Comprehensive Overview of Non-coding RNAs in Cardiac Development

Pozzo, Enrico; Chai, Yoke Chin; Sampaolesi, Maurilio

doi:10.1007/978-981-15-1671-9_11

Cited by 4 publications

(2 citation statements)

References 107 publications

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“…T-box family members such as Tbx2 [173][174][175][176][177][178], Tbx3 [179][180][181][182], Tbx5 [137,138], and Tbx20 [186,187] play a fundamental role instructing these signals [188][189][190] while atrial and ventricular identities are orchestrated by Irx [191][192][193], Hey [194][195][196], and Coup-TF [198] family members. Several non-coding RNAs are differentially expressed during cardiogenesis [334][335][336][337][338], some of which regulate distinct cardiac enriched transcription factors such as Mef2c [334] while other such as miR-25 promotes cardiomyocyte proliferation [336] while others such as miR-143 and miR-138 are essential for cardiac chamber morphogenesis [339,340].…”

Section: Cardiac Ballooning and The Configuration Cardiac Conductive mentioning

confidence: 99%

Cardiac Development: A Glimpse on Its Translational Contributions

Franco

García-Padilla

Domínguez

et al. 2021

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Cardiac development is a complex developmental process that is initiated soon after gastrulation, as two sets of precardiac mesodermal precursors are symmetrically located and subsequently fused at the embryonic midline forming the cardiac straight tube. Thereafter, the cardiac straight tube invariably bends to the right, configuring the first sign of morphological left–right asymmetry and soon thereafter the atrial and ventricular chambers are formed, expanded and progressively septated. As a consequence of all these morphogenetic processes, the fetal heart acquired a four-chambered structure having distinct inlet and outlet connections and a specialized conduction system capable of directing the electrical impulse within the fully formed heart. Over the last decades, our understanding of the morphogenetic, cellular, and molecular pathways involved in cardiac development has exponentially grown. Multiples aspects of the initial discoveries during heart formation has served as guiding tools to understand the etiology of cardiac congenital anomalies and adult cardiac pathology, as well as to enlighten novels approaches to heal the damaged heart. In this review we provide an overview of the complex cellular and molecular pathways driving heart morphogenesis and how those discoveries have provided new roads into the genetic, clinical and therapeutic management of the diseased hearts.

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Section: Cardiac Ballooning and The Configuration Cardiac Conductive mentioning

confidence: 99%

Cardiac Development: A Glimpse on Its Translational Contributions

Franco

García-Padilla

Domínguez

et al. 2021

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“…In injured skeletal muscles, several chemokines, growth factors and eventually recombinant proteins (4,5), play a crucial role in the stem cell machinery. Although satellite cells are the main players in skeletal muscle development and repair, other local progenitors, including mesoangioblasts (MABs) have been showed to directly contribute to muscle repair (6)(7)(8)(9)(10)(11)(12). MABs were originally isolated from murine dorsal aorta and subsequently identified in murine and human adult skeletal muscles associated with small interstitial vessels.…”

Section: Introductionmentioning

confidence: 99%

State of the Art Procedures for the Isolation and Characterization of Mesoangioblasts

Giarratana¹,

Conti²,

Rinvenuti³

et al. 2023

Methods in Molecular Biology

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Adult skeletal muscle is a dynamic tissue able to regenerate quite efficiently thanks to the presence of a stem cell machinery. Besides the quiescent satellite cells that are activated upon injury or paracrine factors other stem cells are described to be directly or indirectly involved in adult myogenesis. Mesoangioblasts (MABs) are vessel-associated stem cells originally isolated form embryonic dorsal aorta and then from adult muscle interstitia expressing pericyte markers.Recently, adult MABs entered clinical trials for the treatment of Duchenne muscular dystrophy and the transcriptome of human fetal MABs has been described. In addition, single cell RNA-seq analyses provide novel information on adult murine MABs and more in general in interstitial muscle stem cells. This chapter provides the state-of-the-art techniques to isolate and characterize murine MABs, fetal and adult human MABs.

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The molecular mechanisms of cardiac development and related diseases

Li,

Du,

Deng

et al. 2024

Sig Transduct Target Ther

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Cardiac development is a complex and intricate process involving numerous molecular signals and pathways. Researchers have explored cardiac development through a long journey, starting with early studies observing morphological changes and progressing to the exploration of molecular mechanisms using various molecular biology methods. Currently, advancements in stem cell technology and sequencing technology, such as the generation of human pluripotent stem cells and cardiac organoids, multi-omics sequencing, and artificial intelligence (AI) technology, have enabled researchers to understand the molecular mechanisms of cardiac development better. Many molecular signals regulate cardiac development, including various growth and transcription factors and signaling pathways, such as WNT signaling, retinoic acid signaling, and Notch signaling pathways. In addition, cilia, the extracellular matrix, epigenetic modifications, and hypoxia conditions also play important roles in cardiac development. These factors play crucial roles at one or even multiple stages of cardiac development. Recent studies have also identified roles for autophagy, metabolic transition, and macrophages in cardiac development. Deficiencies or abnormal expression of these factors can lead to various types of cardiac development abnormalities. Nowadays, congenital heart disease (CHD) management requires lifelong care, primarily involving surgical and pharmacological treatments. Advances in surgical techniques and the development of clinical genetic testing have enabled earlier diagnosis and treatment of CHD. However, these technologies still have significant limitations. The development of new technologies, such as sequencing and AI technologies, will help us better understand the molecular mechanisms of cardiac development and promote earlier prevention and treatment of CHD in the future.

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Comprehensive Overview of Non-coding RNAs in Cardiac Development

Cited by 4 publications

References 107 publications

Cardiac Development: A Glimpse on Its Translational Contributions

Cardiac Development: A Glimpse on Its Translational Contributions

State of the Art Procedures for the Isolation and Characterization of Mesoangioblasts

The molecular mechanisms of cardiac development and related diseases

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