2021
DOI: 10.1101/2021.01.06.425584
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Comprehensive multi-omics study of the molecular perturbations induced by simulated diabetes on coronary artery endothelial cells

Abstract: Coronary artery endothelial cells (CAEC) exert an important role in the development of cardiovascular disease. Dysfunction of CAEC is associated with cardiovascular disease in subjects with type 2 diabetes mellitus (T2DM). However, comprehensive studies of the effects that a diabetic environment exerts on this cellular type scarce. The present study characterized the molecular perturbations occurring on cultured bovine CAEC subjected to a prolonged diabetic environment (high glucose [HG] and high insulin [HI])… Show more

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