Computational insights into the antioxidant and antidiabetic mechanisms of cannabidiol: An in vitro and in silico study

The thermodynamic characteristics, antioxidant potential, and photoprotective benefits of full‐spectrum cannabidiol (FS‐CBD) against UVB‐induced cellular death were examined in this study. In silico analysis of CBD showed antioxidant capacity via proton donation and UV absorption at 209.09, 254.73, and 276.95 nm, according to the HAT and SPLET methodologies. FS‐CBD protected against UVB‐induced bacterial death for 30 min. FS‐CBD protected against UVB‐induced cell death by 42% (1.5 μg/mL) and 35% (3.5 μg/mL) in an in vitro keratinocyte cell model. An in vivo acute irradiated CD‐1et/et mouse model (UVB‐irradiated for 5 min) presented very low photoprotection when FS‐CBD was applied cutaneously, as determined by histological analyses. In vivo skin samples showed that FS‐CBD regulated inflammatory responses by inhibiting the inflammatory markers TGF‐β1 and NLRP3. The docking analysis showed that the CBD molecule had a high affinity for TGF‐β1 and NLRP3, indicating that protection against inflammation might be mediated by blocking these proinflammatory molecules. This result was corroborated by the docking interactions between CBD and TGF‐β1 and NLRP3, which resulted in a high affinity and inhibition of both proteins The present work suggested a FS‐CBD moderate photoprotective agent against UVB light‐induced skin damage and that this effect is partially mediated by its anti‐inflammatory activity.

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Computational insights into the antioxidant and antidiabetic mechanisms of cannabidiol: An in vitro and in silico study

Cited by 3 publications

References 47 publications

A comprehensive molecular analysis of cannabidiol: From solid state to antioxidant potential

A comprehensive molecular analysis of cannabidiol: From solid state to antioxidant potential

Exploring the inhibitory action of betulinic acid on key digestive enzymes linked to diabetes via in vitro and computational models: approaches to anti-diabetic mechanisms

Full‐spectrum cannabidiol reduces UVB damage through the inhibition of TGF‐β1 and the NLRP3 inflammasome

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