2021
DOI: 10.3390/brainsci11091183
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Comprehensive Evaluation of Factors Affecting Tremor Relapse after MRgFUS Thalamotomy: A Case-Control Study

Abstract: Objective: To identify possible relevant factors contributing to tremor relapse after MRgFUS thalamotomy in patients with essential tremor (ET) and Parkinson’s disease (PD). Methods: We identified patients with tremor relapse from a series of 79 treatments in a single institution. The demographic and clinical characteristics of the study group patients were compared to those of patients who did not relapse in the same follow-up period. Imaging and procedural factors were compared using a control group matched … Show more

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Cited by 14 publications
(13 citation statements)
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“…From a clinical point of view, Parkinsonian tremor is known to relapse more frequently than essential tremor, while gender, age or disease duration are not significant factors. Among the imaging findings, some studies suggest that the size of the thalamotomy lesion may be instrumental in determining the stability of treatment effects [ 11 , 12 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…From a clinical point of view, Parkinsonian tremor is known to relapse more frequently than essential tremor, while gender, age or disease duration are not significant factors. Among the imaging findings, some studies suggest that the size of the thalamotomy lesion may be instrumental in determining the stability of treatment effects [ 11 , 12 ].…”
Section: Discussionmentioning
confidence: 99%
“…Numerous studies have used imaging techniques to demonstrate the presence of structural and functional brain alterations in patients with TE and PD [ 8 , 9 , 10 ]. Some previous reports in the literature also explored the possible prognostic value of imaging finding, using standard and advanced imaging techniques, in patients submitted to pharmacological, surgical, and less invasive treatments for tremor [ 11 , 12 , 13 , 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…Many U.S. centers screen out candidates for MRgFUS with a skull density ratio (SDR) <0. 40 based on screening head CT. Low SDR is associated with increased difficulty focusing the ultrasound beams and achieving therapeutic temperatures at the target. During MRgFUS thalamotomy, the patient's head is shaved and fixed in a stereotactic frame under local anesthesia.…”
Section: Magnetic Resonance-guided Focused Ultrasound (Mrgfus) For Tr...mentioning
confidence: 99%
“…In addition to VIM thalamotomy for ET, others have ablated the dentatorubrothalamic (DRT) tract with MRgFUS with results comparable to VIM thalamotomy [30][31][32]. Incorporation of diffusion tensor imaging (DTI) tractography has been demonstrated in multiple studies to potentially improve targeting and safety of VIM thalamotomy [33][34][35][36][37][38][39][40].…”
Section: Magnetic Resonance-guided Focused Ultrasound (Mrgfus) For Tr...mentioning
confidence: 99%
“…As several other teams worldwide, they are acquiring experience around potential limitations (i.e., skull density ratio and skull volume in the treatment area, which limit the energy transfer throughout the skull and influence the temperature increase in the lesioning area; the number and maximal average temperature-Tmax-Avg-of sonication during treatment; and the accuracy of targeting, the optimal lesion volume), rare adverse events, and the degree of tremor re-occurrence during follow-up (Bruno et al, 2020b(Bruno et al, , 2021bTommasino et al, 2021; Figure 2).…”
Section: Putative Modern Strategies: a Role For Focused Ultrasound?mentioning
confidence: 99%