Comprehensive Kinetics and a Mechanistic Investigation on the Biological Active Pyrano[2,3-C]Pyrazole Core in the Presence of Both Eco-Friendly Catalyst and Solvent: Experimental Green Protocol

Talaiefar, Sadegh; Habibi‐Khorassani, Sayyed Mostafa; Shaharaki, Mehdi

doi:10.1080/10406638.2020.1751667

Cited by 10 publications

(4 citation statements)

References 105 publications

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“…Sadegh Talaiefar et al [29] . synthesize biological active pyrano [2, 3‐C] pyrazole (6) core in the presence of both eco‐friendly catalyst and solvent.…”

Section: All Green Approaches For Pyrazole Synthesismentioning

confidence: 99%

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Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Sapkal¹,

Kamble²

2020

ChemistrySelect

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Pyrazole and its derivatives are one of the interesting heterocyclic compounds among the other because it has tremendous important bio-medical applications such as anticancer, antimalarial, antimicrobial, antifungal, antitubercular and antihelishmanial. Synthesis of pyrazoles by synthetic route requires harsh reaction conditions such as organic solvent, high temperature, require large time that consume more energy which increase final cost of the synthesis of pyrazoles. Therefore researchers be aware about synthesis and give more attention towards to develop a greener as well as economically favorable method for synthesis of pyrazoles such as microwave irradiation, ultra-sonication assisted, reaction at room temperature, solvent and catalyst free and use of universal solvent that is aqueous medium these techniques are environmentally friendly as well as cost effective. Therefore, these review highlights the greener methodologies for the synthesis of pyrazoles, which are good alternative for synthetic methods that sustains green principles.

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“…Sadegh Talaiefar et al [29] . synthesize biological active pyrano [2, 3‐C] pyrazole (6) core in the presence of both eco‐friendly catalyst and solvent.…”

Section: All Green Approaches For Pyrazole Synthesismentioning

confidence: 99%

“…Sadegh Talaiefar et al [29] synthesize biological active pyrano [2, 3-C] pyrazole (6) core in the presence of both eco-friendly catalyst and solvent. It is MCR's of ethyl acetoacetate, hydrazine hydrate, malononitrile and substituted aryl aldehydes using sodium benzoate base catalyst in the water at 15°C (scheme 6).…”

Section: Aqueous Medium Synthesismentioning

confidence: 99%

Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Sapkal¹,

Kamble²

2020

ChemistrySelect

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“…Various synthetic compounds with heterocyclic moieties have become recognized for their antiviral properties [ 27 , 28 ]. Therefore, pyranopyrazole moieties and their annulated systems are a special structure of bioactive fused heterocyclic structures that have developed attentive significance in biochemistry due to their various pharmacological and biological efficiencies such as human Chk1 kinase inhibitors [ 29 ], antimicrobial agents [ 30 ], molluscicidal agents [ 31 ], analgesic [ 32 ], anti-bacterial [ 33 ], anti-inflammatory [ 22 ], antiproliferative [ 34 ], antifungal [ 35 ], anti-depressant [ 36 ], antioxidant [ 37 ], antimalarial [ 38 ], α-glucosidase inhibitors [ 39 ], anti-cancer [ 40 ], biodegradable agrochemicals [ 41 ], and anti-Alzheimer efficiencies [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Discovery of Pyrano[2,3-c]pyrazole Derivatives as Novel Potential Human Coronavirus Inhibitors: Design, Synthesis, In Silico, In Vitro, and ADME Studies

Allayeh,

El-boghdady,

Said

et al. 2024

Pharmaceuticals

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The SARS-CoV-2 pandemic at the end of 2019 had major worldwide health and economic consequences. Until effective vaccination approaches were created, the healthcare sectors endured a shortage of operative treatments that might prevent the infection’s spread. As a result, academia and the pharmaceutical industry prioritized the development of SARS-CoV2 antiviral medication. Pyranopyrazoles have been shown to play a prominent function in pharmaceutical chemistry and drug sighting because of their significant bioactive properties. We provide herein a novel sequence of pyranopyrazoles and their annulated systems whose antiviral efficacy and cytotoxicity were explored versus human coronavirus 229E (HCoV-229E) Vero-E6 cell lines as a model for the Coronaviridae family. Fifteen synthetic congeners pointed out miscellaneous antiviral efficacies against HCoV-229E with variable inhibition degrees. Compound 18 showed a high selectivity index (SI = 12.6) that established spectacular inhibitory capacity against human coronavirus 229E. Compounds 6, 7, and 14 exposed moderate efficacies. Compounds 6, 7, 14, and 18 exhibited substantial antiviral action through the replication phase with reduction percentages extending from 53.6%, 60.7%, and 55% to 82.2%, correspondingly. Likewise, when assessed to the positive control tipranavir (88.6%), the inhibitory efficiency of compounds 6, 7, 14, and 18 versus the SARS-CoV2 Mpro provided high percentages of 80.4%, 73.1%, 81.4% and up to 84.5%, respectively. In silico studies were performed to investigate further the biological activity and the target compounds’ physical and chemical features, including molecular dynamic (MD) simulations, protein–ligand docking, ADME studies, and density functional theory (DFT) calculations. These inquiries demonstrated that this series of metabolically stable pyranopyrazoles and their annulated systems are effective human coronavirus inhibitors that inhibit the viral Mpro protein and may have emerged as a novel COVID-19 curative option.

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“…The base catalyst sodium benzoate was applied by Habibi-Khorassani and co-workers in the synthesis of biologically active pyranopyrazoles 12 (Scheme 43) 88. …”

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confidence: 99%

Green Synthesis of Pyrazoles: Recent Developments in Aqueous Methods

Singh

Yadav²,

Yadav

et al. 2023

SynOpen

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Organic syntheses by adopting green protocols such as sonochemical procedures, microwave technologies, solvent-free conditions, green solvent, heterogeneous catalysis particularly nanocatalysts, ionic liquids have replaced the traditional procedures due to concerns pertaining especially to environment. The heterocycle, pyrazole, due to its multifaceted applications has been the cyanosure of the chemists and therefore various synthetic approaches have been developed to synthesize the pyrazole containing molecules. In the present compilation, we have summarized the recent water-based research work on the synthesis of pyrazoles. Key words: Green chemistry, environment friendly, water based synthesis, pyrazoles

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Comprehensive Kinetics and a Mechanistic Investigation on the Biological Active Pyrano[2,3-C]Pyrazole Core in the Presence of Both Eco-Friendly Catalyst and Solvent: Experimental Green Protocol

Cited by 10 publications

References 105 publications

Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Greener and Environmentally Benign Methodology for the Synthesis of Pyrazole Derivatives

Discovery of Pyrano[2,3-c]pyrazole Derivatives as Novel Potential Human Coronavirus Inhibitors: Design, Synthesis, In Silico, In Vitro, and ADME Studies

Green Synthesis of Pyrazoles: Recent Developments in Aqueous Methods

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