Comprehensive two-dimensional gas chromatography—quadrupole mass spectrometric analysis of drugs

Song, Shin Miin; Marriott, Philip J.; Wynne, Paul

doi:10.1016/j.chroma.2004.08.087

Cited by 16 publications

(4 citation statements)

References 23 publications

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“…Thus, most GC×GC methods use low‐resolution TOFMS, but some reports of low‐resolution QMS and high‐resolution TOFMS are available. An early example used GC×GC with QMS for drug analysis; a strategy of using a reduced mass scan range was used to increase the scan rate …”

Section: Detection In Gc×gcmentioning

confidence: 99%

Addressing the Challenges to Identification in Gas Chromatography by Increased Resolution and Enhanced Detection Modalities

Marriott

2018

Chemistry An Asian Journal

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In the past 15+ years, gas chromatography (GC) has undergone a renaissance in its implementation on the basis of the "disruptive" technology of comprehensive two-dimensional gas chromatography (GC×GC). With a foundation based upon a two-column GC separation approach, GC×GC significantly alters the classical multidimensional gas chromatography (MDGC) method by employing very fast separation on a second dimension ( D) after a conventional one-dimensional (i.e., single column; 1D) column separation. This allows the experimentalist to apply the advantages of multidimensionality to the total sample rather than to just discrete zones of the 1D separation that characterizes MDGC. This requires a new "language" to describe GC×GC separations, applied to the first dimension ( D) and D, and consideration of the modulation processes that define the transfer of analyte from the D to the D. The present review is based on the FACS Foundation lectureship of the author given at the 17th Asian Chemical Congress of the Federation of Asian Chemical Societies (FACS). The award lecture and this manuscript is based on material deriving largely from research in the area of MDGC and GC×GC separations of the author.

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Section: Detection In Gc×gcmentioning

confidence: 99%

Addressing the Challenges to Identification in Gas Chromatography by Increased Resolution and Enhanced Detection Modalities

Marriott

2018

Chemistry An Asian Journal

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“…The GC × GC-qMS system is also showing its potential to analyze complex samples [211][212][213]. Initially, quadrupole mass spectrometers showed very low data acquisition rates (up to 20 Hz) which made them too slow to use in GC × GC systems [214].…”

Section: Comprehensive Two-dimensional Gas Chromatography (Gc × Gc)mentioning

confidence: 99%

Chromatographic Methods Applied to the Characterization of Bio-Oil from the Pyrolysis of Agro-Industrial Biomasses

Moraes¹,

Tomasini²,

Silva³

et al. 2017

Frontiers in Bioenergy and Biofuels

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Biomass conversion into solid, liquid and gaseous products by pyrolytic technology is one of the most promising alternative to convert the biomass into useful products and energy. The total characterization of the products from the pyrolysis of biomass is one of the great challenges in this field, mainly due to their molecular complexity. Pyrolysis is a process that causes degradation of biomass in a non-oxidative atmosphere, at relatively high temperatures, producing a solid residue rich in carbon and mineral matter, gases and bio-oil. The yield and properties of the products depend on the nature of the biomass and the type of the pyrolysis process (type of reactor, temperature, gas flow, catalyst). Due to the high molecular complexity of bio-oil, many different technical had been developed to their complete characterization. This chapter describes the principles of the techniques and main application of chromatographic methods (GC, LC, GC × GC, LC × LC, Nano-LC) in the analysis of bio-oils derived from thermo-degradation of biomasses. Especial attention is carried out to two-dimensional techniques that represent the state of the art in terms of separation, sensibility, selectivity and velocity of data acquisition for characterization of complex organic mixtures. For proper use of bio-oil in the chemical industry, it is essential the identification and unambiguous determination of its major constituents. Only then, it is possible to propose a recovery route of some of these components for the development of an industry dedicated to a bio-refinery. For this, chromatographic methods, especially GC × GC/MS, are fundamental because they allow analysis with high sensitivity and accuracy in identifying each constituent of the bio-oil.

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“…The simplicity of GC Â GC-qMS with respect to data interpretation and manipulation compared to the more sophisticated GC Â GC-TOFMS has favored a recent increase in its application. Instrumental strategies have been employed to increase qMS scan rates that are necessary for fast GC Â GC separations, including the use of reduced mass scanning ranges (162) and unique truncated libraries to accommodate these reduced ranges (163). Similarly, selected ion monitoring (SIM), whereby the mass spectrometer is set to scan over a very small mass range (typically one mass unit, or a few selected mass ions) has been used with GC Â GC-qMS (160).…”

Section: Plant Metabolomics 343mentioning

confidence: 99%

Analytical Chemistry Considerations in Plant Metabolomics

Ryan¹,

Robards²

2006

Separation & Purification Reviews

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Metabolomics is defined as the comprehensive analysis of all the metabolites of a biological system, although there is considerable confusion in terminology. The task of metabolomics is not attainable with the current state of analytical science, and various approaches are used to accommodate this limitation and the associated complexity of the metabolome. Major advances and a totally new approach to analysis will be essential. Meanwhile, a number of techniques, namely, metabolite profiling, metabolite fingerprinting and target analysis are combined to make this task possible. There is an implicit assumption in these approaches that the data are complementary and that the metabolome can be assessed as a summation of individual data. The integrity of metabolomics data depends on state-of-the-art sample handling and measurement techniques. These ideas are developed in this review.

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Comprehensive two-dimensional gas chromatography—quadrupole mass spectrometric analysis of drugs

Cited by 16 publications

References 23 publications

Addressing the Challenges to Identification in Gas Chromatography by Increased Resolution and Enhanced Detection Modalities

Addressing the Challenges to Identification in Gas Chromatography by Increased Resolution and Enhanced Detection Modalities

Chromatographic Methods Applied to the Characterization of Bio-Oil from the Pyrolysis of Agro-Industrial Biomasses

Analytical Chemistry Considerations in Plant Metabolomics

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