Comprehensive analysis of the volume of bone for grafting that can be harvested from iliac crest donor sites

Kılınç, Adnan; Korkmaz, İsmail Hakkı; Kaymaz, İrfan; Kilinc, Z.; Dayı, Ertunç; Kantarcı, Abdulmecit

doi:10.1016/j.bjoms.2017.07.011

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…However, there are also limitations, like donor site morbidity, due to an additional operation to obtain iliac crest bone grafts (ICBG), which could even result in the patient needing a wheelchair for up to six months. Last but not least, the amount of obtainable material is limited [ 3 , 4 , 5 ]. To overcome these restrictions, new graft sources that accumulate as waste products during surgery have been investigated for autologous bone grafting.…”

Section: Introductionmentioning

confidence: 99%

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Ottensmeyer

Witzler

Schulze

et al. 2018

IJMS

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The need for bone grafts is high, due to age-related diseases, such as tumor resections, but also accidents, risky sports, and military conflicts. The gold standard for bone grafting is the use of autografts from the iliac crest, but the limited amount of accessible material demands new sources of bone replacement. The use of mesenchymal stem cells or their descendant cells, namely osteoblast, the bone-building cells and endothelial cells for angiogenesis, combined with artificial scaffolds, is a new approach. Mesenchymal stem cells (MSCs) can be obtained from the patient themselves, or from donors, as they barely cause an immune response in the recipient. However, MSCs never fully differentiate in vitro which might lead to unwanted effects in vivo. Interestingly, purinergic receptors can positively influence the differentiation of both osteoblasts and endothelial cells, using specific artificial ligands. An overview is given on purinergic receptor signaling in the most-needed cell types involved in bone metabolism—namely osteoblasts, osteoclasts, and endothelial cells. Furthermore, different types of scaffolds and their production methods will be elucidated. Finally, recent patents on scaffold materials, as wells as purinergic receptor-influencing molecules which might impact bone grafting, are discussed.

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Section: Introductionmentioning

confidence: 99%

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Ottensmeyer

Witzler

Schulze

et al. 2018

IJMS

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“…• It is more convenient to harvest bone graft from the anterior iliac crest because most procedures in the lower limb are performed with the patient supine. However, the posterior iliac crest has more cancellous bone and is a better option when large amounts of graft are needed 13,14 . Day 150 after the injury.…”

Section: Contraindicationsmentioning

confidence: 99%

Induced-Membrane Technique in the Management of Posttraumatic Bone Defects

Azi

Teixeira

Cotias

et al. 2019

JBJS Essential Surgical Techniques

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Background: Critical-size bone defects are defined as bone defects where spontaneous regeneration is not expected without treatment 1. The characteristics of bone defects (etiology, location, size, presence of infection, and softtissue conditions) vary greatly and, to be effective, the treatment method should address this variability. The induced-membrane technique, or Masquelet technique, is a method for treating critical-size bone defects 2,3 of various sizes and anatomic locations. It has been used to treat infected and noninfected bone defects and may be performed with a variety of fixation methods 2,3. Description: The induced-membrane technique is a 2-stage procedure. The first stage consists of debridement followed by insertion of a polymethylmethacrylate (PMMA) spacer in the bone defect. The presence of the PMMA leads to a foreign-body reaction with the development of a thick pseudosynovial membrane that is extremely vascularized and rich in growth factors. The filling of the bone defect with the cement spacer prevents fibrous tissue invasion and allows the development of an optimal vascularized gap for bone-grafting. After 6 to 8 weeks, the membrane around the spacer is carefully opened for the removal of the spacer, which is then replaced by bone graft 2,3 , which can be expanded with allograft or biomaterials. Alternatives: Alternatives include vascularized or nonvascularized autologous bone graft, allograft, bone transport methods, titanium cages, megaprostheses, shortening, and amputation. Rationale: Posttraumatic bone defects frequently are associated with soft-tissue injury and infection that impair the local vascularization and the healing potential. The highly vascularized induced membrane may play a role in restoring the local regenerative capacity. Numerous studies have demonstrated its successful use in the treatment of posttraumatic bone defects in the hand, forearm, humerus, femur, tibia, and foot. The induced-membrane technique is especially advantageous in the treatment of infected bone defects because the presence of the spacer helps in the treatment of the infection by reducing dead space, acting as a local antibiotic carrier, and promoting some degree of bone stability 3-5 .

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“…The iliac crest is the most commonly used extraoral donor site for autogenous bone augmentation and has the advantage of providing large amounts of bone volume. Kilinc et al [20] calculated the volume of cancellous and cortical bones that can be grafted from the iliac crest, and it differed greatly compared to the bone volume that can be harvested from the zygomatic alveolar crest. However, in small-to medium-sized maxillary defects, the zygomatic alveolar crest provides sufficient bone for transplantation.…”

Section: Discussionmentioning

confidence: 99%

Autogenous bone augmentation from the zygomatic alveolar crest: a volumetric retrospective analysis in the maxilla

et al. 2020

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Background Autogenous bone augmentation is the gold standard for the treatment of extended bone defects prior to implantation. Bone augmentation from the zygomatic crest is a valuable option with several advantages, but the current literature for this treatment is scant. The aim of this study was to evaluate the increase in bone volume after locoregional bone augmentation using autogenous bone from the zygomatic alveolar crest as well as the complications and success rate. Results Analysis of the augmented bone volume in seven patients showed a maximum volume gain of 0.97 cm3. An average of 0.54 cm3 of autogenous bone (SD 0.24 cm3; median: 0.54 cm3) was augmented. Implantation following bone augmentation was possible in all cases. Complications occurred in three patients. Conclusion The zygomatic alveolar crest is a valuable donor site for autogenous alveolar onlay grafting in a locoregional area such as the maxillary front. Low donor site morbidity, good access, and its suitable convexity make it a beneficial choice for autogenous bone augmentation.

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Comprehensive analysis of the volume of bone for grafting that can be harvested from iliac crest donor sites

Cited by 12 publications

References 16 publications

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells

Induced-Membrane Technique in the Management of Posttraumatic Bone Defects

Autogenous bone augmentation from the zygomatic alveolar crest: a volumetric retrospective analysis in the maxilla

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