Comprehensive Study of Phase-Sensitive SPR Sensor Based on Metal–ITO Hybrid Multilayer

Han, Lei; Zhao, Xiang; Huang, Tianye; Ding, Huafeng; Wu, Chi‐Man Lawrence

doi:10.1007/s11468-019-00968-z

Cited by 27 publications

(10 citation statements)

References 41 publications

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“…Compared with traditional detection technology, SPR detection technology has outstanding advantages [ 105 , 106 , 107 ]. (1) Label-free feature.…”

Section: Spr-based Biosensorsmentioning

confidence: 99%

Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

Lin

et al. 2022

Biosensors

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The outbreak of Corona Virus Disease 2019 (COVID-19) has again emphasized the significance of developing rapid and highly sensitive testing tools for quickly identifying infected patients. Although the current reverse transcription polymerase chain reaction (RT-PCR) diagnostic techniques can satisfy the required sensitivity and specificity, the inherent disadvantages with time-consuming, sophisticated equipment and professional operators limit its application scopes. Compared with traditional detection techniques, optical biosensors based on nanomaterials/nanostructures have received much interest in the detection of SARS-CoV-2 due to the high sensitivity, high accuracy, and fast response. In this review, the research progress on optical biosensors in SARS-CoV-2 diagnosis, including fluorescence biosensors, colorimetric biosensors, Surface Enhancement Raman Scattering (SERS) biosensors, and Surface Plasmon Resonance (SPR) biosensors, was comprehensively summarized. Further, promising strategies to improve optical biosensors are also explained. Optical biosensors can not only realize the rapid detection of SARS-CoV-2 but also be applied to judge the infectiousness of the virus and guide the choice of SARS-CoV-2 vaccines, showing enormous potential to become point-of-care detection tools for the timely control of the pandemic.

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“…Compared with traditional detection technology, SPR detection technology has outstanding advantages [ 105 , 106 , 107 ]. (1) Label-free feature.…”

Section: Spr-based Biosensorsmentioning

confidence: 99%

Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

Lin

et al. 2022

Biosensors

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Section: Optical Biosensors Based On 2d Materialsmentioning

confidence: 99%

“…For example, a fluorine-based optical fiber sensor is suitable for the simulation and analysis of liver malignant tumors, and its structure is shown in Figure 15e. [141] Other hybrid structures, such as SPR biosensor based on indium tin oxide (ITO)-WS 2 hybrid structure, have significantly improved performance compared with traditional metal-based SPR sensors, [142] as shown in Figure 15f. This is because ITO is a mixture of In 2 O 3 and SnO 2 , and has the advantages of adjustable dielectric constant, small capacitance, and high transmittance.…”

Section: Wsmentioning

confidence: 99%

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2D Material‐Based Optical Biosensor: Status and Prospect

2021

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The combination of 2D materials and optical biosensors has become a hot research topic in recent years. Graphene, transition metal dichalcogenides, black phosphorus, MXenes, and other 2D materials (metal oxides and degenerate semiconductors) have unique optical properties and play a unique role in the detection of different biomolecules. Through the modification of 2D materials, optical biosensor has the advantages that traditional sensors (such as electrical sensing) do not have, and the sensitivity and detection limit are greatly improved. Here, optical biosensors based on different 2D materials are reviewed. First, various detection methods of biomolecules, including surface plasmon resonance (SPR), fluorescence resonance energy transfer (FRET), and evanescent wave and properties, preparation and integration strategies of 2D material, are introduced in detail. Second, various biosensors based on 2D materials are summarized. Furthermore, the applications of these optical biosensors in biological imaging, food safety, pollution prevention/control, and biological medicine are discussed. Finally, the future development of optical biosensors is prospected. It is believed that with their in-depth research in the laboratory, optical biosensors will gradually become commercialized and improve people's quality of life in many aspects.

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“…Surface plasmon resonance (SPR) is a kind of highly sensitive real-time spectral phenomenon, which can be used to measure the refractive index change on the surface of the metal film [1]. The optical biosensor based on SPR technology has many advantages, such as high sensitivity, real-time monitoring of the dynamic process of the reaction, label the biological sample, and no background interference [2][3][4]. In the past few years, SPR-based biosensors have developed rapidly in environmental monitoring, medical diagnosis, food safety detection, and so on [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Giant Goos-Hänchen Shifts in Au-ITO-TMDCs-Graphene Heterostructure and Its Potential for High Performance Sensor

Han

Pan

et al. 2020

Sensors

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In order to improve the performance of surface plasmon resonance (SPR) biosensor, the structure based on two-dimensional (2D) of graphene and transition metal dichalcogenides (TMDCs) are proposed to greatly enhance the Goos-Hänchen (GH) shift. It is theoretically proved that GH shift can be significantly enhanced in SPR structure coated with gold (Au)-indium tin oxide (ITO)-TMDCs-graphene heterostructure. In order to realize high GH shifts, the number of TMDCs and graphene layer are optimized. The highest GH shift (−801.7 λ) is obtained by Au-ITO-MoSe2-graphene hybrid structure with MoSe2 monolayer and graphene bilayer, respectively. By analyzing the GH variation, the index sensitivity of such configuration can reach as high as 8.02 × 105 λ/RIU, which is 293.24 times of the Au-ITO structure and 177.43 times of the Au-ITO-graphene structure. The proposed SPR biosensor can be widely used in the precision metrology and optical sensing.

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Comprehensive Study of Phase-Sensitive SPR Sensor Based on Metal–ITO Hybrid Multilayer

Cited by 27 publications

References 41 publications

Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

2D Material‐Based Optical Biosensor: Status and Prospect

Giant Goos-Hänchen Shifts in Au-ITO-TMDCs-Graphene Heterostructure and Its Potential for High Performance Sensor

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