Comprehensive comparative study of eco-friendly Univariate and multivariate methodological approaches on processing multi-component formulation quality

Fayez, Yasmin M.; Michael, Adel M.; Monir, Hany H.; Lotfy, Hayam M.; Nessim, Christine K.

doi:10.1016/j.saa.2020.118816

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…The proposed procedures have been applied successfully on the multi-ingredient veterinary formulation and the good recovery and accuracy make them applicable in QC laboratories without the difficulties of HPLC. As compared to some recently published research articles [17][18][19][20], the proposed work shows better sensitivity for the determination of the three anticoccidial drugs as shown in Tables 3 and 6.…”

Section: Discussionmentioning

confidence: 77%

“…Literature survey revealed many reported methods for the determination of AMP, SQX, and DVD either alone or with other drugs in different matrices such as veterinary formulation, surface water, eggs, chicken muscles, chicken plasma, chicken liver and chicken feed. These methods include HPLC/UV [4][5][6], LC/MS [7][8][9][10][11][12], spectroscopic methods [13][14][15][16][17][18][19][20] and electrochemical method [21]. To the best of our knowledge, the ternary mixture of AMP, SQX, and DVD has not been investigated spectrophotometrically.…”

Section: Introductionmentioning

confidence: 99%

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Universal procedures for spectrophotometric determination of anticoccidial drugs; application to multi-ingredient veterinary formulation and computational investigations for multivariate analysis

et al. 2021

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Simple, accurate, and eco-friendly spectrophotometric procedures were proposed and implemented for simultaneous determination of anticoccidial drugs from three different classes namely, amprolium hydrochloride (AMP), sulfaquinoxaline sodium (SQX) and diaveridine hydrochloride (DVD). Dual wavelength in ratio spectra procedure was proposed where the difference in amplitudes (ΔP) in the ratio spectra at 264 nm and 301.9 nm (ΔP264&301.9 nm) corresponded to AMP with mean percentage recovery 100.00±0.923%, while (ΔP250.9&279 nm) and (ΔP218&243.5 nm) corresponded to SQX and DVD with mean percentage recoveries 99.31±1.083 and 100.64±1.219%, respectively. The dual wavelength in ratio spectra procedure was validated according to the ICH guidelines and accuracy, precision and repeatability were found to be within the acceptable limit. Multivariate chemometric approaches, namely, partial least-squares (PLS-2) and principal component regression (PCR) were also proposed with mean percentage recoveries 99.31±0.769, 98.91±1.192 and 99.04±1.245% for AMP, SQX and DVD, respectively, in PLS-2 and 99.63±1.005, 99.11±1.272 and 98.93±1.338% for AMP, SQX and DVD, respectively, in PCR. These procedures were successfully applied to the multi-ingredient veterinary formulation with mean percentage recoveries 100.75±1.238, 99.29±0.875 and 99.34±0.745% for AMP, SQX and DVD, respectively, in dual wavelength in ratio spectra procedure and 101.03±1.261, 101.48±0.984 and 101.10±1.339% for AMP, SQX and DVD, respectively, in PLS-2 and 100.22±1.204, 101.10±0.546 and 100.91±0.677% for AMP, SQX and DVD, respectively, in PCR.

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Section: Discussionmentioning

confidence: 77%