2021
DOI: 10.1186/s43094-021-00373-6
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Computational insight to design new potential hepatitis C virus NS5B polymerase inhibitors with drug-likeness and pharmacokinetic ADMET parameters predictions

Abstract: Background Hepatitis C virus (HCV) is considered a worldwide health problem since it affects over 3% of the population and causes 300,000 fatalities per year. Chronic infection causes high morbidity and mortality in patients, leading to liver cirrhosis, hepatocellular carcinoma, fibrosis, liver cancer, and other HCV-related illnesses. Finding novel and better HCV treatments is a top international health goal right now. As a result, the pressing need for new HCV antiviral drugs has fueled resear… Show more

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Cited by 7 publications
(2 citation statements)
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“…Novel cinnamamides 3b-i were not mutagenic (Ames-negative), not toxic to the liver, and did not become hERGI/II inhibitors as shown in Table 4. All of the synthesized compounds had high values (log (mol/kg/day) > 0.477), where the highest MRTD value was found in cinnamamide 3d [39]. The highest acute oral toxicity value in rats is found in compound 3e, with an LD50 value of 2.848 mol/kg.…”
Section: Physicochemical Pharmacokinetics and Toxicity Studiesmentioning
confidence: 96%
“…Novel cinnamamides 3b-i were not mutagenic (Ames-negative), not toxic to the liver, and did not become hERGI/II inhibitors as shown in Table 4. All of the synthesized compounds had high values (log (mol/kg/day) > 0.477), where the highest MRTD value was found in cinnamamide 3d [39]. The highest acute oral toxicity value in rats is found in compound 3e, with an LD50 value of 2.848 mol/kg.…”
Section: Physicochemical Pharmacokinetics and Toxicity Studiesmentioning
confidence: 96%
“…Hepatitis C is a communicable illness that gradually harms the liver, ultimately leading to cirrhosis and death. It is a severe public health issue globally, affecting up to 3% of the population and resulting in over 300,000 deaths annually [ 68 , 69 , 70 ]. Its slow progression and challenging detection make it a concealed pandemic, and the majority of infections result in long-lasting conditions that can persist for years.…”
Section: Hepatitis C Virus Nonstructural Protein 5b (Ns5b)mentioning
confidence: 99%