Computational intelligence spectrophotometric scenarios for screening and quantification of single-dose triple therapy banned by the World Anti-Doping Agency in some sports

Lotfy, Hayam M.; El-Hanboushy, Sara; Fayez, Yasmin M.; Abdelkawy, Mohamed; Marzouk, Hoda M.

doi:10.1016/j.microc.2023.109581

Microchemical Journal

2024

DOI: 10.1016/j.microc.2023.109581

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Computational intelligence spectrophotometric scenarios for screening and quantification of single-dose triple therapy banned by the World Anti-Doping Agency in some sports

Hayam M. Lotfy,

Sara El-Hanboushy,

Yasmin M. Fayez

et al.

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Cited by 6 publications

References 34 publications

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A validated LC-MS/MS method for determination of Molnupiravir and Favipiravir in human plasma; Assessment of the remarkable potential synergistic effect against SARS-CoV-2 Infection: Application to a pharmacokinetic study in healthy Egyptian volunteers

Marzouk,

Gouda,

Rezk

et al. 2024

Microchemical Journal

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A validated LC-MS/MS method for determination of Molnupiravir and Favipiravir in human plasma; Assessment of the remarkable potential synergistic effect against SARS-CoV-2 Infection: Application to a pharmacokinetic study in healthy Egyptian volunteers

Marzouk,

Gouda,

Rezk

et al. 2024

Microchemical Journal

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A multipurpose eco-friendly separation-based approach for appraisal of a single-pill triple-action cramp relief combination; impurity separation, dissolution study and greenness/whiteness assessment

Ibrahim,

Saad,

Hegazy

et al. 2024

Microchemical Journal

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Ecofriendly micellar mediated spectrofluorimetric method for ultrasensitive quantification of the antiparkinsonian drug safinamide in pharmaceutical formulation and spiked human plasma

Ibrahim,

Marzouk,

Hegazy

et al. 2024

Sci Rep

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A novel, highly sensitive and eco-friendly micellar-mediated spectrofluorimetric method was developed and validated for the determination of the novel antiparkinsonian drug safinamide mesylate in the presence of its related precursor impurity, 4-hydroxybenzaldehyde. The proposed approach relies on increasing the inherent fluorescence emission at 296 nm of safinamide, by forming hydrogen bonds between the mentioned drug and sodium dodecyl sulfate in the micellar system using 0.1 N HCl as a solvent, following excitation at 226 nm. A thorough investigation was conducted into the experimental factors affecting spectrofluorimetric behavior of the studied drug. A linearity plot of safinamide over the concentration range of 10.0–1000.0 ng/mL against the relative fluorescence intensities was established. The proposed method demonstrated excellent sensitivity down to the nano-gram level with detection and quantitation limits of 1.91 and 5.79 ng/mL, respectively. The studied drug was effectively determined in Parkimedine® Tablets. Furthermore, the proposed method allows for ultrasensitive quantification of safinamide in spiked human plasma, with satisfactory percentage recovery (98.97–102.28%). Additionally, the greenness assessment using the advanced green certificate classification approach, the complementary green analytical procedure index (Complex-GAPI), and the analytical GREEness metric approach (AGREE), along with the practicality check using the Blue Applicability Grade Index in addition to the all-inclusive overall whiteness evaluation using the RGB-12 model were carried out. The outcomes demonstrated the effectiveness and whiteness of the proposed technique. Clearly, the suggested approach has the advantages of being simple, requiring no pretreatment steps, and relying solely on direct measuring procedures.

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Computational intelligence spectrophotometric scenarios for screening and quantification of single-dose triple therapy banned by the World Anti-Doping Agency in some sports

Cited by 6 publications

References 34 publications

A validated LC-MS/MS method for determination of Molnupiravir and Favipiravir in human plasma; Assessment of the remarkable potential synergistic effect against SARS-CoV-2 Infection: Application to a pharmacokinetic study in healthy Egyptian volunteers

A validated LC-MS/MS method for determination of Molnupiravir and Favipiravir in human plasma; Assessment of the remarkable potential synergistic effect against SARS-CoV-2 Infection: Application to a pharmacokinetic study in healthy Egyptian volunteers

A multipurpose eco-friendly separation-based approach for appraisal of a single-pill triple-action cramp relief combination; impurity separation, dissolution study and greenness/whiteness assessment

Ecofriendly micellar mediated spectrofluorimetric method for ultrasensitive quantification of the antiparkinsonian drug safinamide in pharmaceutical formulation and spiked human plasma

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