Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia

Hamano-Hasegawa, Keiko; Morozumi, Miyuki; Nakayama, Eiichi; Chiba, Naoko; Murayama, Somay Yamagata; Takayanagi, Reiko; Iwata, Satoshi; Sunakawa, Keisuke; Ubukata, Kimiko

doi:10.1007/s10156-008-0648-6

Cited by 114 publications

(102 citation statements)

References 44 publications

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“…It has been suggested that respiratory viruses, especially rhinovirus and respiratory syncytial virus (RSV), are associated with IPDs in children that do not attend day-care centers (18). Hasegawa et al have reported that RSV is detected mainly during late summer to winter in cases of pediatric community-acquired pneumonia in Japan (19). The increasing prevalence of pneumococcal colonization we identified in autumn may have been associated with the prevalence of such respiratory infections.…”

Section: Discussionmentioning

confidence: 68%

Prevalence and Risk Factors of Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children in Japan

Ueno¹,

Ishii²,

Tateda³

et al. 2013

Jpn J Infect Dis

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SUMMARY:The findings of this study revealed a 22z prevalence of Streptococcus pneumoniae among healthy children in Japan; the prevalence tended to increase with age. We identified attendance at day-care facilities and the presence of older siblings as the major risk factors associated with pneumococcal carriage. A significant decrease in pneumococcal colonization was observed among children during the summer; however, a seasonal variation was independent of various factors. Our findings suggest that prior immunization with heptavalent pneumococcal conjugate vaccine within the current recommended schedule is required for children exposed to these risk factors.

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Section: Discussionmentioning

confidence: 68%

Prevalence and Risk Factors of Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children in Japan

Ueno¹,

Ishii²,

Tateda³

et al. 2013

Jpn J Infect Dis

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“…Legionella pneumophila was exceedingly rare in children, with only 1 case in 1,765 patients with CAP. 52,56 The overall prevalence in adults was 2.8% (95% CI, 2.1%-3.6%), although in most studies it was between 1% and 3%. Again, there was significant heterogeneity.…”

Section: Resultsmentioning

confidence: 98%

Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis

Marchello

Dale

Thai

et al. 2016

The Annals of Family Medicine

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PURPOSE Community-acquired pneumonia (CAP), acute cough, bronchitis, and lower respiratory tract infections (LRTI) are often caused by infections with viruses or Streptococcus pneumoniae. The prevalence of atypical pathogens Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophila, and Bordetella pertussis among patients with these illnesses in the ambulatory setting has not been previously summarized. We set out to derive prevalence information from the existing literature. METHODSWe performed a systematic review of MEDLINE for prospective, consecutive-series studies reporting the prevalence of M pneumoniae, C pneumoniae, L pneumophila and/or B pertussis in outpatients with cough, acute bronchitis, LRTI, or CAP. Articles were independently reviewed by 2 authors for inclusion and abstraction of data; discrepancies were resolved by consensus discussion. A meta-analysis was performed on each pathogen to calculate the pooled prevalence estimates using a random effects model of raw proportions.RESULTS Fifty studies met our inclusion criteria. While calculated heterogeneity was high, most studies reported prevalence for each pathogen within a fairly narrow range. In patients with CAP, the overall prevalences of M pneumoniae and C pneumoniae were 10.1% (95% CI, 7.1%-13.1%) and 3.5% (95% CI, 2.2%-4.9%), respectively. Consistent with previous reports, M pneumoniae prevalence peaked in roughly 6-year intervals. Overall prevalence of L pneumophila was 2.7% (95% CI, 2.0%-3.4%), but the organism was rare in children, with only 1 case in 1,765. In patients with prolonged cough in primary care, the prevalence of B pertussis was 12.4% (95% CI, 4.9%-19.8%), although it was higher in studies that included only children (17.6%; 95% CI, 3.4%-31.8%).CONCLUSIONS Atypical bacterial pathogens are relatively common causes of lower respiratory diseases, including cough, bronchitis, and CAP. Where surveillance data were available, we found higher prevalences in studies where all patients are tested for these pathogens. It is likely that these conditions are underreported, underdiagnosed, and undertreated in current clinical practice.

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“…Though the therapeutic implications of interactions between bacteria and platelets are still being explored, some specialists think that the antibacterial potential of platelets could be utilized by selectively releasing, or mimicking, thrombocidins which are microbicidal proteins found in the human blood platelets [15] .…”

Section: Discussionmentioning

confidence: 99%

Association of Mycoplasma pneumoniae antibody titer level with clinical severity of pneumonia in children

et al. 2017

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The objectives is to establish a positive correlation between the serology titer of Mycoplasma pneumoniae and the severity of pneumonia, with an emphasis on severity of disease presentation between two different age groups. The research included 110 children admitted at the Tianjin Medical University General Hospital, Tianjin, China, from May 2010 to October 2010. This study included disease history, clinical examination findings, laboratory investigations including Mycoplasma pneumoniae antibody titer (MP-IgM) level as well as imaging, and duration of in-patient treatment. The results of the parameters were also compared between two age groups: children <5 years old and ≥5 years old. Seventy-six percent of the patients who had severe presentation of the disease had a high titer of MP-IgM and 63% of them were older than five years. Platelet level seems to be a promising indicator of progression of disease. Leukocytosis was present in only 4.5% of the 110 children. The C-reactive protein was significantly raised in those older than five years of age. A significant correlation has been found between the severity of disease and Mycoplasma pneumoniae serology titer level in children suffering from Mycoplasma pneumoniae pneumonia. Keywords: Mycoplasma pneumoniae; MP-IgM; pneumonia in children; thrombocytosis ARTICLE INFO

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Comprehensive detection of causative pathogens using real-time PCR to diagnose pediatric community-acquired pneumonia

Cited by 114 publications

References 44 publications

Prevalence and Risk Factors of Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children in Japan

Prevalence and Risk Factors of Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children in Japan

Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis

Association of Mycoplasma pneumoniae antibody titer level with clinical severity of pneumonia in children

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