Comprehensive insight into endothelial progenitor cell-derived extracellular vesicles as a promising candidate for disease treatment

Chen, Ke; Li, Yang; Xu, Luwei; Qian, Yiguan; Liu, Ning; Zhou, Changcheng; Liu, Jingyu; Zhou, Lin; Xu, Zheng; Jia, Ruipeng; Ge, Yu‐Zheng

doi:10.1186/s13287-022-02921-0

Cited by 24 publications

(13 citation statements)

References 194 publications

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“…Despite the special focus on the pluripotent and mesenchymal SC as main sources of EVs for the tissue regeneration, the pro-regenerative potential of EVs secreted by the several other SCs and progenitor cell was also investigated. As an example, therapeutic efficacy of EPCs- derived EVs was shown in different experimental setups ( 111 ). Similarly, protective effect of EVs from neural ( 112 ) and cardiac progenitors ( 113 ) was also demonstrated.…”

Section: Scs-evs As An Alternative Option To Cell-based Therapiesmentioning

confidence: 99%

Stem cell- derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives

2023

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In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted significant attention in the regenerative medicine due to the ability of these cells to proliferate and differentiate into other cell types. However, recent findings have demonstrated that the therapeutic capacity of SCs may also be mediated by their ability to secrete biologically active factors, including extracellular vesicles (EVs). Such submicron circular membrane-enveloped vesicles may be released from the cell surface and harbour bioactive cargo in the form of proteins, lipids, mRNA, miRNA, and other regulatory factors. Notably, growing evidence has indicated that EVs may transfer their bioactive content into recipient cells and greatly modulate their functional fate. Thus, they have been recently envisioned as a new class of paracrine factors in cell-to-cell communication. Importantly, EVs may modulate the activity of immune system, playing an important role in the regulation of inflammation, exhibiting broad spectrum of the immunomodulatory activity that promotes the transition from pro-inflammatory to pro-regenerative environment in the site of tissue injury. Consequently, growing interest is placed on attempts to utilize EVs in clinical applications of inflammatory-related dysfunctions as potential next-generation therapeutic factors, alternative to cell-based approaches. In this review we will discuss the current knowledge on the biological properties of SC-derived EVs, with special focus on their role in the regulation of inflammatory response. We will also address recent findings on the immunomodulatory and pro-regenerative activity of EVs in several disease models, including in vitro and in vivo preclinical, as well as clinical studies. Finally, we will highlight the current perspectives and future challenges of emerging EV-based therapeutic strategies of inflammation-related diseases treatment.

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Section: Scs-evs As An Alternative Option To Cell-based Therapiesmentioning

confidence: 99%

Stem cell- derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives

2023

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“…[ 244,245 ] For instance, EPC‐EVs can accelerate re‐endothelialization via miR‐21‐5p, and suppress IH by inhibiting proliferation and migration of SMCs. [ 246,247 ] EPC‐EVs also positively affect cardiac function by promoting cell growth and angiogenesis depending on their miRNAs. [ 196,246 ] Chen et al.…”

Section: Diagnosis and Therapymentioning

confidence: 99%

Recent Advances in Cell‐Based Nanotherapy for Cardiovascular Diseases

Hao

2023

Macromolecular Bioscience

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Cell‐based nanotherapy holds great potential to transform diagnosis and treatment patterns for human diseases, especially for cardiovascular diseases (CVDs). Surface coating with cell membrane has become a powerful strategy for functionalization of therapeutic nanoparticles to achieve biological performances of superior biocompatibility, immune evasion, and specificity. Additionally, extracellular vesicles (EVs) play key roles in the progression of CVDs with their ability of transferring cargos to distant tissues, thus emerging as an appealing option for the diagnosis and therapy of CVDs. In this review, recent progress in cell‐based nanotherapy for CVDs is summarized, and different sources of EVs and biomimetic nanoplatforms derived from natural cells are highlighted. Meanwhile, their promising biomedical applications in the diagnosis and targeted treatment of different CVDs are also provided, followed by a discussion of their potential challenges and future prospects.

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“…Exosomes can transport therapeutic agents through membranes, thus allowing for the involvement in both autocrine and paracrine signaling via the delivery of proteins and RNAs essential for angiogenesis that occurs under ischemic conditions [ 47 , 48 ]. Proteins and miRNAs are key regulators, highly expressed in exosomes, that promote angiogenesis and intracellular communications, which ultimately affect growth factors and gene expression [ 49 , 50 ] ( Figure 2 ).…”

Section: Relationship Between Exosomes and Mechanisms Associated With...mentioning

confidence: 99%

Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment

Lee

et al. 2022

IJMS

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Stroke is the leading cause of death and neurological disorders worldwide. However, diagnostic techniques and treatments for stroke patients are still limited for certain types of stroke. Intensive research has been conducted so far to find suitable diagnostic techniques and treatments, but so far there has been no success. In recent years, various studies have drawn much attention to the clinical value of utilizing the mechanism of exosomes, low toxicity, biodegradability, and the ability to cross the blood–brain barrier. Recent studies have been reported on the use of biomarkers and protective and recovery effects of exosomes derived from stem cells or various cells in the diagnostic stage after stroke. This review focuses on publications describing changes in diagnostic biomarkers of exosomes following various strokes and processes for various potential applications as therapeutics.

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Comprehensive insight into endothelial progenitor cell-derived extracellular vesicles as a promising candidate for disease treatment

Cited by 24 publications

References 194 publications

Stem cell- derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives

Stem cell- derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives

Recent Advances in Cell‐Based Nanotherapy for Cardiovascular Diseases

Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment

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