Computational Dynamic Modeling of Thin Film Evaporators and Condensers

Abstract

The steady and dynamic behavior of thin film evaporators and condensers are simulated with a general thin film heat exchanger model. The dynamics of the gravity-controlled falling laminar film on horizontal and vertical tubes are studied in detail. For a first approximation or for a slow transient a single-lumped model can be used. For a refined simulation or for a severe transient a grouped model is proposed. The grouped model preserves the important feature of delay-time and wave-distortion of a transient, which was observed in a separate precise analysis [9]. The thin film heat exchanger models are used in the dynamic simulation computer programs ODSP3 and OSCAR which were established for OTEC systems. Typical results are presented to demonstrate the capability of the model.

Technical Considerations for Use of Oligonucleotide Solution API

“…The process can be scaled by using equipment with increased evaporation area, thus maintaining practicable processing times as the process is scaled up. TFE is amenable to process modeling [ 25 , 27 ] and there is the potential for continuous manufacture. A downside of TFE is that salts cannot be removed, and it is therefore likely to be introduced as an additional API process step after UF/DF.…”

“…Thin film evaporation (TFE), or wiped film evaporation [24][25][26][27][28], is a distillation process where the solution flows through cylindrical equipment and is wiped around the internal wall by blades or rollers to form a thin film. A jacket is used to heat the walls of the equipment and the process takes place at reduced pressure, causing water to evaporate from the oligonucleotide solution as it travels through the evaporator.…”