 23 ]. Moreover, LAMA1/A5 and LAMC1 were significant negatively correlated with tumor immune infiltrates in OV, especially with dendritic cells, CD8+ T cells or neutrophil [ 22 ]. ITGA3 and ITGB4, belonging to integrin, might synergistically or independently regulate cell adhesion and proliferation in OV and play an important role in the prediction of prognostic for advanced OV patients [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic implications of PPL expression in ovarian cancer

et al. 2022

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Periplakin (PPL) is a main member in plakin family, which plays important role in cellular adhesion complexes supporting and cytoskeletal integrity supplying. PPL was reported to be a potential biomarker candidate for several types of cancers. However, the biological functions and underlying mechanisms of PPL in ovarian cancer (OV) remain unclear. In the present study, we used GEPIA 2, Human Protein Atlas, Oncomine, LinkedOmics, Kaplan–Meier Plotter, STRING, CytoHubba plug-in and TIMER to determine the associations among PPL expression, prognosis, and immune cell infiltration in OV. RT-qPCR and IHC analysis were conducted to validated the role of PPL in an independent OV cohort. Compared with the normal ovary tissues, the levels of PPL mRNA and protein expression were both obviously higher in OV tumors from multiple datasets (P < 0.05), and a poor survival was observed to be strongly correlated with high PPL expression (P < 0.05). Moreover, the results were further validated by RT-qPCR and IHC analysis in an independent OV cohort. A gene-clinical nomogram was constructed, including PPL mRNA expression and clinical factors in TCGA. Functional network analysis suggested that PPL participates in the important pathways like Wnt signaling pathway, MAPK signaling pathway. Ten hub genes (LAMC2, PXN, LAMA3, LAMB3, LAMA5, ITGA3, TLN1, ACTN4, ACTN1, and ITGB4) were identified to be positively associated with PPL. Furthermore, PPL expression was negatively correlated with infiltrating levels of CD4+ T cell, macrophages, neutrophils, and dendritic cells. In conclusion, PPL may be an unfavorable prognostic biomarker candidate in OV, which was also correlated with immune infiltrating and function in immunotherapy response.

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“…In colorectal cancer, LAMA5 overexpression is associated with hepatic metastasis, angiogenesis, and NOTCH1 pathway inhibition [ 47 ]. In ovarian cancer, LAMA5 overexpression was associated with a good prognosis [ 48 ]. No information about the potential use of LAMA5 as a biomarker for prognosis in gastric cancer has been reported.…”

Section: Discussionmentioning

confidence: 99%

Somatic Mutational Landscape in Mexican Patients: CDH1 Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma

Cerrato-Izaguirre

Chirino

Prada

et al. 2022

IJMS

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The Hispanic population, compared with other ethnic groups, presents a more aggressive gastric cancer phenotype with higher frequency of diffuse-type gastric adenocarcinoma (GA); this could be related to the mutational landscape of GA in these patients. Using whole-exome sequencing, we sought to present the mutational landscape of GA from 50 Mexican patients who were treated at The Instituto Nacional de Cancerología from 2019 to 2020. We performed a comprehensive statistical analysis to explore the relationship of the genomic variants and clinical data such as tumor histology and presence of signet-ring cell, H. pylori, and EBV. We describe a potentially different mutational landscape between diffuse and intestinal GA in Mexican patients. Patients with intestinal-type GA tended to present a higher frequency of NOTCH1 mutations, copy number gains in cytobands 13.14, 10q23.33, and 12q25.1, and copy number losses in cytobands 7p12, 14q24.2, and 11q13.1; whereas patients with diffuse-type GA tended to present a high frequency of CDH1 mutations and CNV gains in cytobands 20q13.33 and 22q11.21. This is the first description of a mutational landscape of GA in Mexican patients to better understand tumorigenesis in Hispanic patients and lay the groundwork for discovering potential biomarkers and therapeutic targets.

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Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer

Cited by 21 publications

References 45 publications

The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Cisplatin- and Paclitaxel-Resistant Ovarian Cancer Cell Lines

The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Cisplatin- and Paclitaxel-Resistant Ovarian Cancer Cell Lines

Prognostic implications of PPL expression in ovarian cancer

Somatic Mutational Landscape in Mexican Patients: CDH1 Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma

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