Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer

Guo, Jianghong; Jin, Li; Chang-li, Zhu; Feng, Wei; Shao, Jing-xian; Wan, Li; Huang, Ming‐De; He, Jie

doi:10.2147/ott.s123220

Cited by 136 publications

(112 citation statements)

References 10 publications

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“…Yet, with the development of modern technology, people find that they are abundant in eukaryotes (Rybak‐Wolf et al, ), and are involved in many diseases, including different cancers (Hansen, Kjems, & Damgaard, ; Peng, Yuan, & Li, ; Wang et al, ). In fact, people have found that many CircRNAs were disregulated in cancers, such as CircRNA_0000069 in colorectal cancer (Guo et al, ) and CircRNA_0001649 in liver cancer (Qin et al, ), thus CircRNA can function as a biomarker for cancer (Meng et al, ; Qin et al, ; Shang et al, ; Yu et al, ). As far as we know, no report has reported the role of CircRNA_101996 in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR‐8075

Song

Zhang

et al. 2019

Journal Cellular Physiology

169

117

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In recent years, circular RNAs have been shown to serve as essential regulators in several human cancers. Nevertheless, the function and mechanism of CircRNA in cervical cancer remain elusive. In the present study, we showed that hsa_circRNA_101996 was highly expressed in cervical cancer tissues compared with matched normal tissues by bioinformatics analysis. We showed that the expression level of hsa_circRNA_101996 in cervical cancer tissues was positively correlated with TNM stage, tumor size, and lymph node metastasis. Moreover, higher levels of hsa_circRNA_101996 were related to poor outcomes of cervical cancer patients. We found that knockdown of hsa_circRNA_101996 significantly inhibited the proliferation, cell cycle, migration, and invasion of cervical cancer cells. Mechanistically, we demonstrated that hsa_circRNA_101996 served as a sponge of miR‐8075, which targeted TPX2 in cervical cancer cells. We showed that miR‐8075 that was downregulated in cervical cancer tissues repressed cervical cancer cell proliferation, migration, and invasion. Furthermore, we validated that upregulation of TPX2 by hsa_circRNA_101996‐mediated inhibition of miR‐8075 contributed to cervical cancer proliferation, migration, and invasion. Taken together, our findings revealed a novel mechanism that hsa_circRNA_101996‐miR‐8075‐TPX2 network promoted cervical cancer progression.

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Section: Discussionmentioning

confidence: 99%

CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR‐8075

Song

Zhang

et al. 2019

Journal Cellular Physiology

169

117

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“…CircRNAs are a family of novel ncRNAs that play important roles in CRC tumorigenesis. For example, J. Guo et al () showed that hsa_circ_0000069 was upregulated and promoted cell proliferation, migration, and invasion in CRC. Zhu, Xu, and Chen () indicated that circBANP was overexpressed in CRC tissues.…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR‐136/SH2B1 axis

Jin

Wang

Linbo

et al. 2018

Journal Cellular Physiology

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Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Currently, an increasing evidence showed that circular RNAs (circRNAs) play important roles in tumor progression. However, the effects and underlying mechanisms of circRNAs in CRC progression remain unclear. In the present study, through circRNA high-throughput sequencing and quantitative real-time polymerase chain reaction, we identified that hsa_circ_0136666 was significantly overexpressed in CRC tissues and cell lines. High hsa_circ_0136666 expression was associated with poor overall survival of patients with CRC. In vitro function assays showed that hsa_circ_0136666 inhibition suppressed CRC cell proliferation, migration, invasion, and arrested CRC cells in the G0/G1 phase. Furthermore, we showed that hsa_circ_0136666 inhibition reduced CRC cell growth in vivo. Mechanistically, we revealed that hsa_circ_0136666 could increase SH2B1 expression via competitively binding miR-136 in CRC cells. In addition, SH2B1 overexpression could reverse the effects of hsa_circ_0136666 inhibition on CRC cell progression. In conclusion, our data suggested that hsa_circ_0136666 could promote CRC cell progression via the miR-136/SH2B1 axis, elucidating a novel approach to improve the effectiveness of CRC treatment. K E Y W O R D Scolorectal cancer (CRC), hsa_circ_0136666, miR-136, SH2B1

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“…For instance, ciRS-7 depletion indirectly leads to a reduction of the ubiquitin conjugating enzyme UBE2A via excessive miRNA-7 in Alzheimer's disease [49]. The upregulation of hsa_circ_001569 and hsa_circ_0000069 augments cell proliferation, migration, and invasion, and hsa_circ_001988 downregulation is used as an indicator in colorectal cancer [50][51][52]. CircPVT1 was believed to be a proliferative effector and a prognostic factor based on an analysis of RNA-sequencing data in gastric cancer [53].…”

Section: Discussionmentioning

confidence: 99%

Profiles and Bioinformatics Analysis of Differentially Expressed Circrnas in Taxol-Resistant Non-Small Cell Lung Cancer Cells

Chen

Liu

et al. 2018

Cell Physiol Biochem

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Background/Aims: Circular RNAs (circRNAs) act as microRNA (miRNA) sponges that regulate gene expression and are involved in physiological and pathological processes. In this study, we evaluated the roles of circRNAs in the chemoresistance of non-small cell lung cancer (NSCLC) to taxol. Methods: High-throughput circRNA microarrays were employed to investigate the circRNA profiles of parental A549 and taxol-resistant A549/Taxol cells. We predicted the miRNA targets of differentially expressed circRNAs via miRNA prediction software and then constructed a circRNA/miRNA network using Cytoscape. Bioinformatics analyses were performed to annotate dysregulated circRNAs in detail. Results: We detected 2909 significantly upregulated and 8372 downregulated circRNAs in A549/Taxol cells compared with A549 cells. The circRNA/miRNA network displayed their interactions, suggesting that circRNAs exert biological effects by absorbing and sequestering miRNA molecules. Computational Gene Ontology and pathway analyses were used to determine the biological function and signaling pathways of host genes of dysregulated circRNAs and to identify potential molecular mechanisms prompting the resistance of NSCLC to taxol. Conclusion: This study focusing on circRNAs related to taxol resistance provides a basis for clarifying the development and progression of drug resistance and for identifying therapeutic targets in NSCLC.

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Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer

Cited by 136 publications

References 10 publications

CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR‐8075

CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR‐8075

Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR‐136/SH2B1 axis

Profiles and Bioinformatics Analysis of Differentially Expressed Circrnas in Taxol-Resistant Non-Small Cell Lung Cancer Cells

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