Computational exploration of polymorphisms in 5-Hydoxytryptamine 5-HT1A and 5-HT2A receptors associated with psychiatric disease

The function and structural influence of selective relaxed constraint at functional intracellular loop3 of 5-HT1A serotonin-1 receptor family

“…Even the change in physiochemical property does not seem to affect the functional significance as shown by the SIFT score. Our previous study has extensively analyzed the natural variations within human population for functional deleteriousness in serotonin receptor family (Dass and Sudandiradoss, 2012). In this study the result suggests that the variation at the ICL 3 regions across the species was well tolerated.…”