Comprehensive mineralogical and physicochemical characterization of recent sapropels from Romanian saline lakes for potential use in pelotherapy

Baricz, Andreea; Levei, Erika Andrea; Șenilă, Marin; Pinzaru, Simona Cîntă; Aluaş, Mihaela; Vulpoi, Adriana; Filip, Claudiu; Tripon, Carmen; Dădârlat, D.; Buda, Doriana M.; Dulf, Francisc Vasile; Pintea, Adela; Cristea, Adorján; Muntean, Vasile; Keresztes, Zsolt Gyula; Alexe, Mircea; Banciu, Horia Leonard

doi:10.1038/s41598-021-97904-1

Cited by 7 publications

(5 citation statements)

References 46 publications

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“…The content of heavy metals is below the standard values adopted by the US EPA (EPA, 2012 ). A comparative analysis of the composition of heavy metals shows that the peloids of Western Kazakhstan have mostly similar content of manganese, zinc, copper, lead, and cadmium with sapropels from Romanian saline lakes (Baricz et al, 2021 ), as well as zinc and lead with peloids from Ulcinj coast, Montenegro (Potpara et al, 2017 ), and San Diego de los Baños Thermal Center, Cuba (Suárez Muñoz et al, 2015 ). Comparing the available data from other countries, the mud of Southern and Western Kazakhstan has a low copper content; however, it has a high cadmium content.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and physicochemical properties of natural therapeutic mud of Kazakhstan salt lakes: a review

Akimzhanova,

Sabitova,

Mussabayeva

et al. 2024

Environ Geochem Health

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In recent years, interest in natural therapeutic mud has been growing all over the world. This natural product has a positive therapeutic effect on the skin and has fewer side effects on the human body. There are more than 40 thousand salt lakes in Kazakhstan. Most of them have natural mud sources, the potential of which has not yet been fully explored. The review presents an analysis of the available information on the physical and chemical properties of the main sources of natural mud from salt lakes in Kazakhstan and Kazakh sanatoriums that use natural mud in the treatment. All available publications, presenting the systematic studies, were used for data analysis. A comparative analysis of the mineralization of water, brine, and silt in one reservoir shows that the mineralization of water is not always the least. The available data indicate a point and partial nature of peloid studies, e.g., inorganic composition of natural muds from Western and Southern Kazakhstan is well described in the literature. In turn, there is a lack of these data from Northern and Eastern Kazakhstan. Studies of peloids in these regions seem to be a promising direction of the future research for both local and world scientists. What is more, there is also a big gap in the analysis of organic matter of muds from the Kazakh lakes. Comparing the state of the art, i.e., the studies from other parts of Asia and Europe, the identification of the organic part of muds is another desirable direction as a potential source of biologically active compounds of natural origin.

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Section: Resultsmentioning

confidence: 99%

Chemical composition and physicochemical properties of natural therapeutic mud of Kazakhstan salt lakes: a review

Akimzhanova,

Sabitova,

Mussabayeva

et al. 2024

Environ Geochem Health

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“…To determine carotenoids and chlorophylls in medicinal plant raw materials use the method of liquid chromatography-mass spectrometry [24], high performance liquid chromatography (HPLC) [25]. For simultaneous detection of carotenoids and chlorophylls in sapropels use the method of high-performance liquid chromatography (HPLC) (HPLC-UV-VIS) [26], as well as the method of HPLC with photodiodes with UV -detection in the visible region and atmospheric pressure (High performance liquid chromatography with photodiode array UV -Vis detection and atmospheric pressure chemical ionization mass spectrometry) [27] and Raman spectroscopy [28].…”

Section: Discussionmentioning

confidence: 99%

Development of methods of identification and quantitative determination of active substances in semi-solid dosage forms with sapropel extracts

Strus¹,

Polovko²,

Gushcha³

et al. 2021

Eureka: HS

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For use in veterinary medicine for the treatment of the wound process and the prevention of mastitis, the composition and technology of an emulsion-based cream, conventionally called “Saprocream”, has been developed. Clinical trial of the drug “Saprocream” proved its effectiveness and safety for use in the healing of microtraumas, erosions and cracks (wounds) of the udders of cows. The aim of the research were was the standardization of the cream under the conventional name “Saprocream” for use in veterinary medicine as a wound healing agent, the development of methods of identification and quantification and their validation. Materials and methods. Test samples of emulsion cream type o / v, containing 15 % aqueous extract of sapropel (VES), 10 % oil extract of sapropel (OES), 6 % emulsifier No. 1, 1 % cetylstearyl alcohol, preservatives – 0.01 % nisin, 0.1 % euxil K 100 and purified water up to 100 g were made by phase inversion. The methods of pharmacopoeial articles of the European Pharmacopoeia of the 10th edition, SPhU 1.0, as well as industry standards were used to develop methods for identification and quantification of active pharmaceutical ingredients (API) in the developed cream and its standardization. Results. The chromatographic profile of the acetone extract from the cream coincides with the chromatographic profile of the reference solution ((PRS) β-carotene), which indicates the presence of substances of carotenoid structure. The absorption spectrum of hexane extraction from the cream in the range from 500 nm to 750 nm has a maximum absorption at a wavelength of 670±2 nm, which coincides with the maximum absorption of hexane solution OES, indicating the presence of chlorophyll. A method for quantifying the total mass fraction of humic acids (HA) has been developed and it has been established that the total mass fraction of HA in cream samples with sapropel extracts is 0.828 %. The results of the validation of the method show that there is a linear relationship between the concentration of the total mass fraction of HA and the mass of the AES sample with a correlation coefficient of 0.9981 (³ 0.9981). The developed technique is precise, because the value of the relative confidence interval is less than the critical value for the convergence of the results: D %=1.34≤1.60 and the criterion of insignificance of systematic error d=0.51 is fulfilled. Conclusions. An emulsion-based cream under the conventional name “Saprocream” has been standardized, methods for identification and quantification of active substances have been developed and validation of the developed methods for use in veterinary medicine as a wound-healing and anti-inflammatory agent has been carried out.

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“…The chemical composition of natural muds, their physical properties, as well as the therapeutic effect are studied by researchers in different countries. A comprehensive physical and chemical study of mud was described, including the determination of pH, granulometry, chemical, and mineralogical composition, organic matter in Romania (Baricz et al, 2021), in Montenegro (Potpara et al, 2017), in Turkey (Odabasi et al, 2007), in Cuba (Martínez-Villegas et al, 2020. The factors influencing the formation of the chemical composition and genesis of silt mud include the salt composition of the brine of the reservoir, soil, and organic matter of plant and animal origin.…”

Section: с уважением благотворительный фонд «халык»!mentioning

confidence: 99%

Chemical Characteristic of the Black and White Mud of the Shoshkaly Lake

Akimzhanova,

Sabitova,

Kairbekov

et al. 2023

SCT

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doctor of chemistry, professor, academician of NAS RK, president of NAS RK, general director of JSC "Institute of fuel, catalysis and electrochemistry named after D.V. Sokolsky (Almaty, Kazakhstan) H = 4 Editorial board: ADEKENOV Sergazy Mynzhasarovich (deputy editor-in-chief) doctor of chemical sciences, professor, academician of NAS RK, director of the international Scientific and production holding «Phytochemistry» (Karaganda, Kazakhstan) H = 11 AGABEKOV Vladimir Enokovich (deputy editor-in-chief), doctor of chemistry, professor, academician of NAS of Belarus, honorary director of the Institute of Chemistry of new materials (Minsk, Belarus) H = 13 STRNAD Miroslav, head of the laboratory of the institute of Experimental Botany of the Czech academy of sciences, professor (Olomouc, Czech Republic) H = 66 BURKITBAYEV Mukhambetkali, doctor of chemistry, professor, academician of NAS RK, first vice-rector of al-Farabi KazNU (Almaty, Kazakhstan) H = 11 HOHMANN Judith, head of the department of pharmacognosy, faculty of Pharmacy, university of Szeged, director of the interdisciplinary center for Life sciences (Szeged, ungary) H = 38 ROSS Samir, Ph.D, professor, school of Pharmacy, national center for scientific research of Herbal Products, University of Mississippi (Oxford, USA) H = 35 KHUTORYANSKY Vitaly, Ph.D, pharmacist, professor at the University of Reading (Reading, England) H = 40 TELTAYEV Bagdat Burkhanbayuly, doctor of technical sciences, professor, corresponding member of NAS RK, ministry of Industry and infrastructure development of the Republic of Kazakhstan (Almaty, Kazakhstan) H = 13 PHARUK Asana Dar, professor at Hamdard al-Majid college of Oriental medicine. faculty of Oriental medicine, Hamdard university (Karachi, Pakistan) H = 21 FAZYLOV Serik Drakhmetovich, doctor of chemistry, professor, academician of NAS RK, deputy director for institute of Organic synthesis and coal chemistry (Karaganda, Kazakhstan) H = 6 ZHOROBEKOVA Sharipa Zhorobekovna, doctor of chemistry, professor, academician of NAS of Kyrgyzstan, Institute of Chemistry and chemical technology of NAS KR (Bishkek, Kyrgyzstan) H = 4 KHALIKOV Jurabay Khalikovich, doctor of chemistry, professor, academician of the academy of sciences of tajikistan, institute of Chemistry named after V.I. Nikitin AS RT (Tajikistan) H = 6 FARZALIEV Vagif Medzhid ogly, doctor of chemistry, professor, academician of NAS of Azerbaijan (Azerbaijan) H = 13 GARELIK Hemda, PhD in chemistry, president of the department of Chemistry and Environment of the International Union of Pure and Applied Chemistry (London, England) H = 15 News of the National Academy of Sciences of the Republic of Kazakhstan. Series of chemistry and technology.

show abstract

Comprehensive mineralogical and physicochemical characterization of recent sapropels from Romanian saline lakes for potential use in pelotherapy

Cited by 7 publications

References 46 publications

Chemical composition and physicochemical properties of natural therapeutic mud of Kazakhstan salt lakes: a review

Chemical composition and physicochemical properties of natural therapeutic mud of Kazakhstan salt lakes: a review

Development of methods of identification and quantitative determination of active substances in semi-solid dosage forms with sapropel extracts

Chemical Characteristic of the Black and White Mud of the Shoshkaly Lake

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