Comprehensive Study on Solomonamides: Total Synthesis, Stereochemical Revision, and SAR Studies toward Identification of Simplified Lead

Total Synthesis and Revision of Stereochemistry of a Natural Benzo[g]isochromene Stereodiad Isolated from Rubia philippinensis

“…By considering ambiguity on the stereochemical pattern, in particular, when dealing with flexible moieties, we wanted to synthesize both diastereomers (3 R ,12 S and 3 R ,12 R ), potentially to resolve any discrepancies in the stereochemical assignments of the targeted molecules and move forward toward lead optimization. In addition, this effort can help us in synthesizing stereoisomers as part of medicinal chemistry toward lead optimization, which is being practiced in our group …”