Computational fluid dynamic modeling of the effect of dupilumab in the management of anosmia secondary to chronic rhinosinusitis with nasal polyps (CRSwNP)

Lepley, Thomas J; Wu, Zhenxing; Root, Zach; Mountain, Drew; Otto, Bradley A.; Kelly, Kathleen M.; Zhao, Kai

doi:10.1002/alr.23050

Cited by 1 publication

(1 citation statement)

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“…65 CFD has shown that dupilumab may have an anti-inflammatory effect in the olfactory region, which is unique from sinus surgery, permitting more airflow to reach the olfactory neurons. 66 Virtual Surgery Planning CFD modeling presents a unique option for virtual surgery planning. Current literature most predominantly looks at surgeries for nasal airway obstruction in which results are known to be quite variable, but uses could certainly expand beyond that.…”

Section: Nasal Aerodynamics and Olfactionmentioning

confidence: 99%

Computational Fluid Dynamics and Its Potential Applications for the ENT Clinician

Root,

Schneller,

Lepley

et al. 2024

Facial Plast Surg

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This article is an examination of computational fluid dynamics in the field of otolaryngology, specifically rhinology. The historical development and subsequent application of computational fluid dynamics continues to enhance our understanding of various sinonasal conditions and surgical planning in the field today. This article aims to provide a description of computational fluid dynamics, the methods for its application, and the clinical relevance of its results. Consideration of recent research and data in computational fluid dynamics demonstrates its use in nonhistological disease pathology exploration, accompanied by a large potential for surgical guidance applications. Additionally, this article defines in lay terms the variables analyzed in the computational fluid dynamic process, including velocity, wall shear stress, area, resistance, and heat flux.

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Section: Nasal Aerodynamics and Olfactionmentioning

confidence: 99%