2020
DOI: 10.3390/metabo10110442
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Comprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis

Abstract: As the physical properties and functionality of dipeptides differ from those of amino acids, they have attracted attention in metabolomics; however, their functions in vivo have not been clarified in detail. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, and its major cause is chronic hepatitis. This study was conducted to explore tumor-specific dipeptide characteristics by performing comprehensive dipeptide analysis in the tumor and surrounding nontumor tissue of patients with… Show more

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Cited by 20 publications
(11 citation statements)
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“…Notably, three of them are BCAA containing dipeptides (i.e., phenylalanyl-valine, leucylglutamate, and isoleucyl-alanine). Recently, researchers have characterized the increased levels of dipeptides in various cancers (Wu et al, 2013;Li et al, 2019;Ozawa et al, 2020;Stolzenberg-Solomon et al, 2020). More importantly, Li et al recruited 3,482 participants for metabolomics analysis, and BCAA contained dipeptide glutamine-leucine was eventually confirmed as potential metabolic markers for early-stage colorectal cancer (Li et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…Notably, three of them are BCAA containing dipeptides (i.e., phenylalanyl-valine, leucylglutamate, and isoleucyl-alanine). Recently, researchers have characterized the increased levels of dipeptides in various cancers (Wu et al, 2013;Li et al, 2019;Ozawa et al, 2020;Stolzenberg-Solomon et al, 2020). More importantly, Li et al recruited 3,482 participants for metabolomics analysis, and BCAA contained dipeptide glutamine-leucine was eventually confirmed as potential metabolic markers for early-stage colorectal cancer (Li et al, 2019).…”
Section: Discussionmentioning
confidence: 99%
“…In a similar study, the CE‐MS/MS and LC‐MS/MS systems using the same experimental conditions have been applied for comprehensive dipeptide profiling of the tumor and surrounding nontumor tissues of patients with hepatocellular carcinoma (HCC) [228]. Principal component analysis of 236 identified dipeptides revealed differences in the dipeptide profiles between tumor and nontumor tissues.…”
Section: Discussionmentioning
confidence: 99%
“…These are involved in various pathways contributing to cancer cell growth and survival [31], but not much is known about the functional properties of the di-and tri-peptides that had an impact on patient survival in our study. Di-and tripeptides have been suggested as potential disease biomarkers for cancer and have become increasingly the subject of metabolomic studies [32,33]. For instance, the tripeptide N-acetylaspartylglutamylglutamate is produced together with the dipeptide N-acetyl-aspartylglutamate in cells by the same synthetase [34].…”
Section: Discussionmentioning
confidence: 99%