Computational biology in topical bioactive peptide discovery for cosmeceutical application: a concise review

Li, Xuhui; Su, Weixin; Wang, Feifei; Li, Ké; Zhu, Jun Gao; Zhu, Siyu; Kang, Seongkeun; He, Congfen; Li, Junxiang; Lin, Xiuping

doi:10.53388/bmec2023014

“…Recent advancements have also highlighted the potential role of artificial intelligence in expanding research in this area. 118 , 119 …”

Section: Summary and Perspectivementioning

confidence: 99%

“…This complexity requires more methodologically rigorous and comprehensive research to determine whether antioxidants should be used as stand‐alone treatments or as part of a broader, synergistic therapeutic approach. Recent advancements have also highlighted the potential role of artificial intelligence in expanding research in this area 118,119 …”

Section: Summary and Perspectivementioning

confidence: 99%

Role of oxidative stress in the concurrent development of osteoporosis and tendinopathy: Emerging challenges and prospects for treatment modalities

Xia,

Fang,

Qian

et al. 2024

J Cellular Molecular Medi

2

0

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Both osteoporosis and tendinopathy are widely prevalent disorders, encountered in diverse medical contexts. Whilst each condition has distinct pathophysiological characteristics, they share several risk factors and underlying causes. Notably, oxidative stress emerges as a crucial intersecting factor, playing a pivotal role in the onset and progression of both diseases. This imbalance arises from a dysregulation in generating and neutralising reactive oxygen species (ROS), leading to an abnormal oxidative environment. Elevated levels of ROS can induce multiple cellular disruptions, such as cytotoxicity, apoptosis activation and reduced cell function, contributing to tissue deterioration and weakening the structural integrity of bones and tendons. Antioxidants are substances that can prevent or slow down the oxidation process, including Vitamin C, melatonin, resveratrol, anthocyanins and so on, demonstrating potential in treating these overlapping disorders. This comprehensive review aims to elucidate the complex role of oxidative stress within the interlinked pathways of these comorbid conditions. By integrating contemporary research and empirical findings, our objective is to outline new conceptual models and innovative treatment strategies for effectively managing these prevalent diseases. This review underscores the importance of further in‐depth research to validate the efficacy of antioxidants and traditional Chinese medicine in treatment plans, as well as to explore targeted interventions focused on oxidative stress as promising areas for future medical advancements.

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“…Bioinspired by fluorescent-labeled antibodies, here, we designed as a universal detection platform based on the peptide-conjugated probes (PCPs, name as T P -TPE-T O ) by integrating protein recognition units and cell membrane penetration units, optimizing signal units, and particularly introducing organelle targeting units. [8] The universal detection platform can achieve protein analysis in different organelles through simple transformation of recognition and targeting units. In detail, as shown in Scheme 1, this platform consisted of three parts: a) a tetraphenylethylene (TPE) derivative molecule with two different functional end groups as a core unit.…”

Section: Introductionmentioning

confidence: 99%

A Universal and Programmable Platform based on Fluorescent Peptide‐Conjugated Probes for Detection of Proteins in Organelles of Living Cells

Wu,

Hu,

Duan

et al. 2024

Angewandte Chemie

1

0

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Realizing protein analysis in organelles of living cells is of great significance for developing diagnostic and therapeutic methods of diseases. Fluorescent‐labeled antibodies with well imaging performance and high affinity are classical biochemical tools for protein analysis, while due to the inability to effectively enter into cells, not to mention organelles and the uncontrollable reaction sites that might cause antibodies inactivation when chemically modification, they are hard to apply to living cells. Inspired by the structure of fluorescent‐labeled antibodies, we designed as a universal detection platform that was based on the peptide‐conjugated probes (PCPs) and consisted of three parts: a) a rotor type fluorescent molecular scaffold for conjugation and signal output; b) the cell penetration protein recognition unit; c) the subcellular organelle targeting unit. In living cells, PCPs could firstly localize at organelles and then proceed protein specific recognition, thus jointly leading to the restriction of twisted intramolecular charge transfer and activation of fluorescence signal. As a proof‐of‐concept, six different proteins in three typical intracellular organelles could be detected by our platform through simply replacing the recognition sequence of proteins and matching organelle targeting units. The position and intensity of fluorescence signals demonstrated specificity of PCPs and universality of the platform.

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A Universal and Programmable Platform based on Fluorescent Peptide‐Conjugated Probes for Detection of Proteins in Organelles of Living Cells

Wu,

Hu,

Duan

et al. 2024

Angew Chem Int Ed

3

0

View full text Add to dashboard Cite

Realizing protein analysis in organelles of living cells is of great significance for developing diagnostic and therapeutic methods of diseases. Fluorescent‐labeled antibodies with well imaging performance and high affinity are classical biochemical tools for protein analysis, while due to the inability to effectively enter into cells, not to mention organelles and the uncontrollable reaction sites that might cause antibodies inactivation when chemically modification, they are hard to apply to living cells. Inspired by the structure of fluorescent‐labeled antibodies, we designed as a universal detection platform that was based on the peptide‐conjugated probes (PCPs) and consisted of three parts: a) a rotor type fluorescent molecular scaffold for conjugation and signal output; b) the cell penetration protein recognition unit; c) the subcellular organelle targeting unit. In living cells, PCPs could firstly localize at organelles and then proceed protein specific recognition, thus jointly leading to the restriction of twisted intramolecular charge transfer and activation of fluorescence signal. As a proof‐of‐concept, six different proteins in three typical intracellular organelles could be detected by our platform through simply replacing the recognition sequence of proteins and matching organelle targeting units. The position and intensity of fluorescence signals demonstrated specificity of PCPs and universality of the platform.

show abstract

Computational biology in topical bioactive peptide discovery for cosmeceutical application: a concise review

Cited by 4 publications

References 0 publications

Role of oxidative stress in the concurrent development of osteoporosis and tendinopathy: Emerging challenges and prospects for treatment modalities

Role of oxidative stress in the concurrent development of osteoporosis and tendinopathy: Emerging challenges and prospects for treatment modalities

A Universal and Programmable Platform based on Fluorescent Peptide‐Conjugated Probes for Detection of Proteins in Organelles of Living Cells

A Universal and Programmable Platform based on Fluorescent Peptide‐Conjugated Probes for Detection of Proteins in Organelles of Living Cells

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