Abstract:19The spread of mcr-1 in human and veterinary medicine has jeopardized the use of 20 polymyxins, the last-resort antibiotics against life-threatening multidrug-resistant 21 Gram-negative bacteria. As a lipid-modified gene, whether mcr-1 brings proteomic and 22 metabolomic changes in the bacteria and affects the corresponding metabolic pathway 23 is largely unknown. Herein, we used label-free quantitative proteomics and untargeted 24 metabolomics to profile comprehensive proteome and metabolome characteristics … Show more
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