Compulsivity and Obsessionality in Opioid Addiction

Friedman, Irit; Dar, Reuven; Shilony, Etay

doi:10.1097/00005053-200003000-00005

Cited by 35 publications

(20 citation statements)

References 27 publications

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“…Surprisingly, however, they found inflated responsibility in pathological gamblers comparable to obsessive-compulsive patients. By comparison, Friedman, Dar, and Shilony (2000) found that opioid addicts showed an inordinate number of OCD symptoms. Another implication is that impulsiveness is a common core of these disorders, perhaps counteracted in OCD by sensitivity to danger (or responsibility).…”

Section: Introductionmentioning

confidence: 96%

Responsibility and impulsivity and their interaction in relation to obsessive–compulsive symptoms

Smári

Bouranel

Eiðsdóttir

2008

Journal of Behavior Therapy and Experimental Psychiatry

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Section: Introductionmentioning

confidence: 96%

Responsibility and impulsivity and their interaction in relation to obsessive–compulsive symptoms

Smári

Bouranel

Eiðsdóttir

2008

Journal of Behavior Therapy and Experimental Psychiatry

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“…(5) Furthermore, the level of compulsivity and obsessiveness in opioid-dependent patients has been estimated to exceed 12%, a rate which is over 4 times higher than the rate of OCD in the general population [14].…”

Section: Introductionmentioning

confidence: 99%

Do Obsessive-Compulsive Patients and Abstinent Heroin Addicts Share a Common Psychophysiological Mechanism?

et al. 2003

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Background/Aim: Working memory (WM) and attentional deficits have been implicated in the pathophysiology of both obsessive-compulsive disorder (OCD) and opioid addiction. The P300 component of event-related potentials (ERPs) is considered as an index of on-line updating of WM and/or attentional operations involved in this function. The present study aimed at comparing the P300 elicited during a WM test in patients with prolonged heroin abstinence, those with OCD and healthy controls, in order to demonstrate possibly common underlying psychophysiological mechanisms. Methods: The P300 component was evaluated during the anticipatory period of a WM test in 20 patients characterized by a past history of opioid dependence (6 months abstinence), in 18 OCD patients, and 20 healthy subjects matched for age, sex and educational level. Results: The two patient groups showed a considerable reduction of the P300 amplitudes, located at the right frontal area as compared with healthy controls. The abstinent heroin addicts exhibited a significantly lower P300 amplitude at central frontal areas and a significantly higher P300 amplitude at the left occipital region relative to the other two groups. Furthermore, the abstinent group showed a notable delay of P300 latency relative to controls and OCD patients at the right occipital region. Moreover, the OCD patients manifested a significant prolongation of P300 located at the central prefrontal area, relative to addicts and healthy controls. Conclusions: These findings point to considerable WM and/or attentional deficits in the long-term abstinent syndrome of heroin misuse and OCD associated with distributed and prefrontal cortical circuits, respectively. Furthermore, the present findings suggest that both OCD and long-term abstinent heroin addicts may share a common impairment of WM and/or attention involving or affecting the right prefrontal areas.

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“…Ya pı lan ça lış ma lar da OKB has ta ların da psi ko ak tif mad de kul la nım oran la rı %10-12 bu lun muş tur. 17,18 Ob se sif kom pul sif bo zuk lu ğun ilaç te da vi sin de bü yük ge liş me ler ol ma sı na kar şın, ge nel lik le kro nik gi diş ve önem li oran da ki te da vi ba şa rı sız lı ğı göz önü ne alın dı ğın da, hastaların alter na tif bir te da vi ara yı şı için de ol ma la rı bek le nebi lir.…”

Section: Tar Tiş Maunclassified

Treatment Refractory OCD Which Entered Remission After Heroin Use: Case Report

Kalenderoğlu¹,

Selek²,

Yumru³

et al. 2011

Turkiye Klinikleri J Med Sci

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bsesif kompulsif bozukluğun (OKB) kronik gidişi ve önemli oranda tedavi başarısızlığı göz önüne alındığında, toplumsal ve bireysel anlamda ciddi bir ruhsal yük haline gelmektedir. 1 Serotonin geri alım inhibitörleri (SGİ), OKB'li hastalarda birinci seçe-nek ilaçlar olarak kullanılmaktadır.2 Ayrıca OKB hastaları %30-50 oranın-da SGİ'lere belirgin direnç göstermekte, %50-70 oranında ise kısmi cevap alınmaktadır.3 Tedaviye cevap vermeyen hastalarda klomipramin, venlafaksin veya mirtazapine geçilmesi ya da SGİ'ne başka grup ilaçların eklenmesi (lityum, buspiron, yeni antipsikotikler, glutamat antagonistleri) gibi tedavi yaklaşımları önerilmektedir. Tedaviye Dirençli OKB Ö ÖZ ZE ET T Opi o id sis te mi ob se sif kom pul sif bo zuk luğun (OKB) pa to fiz yo lo ji sin de rol ala bi lir. Opi o id siste mi nin ank si ye te bo zuk luk la rı ile mad de kul la nım bo zuk luk la rı ara sın da ki iliş ki tam ola rak bi linme mek le bir lik te, opi o id ba ğım lı la rın da OKB ge nel po pu las yo na gö re dört kat da ha faz la bu lun muş tur. Ek ola rak ba zı ol gu su num la rın da ve açık uç lu ça lış ma lar da, sen te tik opi o id olan trama dol ün ve mor fi nin OKB be lir ti le rin de azal ma ya se bep ol du ğu bil di ril miş tir. Ya pı lan li te ra tür tara ma sın da [(Pub Med, Mesh Pub med, Ovid, Der went In no va ti on In dex (ISI Web of Know led ge), Psi ki yat ri Di zi ni vs.] ero in kul la nı mı nın OKB be lir ti le ri ni dü zelt ti ği ne yö ne lik bir ça lış ma ya rastlan ma mış tır. Bu ya zı mız da diy a be ti ve OKB 'u olan ve muh te me len yan lış ina nış ge re ği kan şeke rini re gü le et mek için ero i ne baş la yan, ero in kul la nı mı son ra sın da OKB be lir ti le rin de azal ma, an cak ero in kul lan ma mik ta rın da art ma olan has ta su nul muş tur.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Di a be tes mel li tus, tip 2; ob se sif-kom pul sif bo zuk luk; opi o id pep tid le ri A AB BS S T TR RA AC CT T The opi o id system may ha ve a ro le in pat ho ge ne sis of ob ses si ve com pul si ve di sor der (OCD). The as so ci a ti on bet we en opi o id system, an xi ety di sor ders and drug ad dic ti on is not comple tely un ders to od, ho we ver OCD is four ti mes mo re fre qu ent in opi o id ad dicts com pa red to nor mal po pu la ti on. Furt her mo re, pre vi o us ca se re ports and unb lin ded stu di es ha ve re por ted that tra ma dol (a synthe tic opi o id) and morp hi ne re du ced the symptoms of OCD. There are not studies in the literature that sho wed im pro ve ment of OCD symptoms with he ro in use. [Pub Med, Mesh Pub med, Ovid, Der went In no va ti on In dex (ISI Web of Know led ge), Psychi atry in dex etc.]. We he re in re port a pa ti ent with OCD who star ted to use he ro in for re gu la ti on of his blo od glu co se le vels as a con sequ en ce of a mis be li ef. Af ter using he ro in, OCD symptoms im pro ved but he ro in ad dic ti on de ve loped.K Ke ey y W Wo or rd ds s: : Di a be tes mel li tus, type 2; ob ses si ve-com pul si ve di sor der; opi o id pep ti des T Tu ur rk ki iy ye ...

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Compulsivity and Obsessionality in Opioid Addiction

Cited by 35 publications

References 27 publications

Responsibility and impulsivity and their interaction in relation to obsessive–compulsive symptoms

Responsibility and impulsivity and their interaction in relation to obsessive–compulsive symptoms

Do Obsessive-Compulsive Patients and Abstinent Heroin Addicts Share a Common Psychophysiological Mechanism?

Treatment Refractory OCD Which Entered Remission After Heroin Use: Case Report

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